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Open AccessATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis
Acute pancreatitis (AP), an acute inflammatory process, can be difficult to diagnose. Activating transcription factor 4 (ATF4) has been reported to participate in the pathogenesis of AP. Additionally, histone ...
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Article
Open AccessOutcome of robot-assisted pancreaticoduodenectomy during initial learning curve versus laparotomy
To analyze the initial learning curve (LC) for robot-assisted pancreaticoduodenectomy (RAPD) and compare RAPD during the initial LC with open pancreaticoduodenectomy (OPD) in terms of outcome. This study is a ...
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Article
Correction to: Ready player one? Autophagy shapes resistance to photodynamic therapy in cancers
The below funding information was not submitted and hence not included in the original publication. The funding information is given below.
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Article
Ready player one? Autophagy shapes resistance to photodynamic therapy in cancers
Photodynamic therapy (PDT) is a procedure used in cancer therapy that has been shown to be useful for certain indications. Considerable evidence suggests that PDT might be superior to conventional modalities f...
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Article
Open AccessSerotonin and YAP/VGLL4 Balance Correlated with Progression and Poor Prognosis of Hepatocellular Carcinoma
YAP-TEAD complex plays an important role in tumorigenesis. 5-HT is proved to upregulate YAP expression by our previous study and VGLL4 is found to compete with YAP for binding to TEAD in several of cancers. He...
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Open AccessExpression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance
This study investigated UGP2 (uridine diphosphate-glucose pyrophosphorylase-2) and CFL1 (cofilin-1) expression in pancreatic ductal carcinoma (PDC), paracancerous tissue (PT), benign lesions (BL), and normal t...
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Article
Open AccessInvestigation of Copper Cysteamine Nanoparticles as a New Type of Radiosensitiers for Colorectal Carcinoma Treatment
Copper Cysteamine (Cu-Cy) is a new photosensitizer and a novel radiosensitizer that can be activated by light, X-ray and microwave to produce singlet oxygen for cancer treatment. However, the killing mechanism...
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Article
Open AccessSYNJ2BP inhibits tumor growth and metastasis by activating DLL4 pathway in hepatocellular carcinoma
Synaptojanin 2 Binding Protein (SYNJ2BP) is essential to cell proliferation. Previous studies show that SYNJ2BP participates in sprouting angiogenesis, which plays an important part in several abnormal conditi...
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Article
The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance
Gallbladder cancers (GBCs) are highly malignant gastrointestinal cancers. The biological makers for the prognosis and targeting therapy of GBCs have not been established. The protein expression of Notch 1 and ...
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Article
GmSGR1, a stay-green gene in soybean (Glycine max L.), plays an important role in regulating early leaf-yellowing phenotype and plant productivity under nitrogen deprivation
Chlorophyll (Chl) degradation is closely associated with leaf senescence and plays an important role in mediating photosynthetic capacity of the plants. In this study, GmSGR1, a SGR1 type of stay-green (SGR) gen...
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Article
Open AccessGemcitabine plus cisplatin versus gemcitabine alone in the treatment of pancreatic cancer: a meta-analysis
Pancreatic cancer ranks as the fourth leading cause of cancer-related mortality in the USA. And gemcitabine has been the standard of care for advanced pancreatic cancer. However, a combined use of gemcitabine ...
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The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with intrinsic resistance to cytotoxic agents. The molecular mechanisms associated with high malignancy and resistance to chemotherapy and ra...
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Article
ATP5b and β2-microglobulin are predictive markers for the prognosis of patients with gallbladder cancer
The differences in clinical, pathological, and biological characteristics between adenocarcinoma (AC) and squamous cell/adenosquamous carcinoma (SC/ASC) of the gallbladder have not been well documented. This s...
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Article
Open AccessNT5E and FcGBP as key regulators of TGF-1-induced epithelial–mesenchymal transition (EMT) are associated with tumor progression and survival of patients with gallbladder cancer
Epithelial–mesenchymal transitions (EMTs) are essential manifestations of epithelial cell plasticity during tumor progression. Transforming growth factor-β(TGF-β) modulates epithelial plasticity in tumor physi...
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Article
Angiotensin II Induces Endothelin-1 Expression in Human Hepatic Stellate Cells
Both angiotensin (Ang)-II and endothelin-1 (ET-1) are involved in the pathogenesis of liver fibrosis. Activated hepatic stellate cells (HSCs) are considered a key effector of liver fibrosis.
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Open AccessAssociation of BDNF and BMPR1A with clinicopathologic parameters in benign and malignant gallbladder lesions
Neurotrophic factors such as brain derived neurotrophic factor (BDNF) are synthesized in a variety of neural and non-neuronal cell types and regulate survival, proliferation and apoptosis. In addition, bone mo...
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Article
Application of butane geochemistry of natural gas in hydrocarbon exploration
In order to distinguish the source and migration direction of natural gas by geochemical characteristics of butane, the components and carbon isotopes of natural gas from major hydrocarbonbearing basins in Chi...
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Article
Open AccessExpression levels of HMGA2 and CD9 and its clinicopathological significances in the benign and malignant lesions of the gallbladder
The objective of this study was to investigate CD9 and HMGA2 expression and its clinicopathological significance in benign and malignant lesion tissues of the gallbladder.
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Article
Clinicopathologic and Prognostic Significance of CD24 in Gallbladder Carcinoma
CD24, a small cell surface protein, has emerged as a novel oncogene and prognostic factor for poor outcomes in many human cancers. However, the association of CD24 expression pattern in gallbladder carcinoma w...
