1,093 Result(s)
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Article
Open AccessReformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation
Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this. Here, we reformu...
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Open AccessReducing nonradiative recombination for highly efficient inverted perovskite solar cells via a synergistic bimolecular interface
Reducing interface nonradiative recombination is important for realizing highly efficient perovskite solar cells. In this work, we develop a synergistic bimolecular interlayer (SBI) strategy via 4-methoxypheny...
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Open AccessMiddle and Late Pleistocene Denisovan subsistence at Baishiya Karst Cave
Genetic and fragmented palaeoanthropological data suggest that Denisovans were once widely distributed across eastern Eurasia1–3. Despite limited archaeological evidence, this indicates that Denisovans were capab...
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Open AccessHiTE: a fast and accurate dynamic boundary adjustment approach for full-length transposable element detection and annotation
Recent advancements in genome assembly have greatly improved the prospects for comprehensive annotation of Transposable Elements (TEs). However, existing methods for TE annotation using genome assemblies suffe...
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Open AccessProfiling lipid mediators in serum from children with H1N1 influenza
Influenza A virus subtype H1N1 can cause severe acute respiratory distress syndrome and death in young children and elderly individuals. H1N1 initiates inflammatory responses that aim to contain and eliminate ...
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Open AccessMorphological and proteomic study of waterlogging tolerance in cotton
Floating seedling cultivation technique is a novel seedling method in cotton and it provides an ideal model to study cotton growing under waterlogging stress. Morphological character and proteomic profile of t...
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Open AccessRelationships between students’ perceived campus walkability, mental health, and life satisfaction during COVID-19
Improving walkability in the campus environment and socio-psychological environments can promote students’ mental health and subjective well-being. This study aimed to propose a theoretical model to investigat...
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Open AccessBoswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin
Breast cancer (BC) remains a significant health concern for women globally, prompting the relentless pursuit of novel therapeutic modalities. As a traditional Chinese medicine, Boswellia carterii has been extensi...
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Open AccessEffect of tissue tension on magnetic compression anastomosis of digestive tract
With the increasing application of magnetic compression anastomosis (MCA) in gastrointestinal anastomosis, we identified an interesting phenomenon that an anastomosis is more prone to stenosis after endoscopic...
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Open AccessInhibiting perovskite decomposition by a creeper-inspired strategy enables efficient and stable perovskite solar cells
The commercialization of perovskite solar cells is badly limited by stability, an issue determined mainly by perovskite. Herein, inspired by a natural creeper that can cover the walls through suckers, we adopt...
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Open AccessTranscriptomic profiling highlights cell proliferation in the progression of experimental pulmonary hypertension in rats
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary vascular remolding and occlusion, leading to the elevated pulmonary arterial pressures, right ventricular hypertrophy, ...
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Open AccessAcetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors
Despite the importance of spliceosome core components in cellular processes, their roles in cancer development, including hepatocellular carcinoma (HCC), remain poorly understood. In this study, we uncover a c...
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Open AccessEpistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin
The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe that mutations G186D and D190N in the hemagglutinin ...
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Open AccessIn-tube micro-pyramidal silicon nanopore for inertial-kinetic sensing of single molecules
Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in...
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Open AccessCFD–DEM method is used to study the multi-phase coupling slag discharge flow field of gas-lift reverse circulation in drilling shaft sinking
To elucidate the distribution law of the multiphase coupling slag discharge flow field in gas-lift reverse circulation during drilling shaft sinking, a numerical analysis model of gas–liquid–solid multiphase c...
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Open AccessPCK1-mediated glycogenolysis facilitates ROS clearance and chemotherapy resistance in cervical cancer stem cells
Cervical cancer, one of the most common gynecological cancers, is primarily caused by human papillomavirus (HPV) infection. The development of resistance to chemotherapy is a significant hurdle in treatment. I...
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Open AccessDivergence and convergence: a cross-generational study on local food consumption
In the context of the expanding local food market, gras** the evolutionary trajectory of consumer purchasing behavior is crucial for understanding market dynamics. This study adopts a cross-generational pers...
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Open AccessOptimization design of battery bracket for new energy vehicles based on 3D printing technology
Nowadays, what captures consumers' primary attention is how to purchase electric vehicles with long range and desirable price. Lightweight construction stands as one of the most effective approaches for prolon...
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Open AccessLow complexity beamforming design in reconfigurable intelligent surface-assisted communication systems
Due to the possibility of blockage during communication, the communication quality may be poor. Therefore, Reconfigurable Intelligent Surface (RIS) technology can effectively solve this problem. In order to in...
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Open AccessAn effective and rapidly degradable disinfectant from disinfection byproducts
Chloroxylenol is a worldwide commonly used disinfectant. The massive consumption and relatively high chemical stability of chloroxylenol have caused eco-toxicological threats in receiving waters. We noticed th...
