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Article
Dual-mode colorimetric electrochemical aptamer sensor based on Au@Pd bimetallic nanoparticles for the detection of Pb(II) in edible mushrooms
Pb(II) can accumulate in the body and gradually cause irreversible harm. In this work, a dual-mode colorimetric biosensor based on an aptamer was developed as an effective method for sensitive sensing of Pb(II...
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Article
Open AccessAn offset calibration scheme for on-chip thermal profiling with differential temperature sensors
This paper introduces an on-chip analog calibration method tailored for differential temperature sensors in thermal monitoring applications. A three-step calibration process is proposed within a two-stage high...
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Article
Open AccessAuthor Correction: Inhibition of lysine acetyltransferase KAT6 in ER+HER2− metastatic breast cancer: a phase 1 trial
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Article
Open AccessLight regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis
Intron retention (IR) is the most common alternative splicing event in Arabidopsis. An increasing number of studies have demonstrated the major role of IR in gene expression regulation. The impacts of IR on plant...
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Article
Fabrication and characterization of biomimetic injectable HA/GT-OSA composites for bone regeneration
To address the issue of limited bone repair efficacy, a novel biomimetic HA/GT-OSA composite was synthesized through crosslinking gelatin (GT) with oxidized sodium alginate (OSA) for encapsulating hydroxyapati...
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Article
Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer
Tumor immunotherapy brings new light and vitality to breast cancer patients, but low response rate and limitations of therapeutic targets become major obstacles to its clinical application. Recent studies have...
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Article
Groundwater suitability assessment for irrigation and drinking purposes by integrating spatial analysis, machine learning, water quality index, and health risk model
An in-depth understanding of nitrate-contaminated surface water and groundwater quality and associated risks is important for groundwater management. Hydrochemical characteristics and driving forces of groundw...
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Article
Open AccessInhibition of lysine acetyltransferase KAT6 in ER+HER2− metastatic breast cancer: a phase 1 trial
Inhibition of histone lysine acetyltransferases (KATs) KAT6A and KAT6B has shown antitumor activity in estrogen receptor-positive (ER+) breast cancer preclinical models. PF-07248144 is a selective catalytic inhib...
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Article
Open AccessMaritime Freight Carbon Emission in the U.S. using AIS data from 2018 to 2022
Global maritime emissions, a 3% contributor to greenhouse gases, anticipate a surge of 90–130% by 2050. Regulatory challenges persist due to international governance gaps. Legislative strides, including the EU...
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Article
Discovery of a T cell proliferation-associated regulator signature correlates with prognosis risk and immunotherapy response in bladder cancer
The efficacy of immunotherapy is heavily influenced by T cell activity. This study aimed to examine how T cell proliferation regulators can predict the prognosis and response to immunotherapy in patients with ...
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Article
Aluminium(I) anion-supported zero-valent palladium complexes
Monovalent group 13 element anions, such as boryl [BR2]− and aluminyl [AlR2]− anions, serve as nucleophiles to form diverse group 13 element-containing molecules. Although transition-metal complexes bearing group...
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Article
Open AccessProbing the activated complex of the F + NH3 reaction via a dipole-bound state
Experimental characterization of the transition state poses a significant challenge due to its fleeting nature. Negative ion photodetachment offers a unique tool for probing transition states and their vicinit...
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Article
Obstructive sleep apnea in relation to beat-to-beat, reading-to-reading, and day-to-day blood pressure variability
We investigated blood pressure (BP) variability as assessed by beat-to-beat, reading-to-reading and day-to-day BP variability indices in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). In 786 ...
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Article
Electrospun HA-SiO2 inorganic fibrous membrane for bone regeneration
In this study, we prepared HA-SiO2 inorganic fibrous membranes loaded with hydroxyapatite by electrospinning. Addition of hydroxyapatite improved the bioactivity of HA-SiO2 fibrous membranes compared with pure si...
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Article
Two-color emissive AIEgens with anti-Kasha property for dual-organelle imaging and phototherapy
Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggreg...
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Article
An efficient surrogate-assisted Taguchi salp swarm algorithm and its application for intrusion detection
The meta-heuristic algorithms require a lot of fitness calculations to get good enough solutions, which constitutes an obstacle to solving computationally complex practical problems. Recently, it has been foun...
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Article
miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39
Exosomes are emerging mediators of cell-cell communication, which are secreted from cells and may be delivered into recipient cells in cell biological processes. Here, we examined microRNA (miRNA) expression i...
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Article
Decisions for power battery closed-loop supply chain: cascade utilization and extended producer responsibility
This study explores the influence of cascade utilization and Extended Producer Responsibility (EPR) regulation on the closed-loop supply chain of power batteries. Three pricing decision models are established ...
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Article
Near-infrared fluorescence-assisted superficial inguinal lymph-node excision for low-risk penile cancer
Identification of superficial inguinal lymph nodes during low-risk penile cancer surgery using near-infrared (NIR) fluorescence to improve the accuracy of lymph-node dissection and reduce the incidence of miss...
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Article
Accumulation and composition characteristics of organic phosphorus in sediments from the Yangtze River–connected lakes, China
Lying in the flood basin of the Yangtze River, Lake Poyang (PY) and Lake Dongting (DT) have suffered from strong hydrological alternations due to the operation of The Three Gorges Dam. Yet, it is still unclear...
