43 Result(s)

Article

YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3

Disseminated intravascular coagulation (DIC) is considered to be the most common and lethal complication of sepsis. NLR-family pyrin domain-containing-3 (NLRP3) inflammasome plays an important role in host def...

Chang Liu, Caihong Fan, Jia Liu, Shiqi Zhang, Huixin Tang… in Cell Death & Disease (2024)

Article

Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis

Radioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found that FBXO22 was aberrantly highly expressed in lung cancer and...

Yunshang Chen, Yun Zhou, Xue Feng, Zilong Wu, Yongqiang Yang… in Cell Death & Disease (2024)

Article

AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer

Aurora-A kinase interacting protein 1 (AURKAIP1) has been proved to take an intermediary role in cancer by functioning as a negative regulator of Aurora-A kinase. However, it remains unclear whether and how AU...

Wenwen Tian, Yuhui Tang, Yongzhou Luo, **dong **e, Shaoquan Zheng… in Cell Death & Disease (2023)

Article

Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation

Excessive osteoclast formation and bone resorption are related to osteolytic diseases. Delta drosophila homolog-like 2 (Dlk2), a member of the epidermal growth factor (EGF)-like superfamily, reportedly regulat...

**nwei Chen, Xuzhuo Chen, Rui Chao, Yexin Wang, Yi Mao, Baoting Fan… in Cell Death & Disease (2023)

Article

Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporters

Naturally occurring fluorescent proteins (FPs) are the most widely used tools for tracking cellular proteins and sensing cellular events. Here, we chemically evolved the self-labeling SNAP-tag into a palette o...

Dasheng Zhang, Zhengda Chen, Zengmin Du, Bingkun Bao, Ni Su, **anjun Chen… in Cell Discovery (2023)

Article

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m⁵C methylation

5-methylcytosine (m⁵C) modification, which is mainly induced by the RNA methyltransferase NSUN2 (NOP2/Sun domain family, member 2), is an important chemical posttranscriptional modification in mRNA and has been p...

Min Yang, Renxiong Wei, Sheng Zhang, Sang Hu, **aoxiao Liang… in Cell Death & Disease (2023)

Article

Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway

Esophageal squamous cell carcinoma (ESCC) is characterized by high morbidity and mortality. Circular RNAs (circRNAs) play an important role in tumor progression. We discovered an aberrantly expressed circRNA (...

Fan Meng, **aokang Zhang, Yanting Wang, Jie Lin, Yulin Tang… in Cell Death & Disease (2023)

Article

Correction: Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats

**ang-Sheng Zhang, Qi Wu, Ling-Yun Wu, Zhen-Nan Ye, Tian-Wei Jiang… in Cell Death & Disease (2022)

Article

CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway

Cancer-associated fibroblasts (CAFs) are the most abundant stromal components in the tumor microenvironment (TME) and closely involved in tumor progression. However, the precise biological functions and molecu...

Peng Yang, Dongsheng Zhang, Tuo Wang, Jiangzhou Ji, Chi **… in Cell Death & Disease (2022)

Article

Correction: Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model

**aobo Han, Jean de Dieu Habimana, Amy L. Li, Rongqi Huang… in Cell Death & Disease (2022)

Article

Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model

Defects in ataxin-3 proteins and CAG repeat expansions in its coding gene ATXN3 cause Spinocerebellar Ataxia Type 3 (SCA3) or Machado-Joseph disease (MJD) polyglutamine neurodegenerative disease. The mutant pr...

**aobo Han, Jean de Dieu Habimana, Amy L. Li, Rongqi Huang… in Cell Death & Disease (2022)

Article

Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction

Mechanotransduction sensing of tissue architecture and cellular microenvironment is a fundamental regulator of cell fate, including cancer. Meanwhile, long noncoding RNAs (lncRNAs) play multifunctions during c...

Lijun Zheng, Chenyu Luo, Nan Yang, Hailong Pei, Mintao Ji… in Cell Death & Disease (2022)

Article

Correction to: ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway

Dafeng Xu, Yu Wang, **cai Wu, Zhensheng Zhang, Jiacheng Chen… in Cell Death & Disease (2022)

Article

The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders

Autophagy is a conserved method of quality control in which cytoplasmic contents are degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid metabolism, has recently received...

Sheng Zhang, Xueqiang Peng, Shuo Yang, **nyu Li, Mingyao Huang… in Cell Death & Disease (2022)

Article

SLC25A1 promotes tumor growth and survival by reprogramming energy metabolism in colorectal cancer

Abnormal lipid metabolism has been commonly observed in various human cancers, including colorectal cancer (CRC). The mitochondrial citrate carrier SLC25A1 (also known as mitochondrial citrate/isocitrate carri...

Ying Yang, Jiaxing He, Bo Zhang, Zhansheng Zhang, Guozhan Jia… in Cell Death & Disease (2021)

Article

Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK

Obesity is an epidemic affecting 13% of the global population and increasing the risk of many chronic diseases. However, only several drugs are licensed for pharmacological intervention for the treatment of ob...

Ruoxuan Bao, Yongmei Meng, Haibo Zhang, Chen Yang, Wei Li… in Cell Death & Disease (2021)

Article

Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer

Long noncoding ribonucleic acids (LncRNAs) have been found to be involved in the proliferation, apoptosis, invasion, migration, and other pathological processes of triple-negative breast cancer (TNBC). Express...

**aohui Zhang, Fangyuan Li, Yidong Zhou, Feng Mao, Yan Lin… in Cell Death & Disease (2021)

Article

SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1

Breast cancer is the most common cancer in women and its incidence rates are rapidly increasing in China. Understanding the molecular mechanisms of breast cancer tumorigenesis enables the development of novel ...

**g**g Ma, Zhixian He, Hongwei Zhang, Wensheng zhang, Sheng Gao… in Cell Death & Disease (2021)

Article

CircRNA circ_0124554 blocked the ubiquitination of AKT promoting the skip lymphovascular invasion on hepatic metastasis in colorectal cancer

Colorectal cancer (CRC) is the fourth most common cancer in men and the third most common cancer in women worldwide. The incidence and mortality of CRC was increasing rapidly in China. Lymph node-negative colo...

Junwei Tang, Chuan Zhang, Yuanjian Huang, Lu Wang, Ziwei Xu… in Cell Death & Disease (2021)