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Open AccessA machine-learning algorithm using claims data to identify patients with homozygous familial hypercholesterolemia
Homozygous familial hypercholesterolemia (HoFH) is an underdiagnosed and undertreated ultra-rare disease. We utilized claims data from the Komodo Healthcare Map database to develop a machine-learning model to ...
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Article
Open AccessOptogenetic manipulation and photoacoustic imaging using a near-infrared transgenic mouse model
Optogenetic manipulation and optical imaging in the near-infrared range allow non-invasive light-control and readout of cellular and organismal processes in deep tissues in vivo. Here, we exploit the advantage...
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Article
Open AccessMitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe
Mitochondria play a critical role in generating energy to support the entire lifecycle of biological cells, yet it is still unclear how their morphological structures evolve to regulate their functionality. Co...
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Article
Amplified stimulated emission in upconversion nanoparticles for super-resolution nanoscopy
Super-resolution optical microscopy based on stimulated emission depletion effects can now be performed at much lower light intensities than before by using bright upconversion emission from thulium-doped nano...
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Article
Open AccessThree-dimensional controlled growth of monodisperse sub-50 nm heterogeneous nanocrystals
The ultimate frontier in nanomaterials engineering is to realize their composition control with atomic scale precision to enable fabrication of nanoparticles with desirable size, shape and surface properties. ...