5 Result(s)
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Article
Open AccessThe AAA-ATPase Ter94 regulates wing size in Drosophila by suppressing the Hippo pathway
Insect wing development is a fascinating and intricate process that involves the regulation of wing size through cell proliferation and apoptosis. In this study, we find that Ter94, an AAA-ATPase, is essential...
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Article
Open AccessSPOP point mutations regulate substrate preference and affect its function
The adaptor SPOP recruits substrates to CUL3 E3 ligase for ubiquitination and degradation. Structurally, SPOP harbors a MATH domain for substrate recognition, and a BTB domain responsible for binding CUL3. Rep...
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Article
Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration
Although the Hedgehog (Hh) pathway plays an evolutionarily conserved role from Drosophila to mammals, some divergences also exist. Loss of Sufu, an important component of the Hh pathway, does not lead to an obvio...
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Article
Open AccessUsp8 promotes tumor cell migration through activating the JNK pathway
Tumor metastasis is the most cause of high mortality for cancer patients. Identification of novel factors that modulate tumor cell migration is of great significance for therapeutic strategies. Here, we find t...
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Article
Open AccessHippo signaling suppresses tumor cell metastasis via a Yki-Src42A positive feedback loop
Metastasis is an important cause of death from malignant tumors. It is of great significance to explore the molecular mechanism of metastasis for the development of anti-cancer drugs. Here, we find that the Hi...
