7 Result(s)
within
**ntao Deng
Cancer Research
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Article
Open AccessDeep whole genome sequencing identifies recurrent genomic alterations in commonly used breast cancer cell lines and patient-derived xenograft models
Breast cancer cell lines (BCCLs) and patient-derived xenografts (PDXs) are the most frequently used models in breast cancer research. Despite their widespread usage, genome sequencing of these models is incomp...
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Article
Open AccessEvaluation of FGFR targeting in breast cancer through interrogation of patient-derived models
Particular breast cancer subtypes pose a clinical challenge due to limited targeted therapeutic options and/or poor responses to the existing targeted therapies. While cell lines provide useful pre-clinical mo...
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Article
Open AccessTumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC
Patients diagnosed with triple negative breast cancer (TNBC) have an increased risk of rapid metastasis compared to other subtypes. Predicting long-term survival post-chemotherapy in patients with TNBC is diff...
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Article
Open AccessAbundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma
Gastric cancer, a leading cause of cancer death worldwide, has been little studied compared with other cancers that impose similar health burdens. Our goal is to assess genomic copy-number loss and the possib...
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Open AccessMicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene
The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary devel...
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Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
Patrick Tan, Bin Tean Teh, Steve Rozen and colleagues report recurrent somatic mutations in the cell-adhesion gene FAT4 and the chromatin-remodeling gene ARID1A in gastric adenocarcinomas. Their data suggest that...
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Article
Clinical and therapeutic relevance of PIM1 kinase in gastric cancer
Gastric cancer is a leading cause of cancer-related mortality, and chemotherapeutic options are currently limited. PIM1 kinase, an oncogene that promotes tumorigenesis in several cancer types, might represent ...
