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TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

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  1. Article

    Open Access

    Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer

    Lung cancer is the leading cause of cancer-related mortality worldwide. CNOT3, a subunit of the CCR4-NOT complex, has recently been suggested to be overexpressed in lung cancer and involved in tumor malignancy...

    Lin **g, Meng-En Zhai, Mei-Rui Qian, Yi-Ming Li, Ming-Wei Han… in Cell Death Discovery (2023)

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  2. Article

    Open Access

    IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway

    Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca2+) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...

    Qing-Rui Wu, Hui Yang, Hui-Dan Zhang, Yong-Jiang Cai… in Cell Death Discovery (2024)

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  3. Article

    Open Access

    Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

    The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...

    **ao-yun Niu, **-xiu **e, Hou-zhen Tuo, Cui-** Lv, Ya-ru Huang… in Cell Death Discovery (2024)

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