84 Result(s)
within
**ong-rui Wang
Life Sciences
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Article
Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice
Dietary restriction (DR) is a potential intervention for ameliorating ageing-related damages. Mitochondrial quality control is the key mechanism for regulating cellular functions in skeletal muscle. This study...
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m6A demethylation of FOSL1 mRNA protects hepatoma cells against necrosis under glucose deprivation
Stress-adaptive mechanisms enabling cancer cells to survive under glucose deprivation remain elusive. N6-methyladenosine (m6A) modification plays important roles in determining cancer cell fate and cellular stres...
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Article
Open AccessExploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet
Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy ...
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Community of Arbuscular Mycorrhizal Fungi in the Rhizosphere Soils with Different Generations of Hybridized Progeny of Wild Erianthus arundinaceus and Sugarcane
This study aimed to explore the community of arbuscular mycorrhizal fungi (AMF) in the rhizosphere soil with different generations of the hybridized progeny of wild Erianthus arundinaceus and sugarcane. Rhizosphe...
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Article
Integration of the Metabolome and Transcriptome Reveals Diurnal Variability in the Effects of Melatonin on Salt Tolerance in Maize Seedlings
Salt hazard is one of the major environmental stresses that seriously threaten world food security. Although melatonin has been proven to improve stress tolerance in plants, the metabolic changes and gene tran...
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Open AccessThrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease
The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...
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Open AccessIP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway
Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca2+) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...
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Article
The Community of Arbuscular Mycorrhizal Fungi in Sugarcane Rhizosphere Soils in Guangxi, China
In order to analyze the community of the arbuscular mycorrhizal fungi (AMF) in the rhizosphere soil and roots of sugarcane in Guangxi, China, this study analyzed the 18S rDNA gene sequences, soil physicochemic...
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Article
Artemisia argyi H. Lév. & Vaniot: a comprehensive review on traditional uses, phytochemistry, and pharmacological activities
Artemisia argyi, a perennial herb of the genus Artemisia, is recorded as medicine for the treatment of various diseases, such as metrorrhagia, menorrhagia, irregular menstruation, hemorrhage, dysmenorrhea, eczema...
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Article
Classification of Glomerular Pathology Images in Children Using Convolutional Neural Networks with Improved SE-ResNet Module
Classification of glomerular pathology based on histology sections is the key to diagnose the type and degree of kidney diseases. To address problems in the classification of glomerular lesions in children, a ...
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Article
Effects of Mixed Crop** on Sugarcane Growth and the Community of Arbuscular Mycorrhizal Fungi
To explore the effects of mixed crop** of different sugarcane varieties on the growth of sugarcane and the community structure of arbuscular mycorrhizal fungi (AMF), field experiments were conducted using RO...
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Article
Open AccessTargeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer
Lung cancer is the leading cause of cancer-related mortality worldwide. CNOT3, a subunit of the CCR4-NOT complex, has recently been suggested to be overexpressed in lung cancer and involved in tumor malignancy...
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Article
RUNDC1 inhibits autolysosome formation and survival of zebrafish via clas** ATG14-STX17-SNAP29 complex
Autophagy serves as a pro-survival mechanism for a cell or a whole organism to cope with nutrient stress. Our understanding of the molecular regulation of this fusion event remains incomplete. Here, we identif...
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Article
Functional screening and rational design of compounds targeting GPR132 to treat diabetes
Chronic inflammation due to islet-residing macrophages plays key roles in the development of type 2 diabetes mellitus. By systematically profiling intra-islet lipid–transmembrane receptor signalling in islet-r...
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Article
Citrus medica var. Sarcodactylus (Siebold ex Hoola van Nooten) Swingle: an insight into its botany, traditional uses, phytochemistry, and pharmacological properties
Citrus medica var. sarcodactylus (Siebold ex Hoola van Nooten) Swingle is not only a delicious fruit with rich nutrients, but also a traditional Chinese medicine with clinical values. The botanical characteristic...
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Open AccessCuticular competing endogenous RNAs regulate insecticide penetration and resistance in a major agricultural pest
The continuously develo** pesticide resistance is a great threat to agriculture and human health. Understanding the mechanisms of insecticide resistance is a key step in dealing with the phenomenon. Insect c...
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Article
AIWW: a new nutrition-screening tool for the oncologic population
Malnutrition is a common comorbidity among patients with cancer. However, no nutrition-screening tool has been recognized in this population. A quick and easy screening tool for nutrition with high sensitivity...
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Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN–pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation under hypoxia. Here we identify RI...
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Open AccessMicroglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1
Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is...
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Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
