42 Result(s)

Article

Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat

Embryonic stem cells (ESCs) exhibit unique attributes of boundless self-renewal and pluripotency, making them invaluable for fundamental investigations and clinical endeavors. Previous examinations of microgra...

Ying Ye, Wenyan **e, Zhaoru Ma, Xuepeng Wang, Yi Wen, Xuemei Li… in Cell Death Discovery (2024)

Article

Fatty acid metabolism of immune cells: a new target of tumour immunotherapy

Metabolic competition between tumour cells and immune cells for limited nutrients is an important feature of the tumour microenvironment (TME) and is closely related to the outcome of tumour immune escape. A l...

Sheng Zhang, Kebing Lv, Zhen Liu, Ran Zhao, Fei Li in Cell Death Discovery (2024)

Article

Mettl1-mediated internal m⁷G methylation of Sptbn2 mRNA elicits neurogenesis and anti-alzheimer’s disease

N⁷-methylguanosine (m⁷G) is one of the most conserved modifications in nucleosides impacting mRNA export, splicing, and translation. However, the precise function and molecular mechanism of internal mRNA m⁷G meth...

Qingfeng Li, Hui Liu, Lishi Li, Haomin Guo, Zhihao **e, Xuejian Kong… in Cell & Bioscience (2023)

Article

Hepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function

Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it is important for chronic liver injury. However, the roles of Sox9⁺ hepatocytes in response...

Dan Qin, Rui Wang, **wei Ji, Duo Wang, Yuanyuan Lu, Shiyao Cao… in Cell & Bioscience (2023)

Article

Odontoblasts release exosomes to regulate the odontoblastic differentiation of dental pulp stem cells

Dental pulp stem cells (DPSCs) play a crucial role in dentin-pulp complex regeneration. Further understanding of the mechanism by which DPSCs remain in a quiescent state could contribute to improvements in the...

**nghong Luo, Weiqing Feng, Shijiang Huang, Shenghong Miao… in Stem Cell Research & Therapy (2023)

Article

Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporters

Naturally occurring fluorescent proteins (FPs) are the most widely used tools for tracking cellular proteins and sensing cellular events. Here, we chemically evolved the self-labeling SNAP-tag into a palette o...

Dasheng Zhang, Zhengda Chen, Zengmin Du, Bingkun Bao, Ni Su, **anjun Chen… in Cell Discovery (2023)

Article

Targeting tumor-associated macrophages in hepatocellular carcinoma: biology, strategy, and immunotherapy

Hepatocellular carcinoma (HCC), one of the most malignant tumors, is characterized by its stubborn immunosuppressive microenvironment. As one of the main members of the tumor microenvironment (TME) of HCC, tum...

Hongyu Zheng, Xueqiang Peng, Shuo Yang, **nyu Li, Mingyao Huang… in Cell Death Discovery (2023)

Article

FTO stabilizes MIS12 and counteracts senescence

Sheng Zhang, Zeming Wu, Yue Shi, Si Wang, Jie Ren, Zihui Yu… in Protein & Cell (2022)

Article

Systematic comparation of the biological and transcriptomic landscapes of human amniotic mesenchymal stem cells under serum-containing and serum-free conditions

Human amniotic mesenchymal stem cells (hAMSCs) are splendid cell sources for clinical application in the administration of numerous refractory and relapse diseases. Despite the preferable prospect of serum-fre...

Yunyan Sun, Ti-er Wang, Qianwen Hu, Wenxia Zhang, Yun Zeng… in Stem Cell Research & Therapy (2022)

Article

Correction to: DC-SIGN–LEF1/TCF1–miR-185 feedback loop promotes colorectal cancer invasion and metastasis

A Correction to this paper has been published: https://doi.org/10.1038/s41418-021-00736-9

Menglang Yuan, **nsheng Zhang, **gbo Zhang, Keyong Wang… in Cell Death & Differentiation (2022)

Article

MicroRNA-206 down-regulated human umbilical cord mesenchymal stem cells alleviate cognitive decline in D-galactose-induced aging mice

Non-pathological cognitive decline is a neurodegenerative condition associated with brain aging owing to epigenetic changes, telomere shortening, stem cells exhaustion, or altered differentiation. Human umbili...

Yuying Zhang, Weiyue Deng, Wei Wang, Aishi Song, Omar Mukama… in Cell Death Discovery (2022)

Article

BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1

Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role ...

Yufeng Zhang, Min Yang, Sheng Zhang, Zhiqiang Yang, Yufan Zhu, Yi Wang… in Cell & Bioscience (2022)

Article

Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle

Alopecia areata (AA) is a common autoimmune hair loss disease with increasing incidence. Corticosteroids are the most widely used for hair loss treatment; however, long-term usage of hormonal drugs is associat...

Weiyue Deng, Yuying Zhang, Wei Wang, Aishi Song… in Stem Cell Research & Therapy (2021)

Article

USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription

Radioresistance is regarded as the main barrier to effective radiotherapy in lung cancer. However, the underlying mechanisms of radioresistance remain elusive. Here, we show that lysine-specific demethylase 4C...

**aohua Jie, William Pat Fong, Rui Zhou, Ye Zhao… in Cell Death & Differentiation (2021)

Article

Bone marrow-derived mesenchymal stem/stromal cells in patients with acute myeloid leukemia reveal transcriptome alterations and deficiency in cellular vitality

State-of-the-art advances have indicated the pivotal characteristics of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) in hematopoietic microenvironment as well as coordinate contribution to hema...

Leisheng Zhang, Ying Chi, Yimeng Wei, Wenxia Zhang… in Stem Cell Research & Therapy (2021)