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Article
Exploring the Impact of Biodegradable and Nonbiodegradable Microplastic Particles on Pb Absorption in Maize
The aim of this study was to explore the effects of the variations in biodegradable and nonbiodegradable microplastic particles (MPs) on the absorption of lead (Pb) in maize.
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Article
Construction of a Cu2+-Responsive NIR Fluorescent Probe and the Preliminary Evaluation of its Multifunctional Application
Cu2+ was deemed as toxic and the most common heavy metal pollution in the water and food. Meanwhile, endogenous Cu2+ was deeply involved in plenty of physiological and pathological processes of human. Cu2+ imbala...
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Article
Open AccessHybrid-FHR: a multi-modal AI approach for automated fetal acidosis diagnosis
In clinical medicine, fetal heart rate (FHR) monitoring using cardiotocography (CTG) is one of the most commonly used methods for assessing fetal acidosis. However, as the visual interpretation of CTG depends ...
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Article
Development of a H2S-responsive NIR Fluorescent Probe for H2S Detection and H2S Releasing Monitoring From Prodrug
H2S was deemed as a toxic gradient in the realm of food and environment but plays pivotal pathophysiological roles in organisms. H2S instabilities and disturbances are always responsible for multiple disorders. W...
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Article
First-in-Human, Single-Ascending Dose and Food Effect Studies to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Cetagliptin, a Dipeptidyl Peptidase-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus
Cetagliptin is a highly selective dipeptidyl peptidase-4 inhibitor under development to treat type 2 diabetes mellitus. This first-in-human study was conducted to characterise the pharmacokinetics, pharmacodyn...
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Article
Open AccessMycophenolic Acid Exposure Optimization Based on Vitamin D Status in Children with Systemic Lupus Erythematosus: A Single-Center Retrospective Study
Systemic lupus erythematosus (SLE) can affect bone metabolism and homeostasis of serum electrolytes that are associated with abnormal levels of vitamin D. Mycophenolate mofetil (MMF) is a commonly used immunos...
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Article
The emerging role of circular RNAs in cardiovascular diseases
Cardiovascular disease (CVD) is one of the vital causes of morbidity and mortality, and the number of deaths from CVD has increased worldwide. Circular RNAs (circRNAs) is a novel type of endogenous noncoding R...
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Article
A cysteine protease of Babesia microti and its interaction with tick cystatins
Babesiosis is a tick-borne protozoonosis caused by Babesia, which can cause fever, hemolytic anemia, hemoglobinuria, and even death. Babesia microti is a parasite found in rodents and can be pathogenic to humans....
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Article
Radiolabeling and biological evaluation of 125I-Necitumumab for EGFR-targeted SPECT imaging
Radiolabeled epidermal growth factor receptor (EGFR) targeted antibody could be used for imaging EGFR expressing cancer. In this study, the SPECT probe 125I-Necitumumab were synthesized and evaluated for SPECT im...
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Article
Population pharmacokinetics of vancomycin and AUC-guided dosing in Chinese neonates and young infants
To develop a population pharmacokinetic (PK) model for vancomycin in Chinese neonates and infants less than 2 months of age (young infants) with a wide gestational age range, in order to determine the appropri...
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Records of Environmental Changes in Physical Geography
From the viewpoints of physical geography, river and lake terraces, glacial moraines, lake sediments, ice core, stalagmite, tree-rings, loess and paleo-soils, etc. provide broad materials and contain multi-pro...
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Article
Target attainment analysis and optimal sampling designs for population pharmacokinetic study on piperacillin/tazobactam in neonates and young infants
Population pharmacokinetic (popPK) analyses for piperacillin/tazobactam in neonates and infants of less than 2 months of age have been performed by our group previously. The results indicate that a dose of 44....
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Article
Pediastrum sensu lato (Chlorophyceae) assemblages from surface sediments of lakes and ponds on the Tibetan Plateau
Fossil coenobia of the green algae group Pediastrum are well preserved in lake sediments. Integrated ecological and paleolimnological research as a basis for more exact palaeoecological inferences, however, is l...
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Article
Open AccessClimate change on the Tibetan Plateau in response to shifting atmospheric circulation since the LGM
The Tibetan Plateau (TP) is primarily influenced by the northern hemispheric middle latitude Westerlies and the Indian summer monsoon (ISM). The extent, long-distance effects and potential long-term changes of...
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Article
Pollen-inferred Holocene vegetation and climate histories in Taro Co, southwestern Tibetan Plateau
A 310-cm-long sediment core, covering the last 10,200 years, was collected from Taro Co on the southwestern Tibetan Plateau and analyzed for pollen, grain size and total inorganic carbon content. The pollen da...
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Article
Open AccessStudy on essential oils from four species of Zhishi with gas chromatography–mass spectrometry
Citrus fruits are widely used as food and or for medicinal purposes, and they contain a host of active substances that contribute to health. The immature fruits of Citrus sinensis Osbeck and its cultivars (CS), C...
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Article
The unified extreme learning machines and discriminative random fields for automatic knee cartilage and meniscus segmentation from multi-contrast MR images
Segmenting articular cartilage and meniscus from magnetic resonance (MR) images is an essential task for the assessment of knee pathology. Most of the previous classification-based works for cartilage and meni...
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Article
Open AccessPalaeoecological and palaeoenvironmental significance of some important spores and micro-algae in Quaternary deposits
Spores of ferns and allied plants, and micro-algae frequently occur in abundance in Quaternary deposits, but their palaeoenvironmental significance is seldom evaluated. This paper presents morphological descri...
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Article
Super-resolution readout property of bismuth-doped antimony-based thin film as a functional mask for read-only memory
Bismuth-doped antimony-based (Sb100−x Bi x , x=2.46) thin films were presented as a functional mask for super-resolution readout of read-only memory (ROM). The pi...
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Article
Open AccessHydrodynamic process of Tibetan Plateau lake revealed by grain size: Case study of Pumayum Co
Under the background of global warming, some lakes on the Tibetan Plateau (TP) are potentially sensitive to temperature change. With a case study of Pumayum Co, where glacier meltwater is important to supply (...
