18 Result(s)

Article

WFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczema-like skin lesions, dry skin, severe itching, and recurrent recurrence. The whey acidic protein four-disulfide core domain g...

Guolin Li, Linna Gu, Fulei Zhao, Yawen Hu, **aoyan Wang… in Cell Death & Disease (2023)

Article

SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction

Defective execution of proteases and protease inhibitors that mediate abnormal signaling cascades is emerging as a key contributor to skin diseases, such as psoriasis. SerpinB7 is identified as a skin-specific...

Hua** Zheng, Linna Gu, Fulei Zhao, Chen Zhang, Zhen Wang… in Cell Death & Disease (2022)

Article

Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis

Acute liver failure (ALF) is a severe clinical syndrome characterized by massive death of hepatocytes in a short time, resulting in coagulopathy and hepatic encephalopathy, with a high mortality in patients wi...

Zhijie Li, Heming Wang, Jun** Zhu, Ning Nan, Yi Lin, Xuran Zhuang… in Cell Death Discovery (2022)

Article

Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex

Nuclear pore complex (NPC) mediates nucleocytoplasmic shuttling. Here we present single-particle cryo-electron microscopy structure of the inner ring (IR) subunit from the Xenopus laevis NPC at an average resolut...

Gaoxingyu Huang, **echao Zhan, Chao Zeng, Ke Liang, Xuechen Zhu… in Cell Research (2022)

Article

Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex

Nuclear pore complex (NPC) shuttles cargo across the nuclear envelope. Here we present single-particle cryo-EM structure of the nuclear ring (NR) subunit from Xenopus laevis NPC at an average resolution of 5.6 Å....

Gaoxingyu Huang, **echao Zhan, Chao Zeng, Xuechen Zhu, Ke Liang… in Cell Research (2022)

Article

CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini

High-throughput sequencing reveals the complex landscape of small noncoding RNAs (sRNAs). However, it is limited by requiring 5′-monophosphate and 3′-hydroxyl in RNAs for adapter ligation and hindered by methy...

Heming Wang, Rong Huang, Ling Li, Jun** Zhu, Zhihong Li, Chao Peng… in Cell Discovery (2021)

Article

Dynamic proteomic profiling of human periodontal ligament stem cells during osteogenic differentiation

Human periodontal ligament stem cells (hPDLSCs) are ideal seed cells for periodontal regeneration. A greater understanding of the dynamic protein profiles during osteogenic differentiation contributed to the i...

Jianjia Li, Zhifa Wang, **angyu Huang, Zhaodan Wang… in Stem Cell Research & Therapy (2021)

Article

Emerging role of the Hippo pathway in autophagy

Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromol...

Dongying Wang, Jiaxing He, Bingyu Huang, Shanshan Liu, Hongming Zhu… in Cell Death & Disease (2020)

Article

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

Bingbing He, Wenbo Peng, Jia Huang, Hang Zhang, Yingsi Zhou, **ali Yang… in Protein & Cell (2020)

Article

Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis

The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron m...

Gaoxingyu Huang, Yanqing Zhang, Xuechen Zhu, Chao Zeng, Qifan Wang… in Cell Research (2020)

Article

Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex

The nuclear pore complex (NPC) mediates the flow of substances between the nucleus and cytoplasm in eukaryotic cells. Here we report the cryo-electron tomography (cryo-ET) structure of the luminal ring (LR) of...

Yanqing Zhang, Sai Li, Chao Zeng, Gaoxingyu Huang, Xuechen Zhu, Qifan Wang… in Cell Research (2020)

Article

Short-term and long-term outcomes of liver resection for HCC patients with portal vein tumor thrombus

Portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) is a sign of advanced stage disease, which is associated with poor prognosis. Liver resection (LR) may provide better prognosis in selected...

Lei Huo, Wenxin Wei, Zhenlin Yan, Zhengqing Lei, Yanting **e… in Cell & Bioscience (2019)

Article

Homology-mediated end joining-based targeted integration using CRISPR/Cas9

Targeted integration of transgenes can be achieved by strategies based on homologous recombination (HR), microhomology-mediated end joining (MMEJ) or non-homologous end joining (NHEJ). The more generally used ...

Xuan Yao, **ng Wang, **nde Hu, Zhen Liu, Junlai Liu, Haibo Zhou… in Cell Research (2017)

Article

Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes

Acute liver failure (ALF) is a life-threatening illness. The extracorporeal cell-based bioartificial liver (BAL) system could bridge liver transplantation and facilitate liver regeneration for ALF patients by ...

**ao-Lei Shi, Yimeng Gao, Yupeng Yan, Hucheng Ma, Lulu Sun, Pengyu Huang… in Cell Research (2016)

Article

MAPK signaling in inflammation-associated cancer development

Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine kinases, which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms,...

Pengyu Huang, Jiahuai Han, Lijian Hui in Protein & Cell (2010)