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  1. No Access

    Article

    Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice

    Dietary restriction (DR) is a potential intervention for ameliorating ageing-related damages. Mitochondrial quality control is the key mechanism for regulating cellular functions in skeletal muscle. This study...

    Ting-Rui Zhang, Chun-Hsien Chiang, Tzu-Chieh Hsu, Chih-Yun Wang… in Biogerontology (2024)

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    Article

    Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation

    The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN–pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation under hypoxia. Here we identify RI...

    Tao Zhang, Daichao Xu, Jian** Liu, Min Wang, Li-Juan Duan, Min Liu… in Nature Cell Biology (2023)

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    Article

    TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

    The receptor-regulated Smad proteins are essential intracellular mediators of signal transduction by the transforming growth factor-β (TGF-β) superfamily of growth factors and are also important as regulators ...

    Shirin Bonni, Hong-Rui Wang, Carrie G. Causing, Peter Kavsak… in Nature Cell Biology (2001)