Skip to main content

3,485 Result(s)

within English Remove this filter Medicine & Public Health Remove this filter Internal Medicine Remove this filter Medicine/Public Health, general Remove this filter Oncology Remove this filter **u-**u Zhang Remove this filter

previous disabled Page of 175
and

  1. No Access

    Article

    Inhibition of the growth of WI-38 fibroblasts by benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone: evidence that cleavage of p53 by a calpain-like protease is necessary for G1 to S-phase transition

    The effect of a calpain-selective cell permeant inhibitor, benzyloxycarbonyl Leu-Leu-Tyr diazomethylketone (ZLLY-CHN2), on the serum-stimulated growth of WI-38 human fibroblasts has been investigated. Only cell p...

    Wenli Zhang, Qin Lu, Zi-Jian **e, Ronald L Mellgren in Oncogene (1997)

  2. No Access

    Article

    Mob-1, a Ras target gene, is overexpressed in colorectal cancer

    Mutations in the ras oncogenes have been linked to many different cancers. In contrast to the extensive body of knowledge related to the genetics of ras activation, relatively little is known of the transcript...

    Rong Zhang, Hong Zhang, Weimin Zhu, Arthur B Pardee, RJ Coffey Jr, Peng Liang in Oncogene (1997)

  3. No Access

    Article

    The 96 kDa protein kinase activated by oncogenic Ras in Xenopus egg extracts is also activated by constitutively active Mek: activation requires serine/threonine phosphorylation

    In the Xenopus egg and oocyte system, oncogenic Ras protein can induce cell cycle arrest. The effect of oncogenic Ras on the cell cycle seems to be mediated by the Raf – Mek – Erk pathway of Ras signal transdu...

    Bin-Tao Pan, Yong Zhang, Barbara Brott, Dong-Hua Chen in Oncogene (1997)

  4. No Access

    Article

    Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

    The recently cloned gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T) is involved in DNA damage response at different cell cycle checkpoints and also appears to have a wider role in ...

    Dianne Watters, Kum Kum Khanna, Heather Beamish, Geoffrey Birrell, Kevin Spring… in Oncogene (1997)

  5. No Access

    Article

    Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells

    We have analysed the relationship of the products of two genes, neu and BRCA1, known to be important in human breast cancer. Highly specific antibodies that recognized both the rodent and human form of the BRCA1 ...

    Hong-Tao Zhang, **n Zhang, Hui-Zhen Zhao, Yuri Ka**o, Barbara L Weber… in Oncogene (1997)

  6. No Access

    Article

    Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells

    A novel polymerase chain reaction (PCR)-based method was used to identify candidate genes whose expression is altered in cancer cells by ionizing radiation. Transcriptional induction of randomly selected genes...

    Elizabeth K Balcer-Kubiczek, Stephen J Meltzer, Lin-Huang Han, **ao-Feng Zhang… in Oncogene (1997)

  7. No Access

    Article

    PLC-γ activation is required for PDGF-βR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells

    To investigate the molecular mechanisms mediating hematopoietic cell differentiation and mitogenesis by activation of the platelet-derived growth factor β receptor (PDGF-βR), the wild type PDGF-βR (PDGF-βRWT) ...

    Maurizio Alimandi, Mohammad A Heidaran, J Silvio Gutkind, Jiachang Zhang… in Oncogene (1997)

  8. No Access

    Article

    The cDNA cloning of the transcripts of human PEBP2αA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia

    PEBP2/CBF is a heterodimeric transcription factor composed of α and β subunits. There are at least three closely related genes, PEBP2αA/Cbfa1, AML1/PEBP2αB/Cbfa2 and PEBP2αC/Cbfa3, encoding the α subunit and one ...

    Yu-Wen Zhang, Suk-Chul Bae, Ei-ichi Takahashi, Yoshiaki Ito in Oncogene (1997)

  9. No Access

    Article

    Partial characterization of the woodchuck tumor suppressor, p53, and its interaction with woodchuck hepatitis virus X antigen in hepatocarcinogenesis

    Full length cDNAs for p53 were made by reverse transcription-polymerase chain reaction of total RNA from two normal woodchuck livers. Two randomly chosen clones from each liver were sequenced and shown to be i...

    Mark A Feitelson, Perungavur N Ranganathan, Marcia M Clayton, Shu Min Zhang in Oncogene (1997)

  10. No Access

    Article

    New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26

    Loss of heterozygosity on chromosome 10 is considered to be associated with the progression of glioblastomas. Two closely related regions have recently been proposed to contain the glioblastoma suppressor locu...

    Daniel Maier, Domenico Comparone, Elisabeth Taylor, Zuwen Zhang, Otmar Gratzl… in Oncogene (1997)

  11. No Access

    Article

    ETS-1 induces increased expression of erythroid markers in the pluripotent erythroleukemic cell lines K562 and HEL

    Members of the ETS gene family are known to be expressed in hematopoietic tissues and cell lines, and there is increasing evidence that ETS proteins may play a role in normal hematopoietic cell development. We...

    PA Clausen, M Athanasiou, Z Chen, KJ Dunn, Q Zhang, JA Lautenberger… in Leukemia (1997)

  12. No Access

    Article

    Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

    The farnesyltransferase (FTase) inhibitor FTI-277 is highly effective at blocking oncogenic H-Ras but not K-Ras4B processing and signaling. While inhibition of processing and signaling of oncogenic K-Ras4B is ...

    Edwina C Lerner, Ting-Ting Zhang, David B Knowles, Yimin Qian… in Oncogene (1997)

  13. No Access

    Article

    p53 expression overcomes p21WAF1/CIP1-mediated G1 arrest and induces apoptosis in human cancer cells

    The p21WAF1/CIP1 gene, which encodes a cyclin-dependent kinase inhibitor, may be critical for tumor suppressor gene p53-induced cell cycle arrest. The p53 gene is known to regulate G1 checkpoint, which can either...

    Shunsuke Kagawa, Toshiyoshi Fujiwara, Akio Hizuta, Tatsuji Yasuda… in Oncogene (1997)

  14. No Access

    Article

    MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice

    FGF-1 is expressed in a high proportion of breast tumors. While overexpression of FGF-4 in the MCF-7 breast carcinoma cell line confers the ability to form spontaneously metastasizing tumors in ovariectomized ...

    Lurong Zhang, Samir Kharbanda, Denise Chen, Jamal Bullocks, David L Miller… in Oncogene (1997)

  15. No Access

    Article

    Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation

    ARK (AXL) is the prototype of a distinctive family of receptor tyrosine kinases which contain in their extracellular domains features reminiscent of cell adhesion molecules. ARK is capable of homophilic bindin...

    Paola Bellosta, Qing Zhang, Stephen P Goff, Claudio Basilico in Oncogene (1997)

  16. No Access

    Article

    Characterization of human N8 protein

    We have shown before that the N8 mRNA is expressed at higher levels in lung tumor and lung tumor-derived cell lines than normal lung cells. In this paper, we have characterized the N8 protein, and studied its ...

    Shin-Lin Chen, **an-Kui Zhang, Douglas O Halverson, Mee Kyeong Byeon… in Oncogene (1997)

  17. No Access

    Article

    PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium

    Tamoxifen is currently the most widely used drug for the treatment of breast cancer, but there now exists considerable evidence that tamoxifen can also induce endometrial hyperplasia in pre menopausal women. W...

    Yuan Zhao, Stephen Hague, Sanjiv Manek, Lyna Zhang, Roy Bicknell… in Oncogene (1998)

  18. No Access

    Article

    Breast cancer genome anatomy: correlation of morphological changes in breast carcinomas with expression of the novel gene product Di12

    To determine which genes may be activated or inactivated during breast cancer development, we employed two cloning strategies (subtractive hybridization and differential display) using RNA samples from a human...

    Angelika Burger, Hua Li, **an-Kui Zhang, Malgorzata Pienkowska, Marco Venanzoni… in Oncogene (1998)

  19. No Access

    Article

    Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the develo** neural tube

    The ephrins are a family of ligands that bind to Eph family receptor tyrosine kinases, and have been implicated in axon guidance and other patterning processes during vertebrate development. We describe here t...

    Andrew D Bergemann, Lee Zhang, Ming-Ko Chiang, Riccardo Brambilla… in Oncogene (1998)

  20. No Access

    Article

    Frequent homozygous deletions in the FRA3B region in tumor cell lines still leave the FHIT exons intact

    FRA3B at human chromosomal band 3p14.2 is the most active common fragile site in the human genome. The molecular mechanism of fragility at this region remains unknown but does not involve expansion of a trinuc...

    Liang Wang, John Darling, **-San Zhang, Chi-** Qian, Lynn Hartmann… in Oncogene (1998)

previous disabled Page of 175