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Article
Open AccessThe AAA-ATPase Ter94 regulates wing size in Drosophila by suppressing the Hippo pathway
Insect wing development is a fascinating and intricate process that involves the regulation of wing size through cell proliferation and apoptosis. In this study, we find that Ter94, an AAA-ATPase, is essential...
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Article
Open AccessSPOP point mutations regulate substrate preference and affect its function
The adaptor SPOP recruits substrates to CUL3 E3 ligase for ubiquitination and degradation. Structurally, SPOP harbors a MATH domain for substrate recognition, and a BTB domain responsible for binding CUL3. Rep...
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Article
Open AccessEffects of climate factors and Demodex infestation on meibomian gland dysfunction-associated dry eye diseases
We examined the effects of climatic factors and Demodex infestations on meibomian gland dysfunction (MGD)-associated dry eye disease (DED) in a cross-sectional study. This study included 123 patients from Tian...
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Article
Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration
Although the Hedgehog (Hh) pathway plays an evolutionarily conserved role from Drosophila to mammals, some divergences also exist. Loss of Sufu, an important component of the Hh pathway, does not lead to an obvio...
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Chapter and Conference Paper
Research on Evaluation of Construction Workers’ Job Satisfaction Based on Improved AHP-FCE Method
In the post-epidemic era, the construction industry has been greatly impacted, and the wave of labor shortages in the construction industry has reappeared. The construction industry has frequently faced the pr...
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Article
Open AccessUsp8 promotes tumor cell migration through activating the JNK pathway
Tumor metastasis is the most cause of high mortality for cancer patients. Identification of novel factors that modulate tumor cell migration is of great significance for therapeutic strategies. Here, we find t...
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Article
Open AccessHippo signaling suppresses tumor cell metastasis via a Yki-Src42A positive feedback loop
Metastasis is an important cause of death from malignant tumors. It is of great significance to explore the molecular mechanism of metastasis for the development of anti-cancer drugs. Here, we find that the Hi...
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Article
The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer
E3 ligases are a class of critical enzymes that can catalyse the transfer of ubiquitin (Ub) from an E2 enzyme to the substrate and are essential to cellular processes. The E3 ligase HUWE1 (also known as ARF-BP...
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Chapter and Conference Paper
Electromechanical and Thermal Synthesis Analysis of Spaceborne Active Phased Array Antenna
The general design principles and requirements of large-scale satellite antennas include indicators of mechanical, electrical, thermal, environmental and reliability. With the development of satellite technolo...
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Article
Design of Electromagnetic Vibration-Type Single-Bud Sugarcane Seed Metering Device
The objectives of this research were to solve the problem that the existing sugarcane seed metering device had high per cent of damaged seeds and omission rate. An electromagnetic vibration-type single-bud sug...
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Chapter and Conference Paper
Sugarcane Node Identification Based on Structured Learning Model
Sugarcane node identification is the key techniques for sugarcane cultivation mechanization. The accurate position of nodes that link two consecutive sections should be detected and transferred to microcontrol...
