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  1. Article

    Open Access

    Cryo-EM structure of cyanophage P-SCSP1u offers insights into DNA gating and evolution of T7-like viruses

    Cyanophages, together with their host cyanobacteria, play important roles in marine biogeochemical cycles and control of marine food webs. The recently identified MPP-C (Marine Picocyanobacteria Podovirus clad...

    Lanlan Cai, Hang Liu, Wen Zhang, Shiwei **ao, Qinglu Zeng in Nature Communications (2023)

  2. Article

    Open Access

    Structure and proposed DNA delivery mechanism of a marine roseophage

    Tailed bacteriophages (order, Caudovirales) account for the majority of all phages. However, the long flexible tail of siphophages hinders comprehensive investigation of the mechanism of viral gene delivery. Here...

    Yang Huang, Hui Sun, Shuzhen Wei, Lanlan Cai, Liqin Liu in Nature Communications (2023)

  3. Article

    Open Access

    A holistic genome dataset of bacteria, archaea and viruses of the Pearl River estuary

    Estuaries are one of the most important coastal ecosystems. While microbiomes and viromes have been separately investigated in some estuaries, few studies holistically deciphered the genomes and connections of...

    Bu Xu, Fuyan Li, Lanlan Cai, Rui Zhang, Lu Fan, Chuanlun Zhang in Scientific Data (2022)

  4. Article

    Open Access

    Effects of Transcranial Direct Current Stimulation on effort during a working-memory task

    Transcranial Direct Current Stimulation (tDCS) has shown that stimulation of Dorsolateral Prefrontal Cortex (DLPFC) facilitates task performance in working-memory tasks. However, little is known about its pote...

    David Framorando, Tianlan Cai, Yi Wang, Alan J. Pegna in Scientific Reports (2021)

  5. Article

    Open Access

    Penicillin causes non-allergic anaphylaxis by activating the contact system

    Immediate hypersensitivity reaction (IHR) can be divided into allergic- and non-allergic-mediated, while “anaphylaxis” is reserved for severe IHR. Clinically, true penicillin allergy is rare and most reported ...

    Yuan Gao, Yixin Han, **aoyu Zhang, Qiaoling Fei, Ruijuan Qi, Rui Hou in Scientific Reports (2020)

  6. Article

    Open Access

    Shuang-Huang-Lian injection induces an immediate hypersensitivity reaction via C5a but not IgE

    Among traditional Chinese medicine injections, intravenous Shuang-Huang-Lian (IV-SHL) has the highest incidence of injection-induced immediate hypersensitivity reactions (IHRs). The precise mechanisms of IV-SH...

    Yuan Gao, Rui Hou, Yixin Han, Qiaoling Fei, Runlan Cai, Yun Qi in Scientific Reports (2018)

  7. Article

    Open Access

    The Three-Herb Formula Shuang-Huang-Lian stabilizes mast cells through activation of mitochondrial calcium uniporter

    Mast cells (MCs) are key effector cells of IgE-FcεRI- or MrgprX2-mediated signaling event. Shuang-Huang-Lian (SHL), a herbal formula from Chinese Pharmacopoeia, has been clinically used in type I hypersensitiv...

    Yuan Gao, Rui Hou, Qiaoling Fei, Lei Fang, Yixin Han, Runlan Cai in Scientific Reports (2017)