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Article
Relationship between bleeding sites and clinical data: experience of 646 epistaxis cases in 8 years
This study aims to investigate the bleeding sites and their relationship with clinical characteristics in hospitalized epistaxis patients.
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Article
SHFW: second-order hybrid fusion weight–median algorithm based on machining learning for advanced IoT data analytics
IoT applications have greatly improved the convenience of our lives, generating large amounts of IoT data. How to efficiently use these data to feed IoT applications has become a significant research problem, ...
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Article
Overexpressing lnc240 Rescues Learning and Memory Dysfunction in Hepatic Encephalopathy Through miR-1264-5p/MEF2C Axis
Hepatic encephalopathy (HE) is a nervous system disease caused by severe liver diseases and different degrees of learning and memory dysfunction. Long non-coding RNA (lncRNA) is highly expressed in the brain a...
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Article
Correction to: USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization
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Article
Open AccessAuthor Correction: The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair
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Article
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. Characterization of genetic alterations will improve our understanding and therapies for this disease. Here, we report that PDAC with ...
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Article
Open AccessRNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
BRCA1-BARD1 heterodimers act in multiple steps during homologous recombination (HR) to ensure the prompt repair of DNA double strand breaks. Dysfunction of the BRCA1 pathway enhances the therapeutic efficiency...
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Article
Mucus composition abnormalities in sinonasal mucosa of chronic rhinosinusitis with and without nasal polyps
Mucus secretion and its composition are vital in the maintenance of airway health, among which hypoxia-inducible factors (HIFs) are thought to be involved in the regulation of mucin synthesis and regulation. N...
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Article
Open AccessAnticholinergic Burden and Associated Healthcare Resource Utilization in Older Adults with Overactive Bladder
Bladder anticholinergics are the most widely used drugs to treat overactive bladder (OAB) but can contribute to cumulative anticholinergic burden, which may be associated with adverse outcomes.
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Article
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection
The shieldin complex functions as the downstream effector of 53BP1–RIF1 to promote DNA double-strand break end-joining by restricting end resection. The SHLD2 subunit binds to single-stranded DNA ends and bloc...
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Article
Open AccessReciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
The RNA-sensing pathway contributes to type I interferon (IFN) production induced by DNA damaging agents. However, the potential involvement of RNA sensors in DNA repair is unknown. Here, we found that retinoi...
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Article
Open AccessUSP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP
Human C-terminal binding protein (CtBP)–interacting protein (CtIP) is a central regulator to initiate DNA end resection and homologous recombination (HR). Several studies have shown that post-translational mod...
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Article
Author Correction: Regulation of sister chromatid cohesion by nuclear PD-L1
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessRegulation of sister chromatid cohesion by nuclear PD-L1
Programmed death ligand-1 (PD-L1 or B7-H1) is well known for its role in immune checkpoint regulation, but its function inside the tumor cells has rarely been explored. Here we report that nuclear PD-L1 is imp...
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Article
Open AccessThe bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair
Homologous recombination (HR) is important for error-free DNA double strand break repair and maintenance of genomic stability. However, upregulated HR is also used by cancer cells to promote therapeutic resist...
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Article
Open AccessA novel UCHL3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair
Triple-negative breast cancer (TNBC) treatment remains a great challenge for clinical practice and novel therapeutic strategies are urgently needed. UCHL3 is a deubiquitinase that is overexpressed in TNBC and ...
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Article
Open AccessUFL1 promotes histone H4 ufmylation and ATM activation
The ataxia-telangiectasia mutated (ATM) kinase, an upstream kinase of the DNA damage response (DDR), is rapidly activated following DNA damage, and phosphorylates its downstream targets to launch DDR signaling...
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Chapter and Conference Paper
Topologically-Guided Color Image Enhancement
Enhancement is an important step in post-processing digital images for personal use, in medical imaging, and for object recognition. Most existing manual techniques rely on region selection, similarity, and/o...
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Chapter and Conference Paper
Propagate and Pair: A Single-Pass Approach to Critical Point Pairing in Reeb Graphs
With the popularization of Topological Data Analysis, the Reeb graph has found new applications as a summarization technique in the analysis and visualization of large and complex data, whose usefulness extend...
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Article
USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization
β-catenin is a major transcriptional activator of the canonical Wnt/β-catenin signaling pathway. It is important for a series of biological processes including tissue homeostasis, and embryonic development and...
