-
Article
Open AccessMethamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats
Psychostimulant methamphetamine (METH) is neurotoxic to the brain and, therefore, its misuse leads to neurological and psychiatric disorders. The gene regulatory network (GRN) response to neurotoxic METH binge...
-
Article
Superpixel-based foreground-preserving image stitching
Image stitching aims to stitch multiple images with overlap** areas into a high-resolution image with natural appearance, no ghosting and no seam, so as to obtain a wide field of vision. And the stitching is...
-
Article
Open AccessCommon DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis
Trends in altered DNA methylation have been defined across human cancers, revealing global loss of methylation (hypomethylation) and focal gain of methylation (hypermethylation) as frequent cancer hallmarks. A...
-
Article
Open AccessTissue-specific usage of transposable element-derived promoters in mouse development
Transposable elements (TEs) are a significant component of eukaryotic genomes and play essential roles in genome evolution. Mounting evidence indicates that TEs are highly transcribed in early embryo developme...
-
Article
Open AccessComparison of differential accessibility analysis strategies for ATAC-seq data
ATAC-seq is widely used to measure chromatin accessibility and identify open chromatin regions (OCRs). OCRs usually indicate active regulatory elements in the genome and are directly associated with the gene r...
-
Article
Open AccessRapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails
Sheep have developed the ability to store fat in their tails, which is a unique way of reserving energy to survive a harsh environment. However, the mechanism underlying this adaptive trait remains largely uns...
-
Article
Open AccessEvaluation of functionality for serine and threonine phosphorylation with different evolutionary ages in human and mouse
Rapid evolution of phosphorylation sites could provide raw materials of natural selection to fit the environment by rewiring the regulation of signal pathways. However, a large part of phosphorylation sites wa...
-
Article
Open AccessCorrection: Corrigendum: Prioritizing functional phosphorylation sites based on multiple feature integration
Scientific Reports 6: Article number: 24735 published online: 19 April 2016; updated: 27 June 2016. The original version of this Article contained typographical errors in the Predict Functional Phosphosites we...
-
Article
Open AccessPrioritizing functional phosphorylation sites based on multiple feature integration
Protein phosphorylation is an important type of post-translational modification that is involved in a variety of biological activities. Most phosphorylation events occur on serine, threonine and tyrosine resid...
-
Chapter and Conference Paper
Implementation and Demonstration of WAVE Networking Services for Intelligent Transportation Systems
Intelligent Transportation System has been a hot topic during the past decades. The Wireless Access in Vehicular Environments (WAVE) system is a radio communication system which is capable of providing safety,...