30 Result(s)

Article

Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation

Palmitoylation of cysteine residues at the C-terminal hypervariable regions in human HRAS and NRAS, which is necessary for RAS signaling, is catalyzed by the acyltransferase DHHC9 in complex with its accessory...

Anlan Yang, Shengjie Liu, Yuqi Zhang, Jia Chen… in Nature Structural & Molecular Biology (2024)

Article

A bacteriophage against Citrobacter braakii and its synergistic effect with antibiotics

A bacteriophage BD49 specific for Citrobacter braakii was screened out and purified by double-layer plate method. It consists of a polyhedral head of 93.1 ± 1.2 nm long and 72.9 ± 4.2 nm wide, tail fibers, collar...

Siqi Liu, Hanyi Li, Zhihao Zhu, Mengjiao Wu, Mingxuan **… in Archives of Microbiology (2024)

Article

Transcriptomics Based Network Analyses and Molecular Docking Highlighted Potentially Therapeutic Biomarkers for Colon Cancer

In this study, machine learning-based multiple bioinformatics analysis was carried out for the purpose of the deep and efficient mining of high-throughput transcriptomics data from the TCGA database. Compared ...

Yun Wu, ** Dong, Jia Hu, Lingxiang Wang, Rongfang Xu… in Biochemical Genetics (2023)

Article

Sensitive and discriminative detection of cysteine by a Nile red-based NIR fluorescence probe

Cysteine (Cys) is a significant biological mercaptan that achieves key roles in several important physiological processes, such as reversible redox homeostasis in living organisms. Abnormal levels of Cys in th...

Junying Lv, **aorui Jiao, Di Demi He… in Analytical and Bioanalytical Chemistry (2023)

Article

Synthesis and biological activity of amide derivatives derived from natural product Waltherione F

Structural optimization based on natural products has become an effective way to develop new fungicides, which provides important guiding significance for practicing the new development concept and promoting t...

Hongbin Fang, Zhanfang Chen, Xuewen Hua, Wenrui Liu… in Medicinal Chemistry Research (2022)

Article

7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats

Whether 7,8-dihydroxyflavone (7,8-DHF), a tyrosine kinase receptor B (TrkB) agonist, modulates colonic smooth muscle motility and/or alleviates constipation has not yet been studied.

Li Ma, Zhiqiang Qu, Luo Xu, Lei Han, Qingfang Han… in Digestive Diseases and Sciences (2021)

Article

Transcriptome Sequencing Identifies Potential Biomarker for White Matter Lesions Diagnosis in the Hypertension Population

Hypertension is confirmed to be one of the major risk factors of leukoaraiosis (LA). However, the pathogenesis of LA is not completely understood and there is no reliable indicator for the early diagnosis of L...

Wendi Wang, Pei Sun, Fengyue Han, Chunjuan Wang, Yongxiang Wang… in Neurochemical Research (2021)

Article

Ratiometric fluorescence nanoplatform integrated with smartphone as readout device for sensing trace water

In our investigation, a smartphone-integrated ratiometric fluorescent sensing system with lanthanide-based infinite coordination polymers (Ce-GMP-DPA@Tb-DPA) as signal probe has been successfully constructed f...

Pengxiang Wang, Tianlin Wang, **nke Wang… in Analytical and Bioanalytical Chemistry (2021)

Article

A sensitive electrochemical DNA sensor for detecting Helicobacter pylori based on accordion-like Ti₃C₂Tx: a simple strategy

A novel electrochemical DNA sensor was designed to detect Helicobacter pylori based on accordion-like Ti₃C₂T_x. Here the multilayer Ti₃C₂T_x obtained by DMSO delamination was used to modify the glass carbon electro...

Luyan Wang, Kaili Cui, Pengxiang Wang… in Analytical and Bioanalytical Chemistry (2021)

Article

Reply to: Binding site for MDL-801 on SIRT6

Zhimin Huang, Junxing Zhao, Wei Deng, Yingyi Chen, Jialin Shang… in Nature Chemical Biology (2021)

Article

Evaluation of a cell model expressing βKlotho for screening FGF21 analogues

βKlotho as the major role is a necessary auxiliary protein when fibroblast growth factor 21 (FGF21) binds FGF21 receptors (FGFR) for activating intracellular signaling pathways that ultimately generate biologi...

**aochen Guo, **angxiang Wang, Qingyan Yuan, Chao Wu, Hongmei Gao… in Cytotechnology (2019)

Article

Identification of a cellularly active SIRT6 allosteric activator

SIRT6, a member of the SIRT deacetylase family, is responsible for deacetylation of histone H3 N^ε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac). As a tumor suppressor, SIRT6 has frequently been found to have low exp...

Zhimin Huang, Junxing Zhao, Wei Deng, Yingyi Chen, Jialin Shang… in Nature Chemical Biology (2018)

Article

A novel strategy for production of ethanol and recovery of xylose from simulated corncob hydrolysate

To develop a xylose-nonutilizing Escherichia coli strain for ethanol production and xylose recovery.

**feng Sun, Jie Wang, Kangming Tian, Zixing Dong, **aoguang Liu… in Biotechnology Letters (2018)

Article

AntCaller: an accurate variant caller incorporating ancient DNA damage

Ancient DNA obtained from ancient samples, such as sediments, bones, and teeth, is an important genetic resource that can be used to reconstruct an evolutional history of humans, animals, and plants. The appli...

Boyan Zhou, Shaoqing Wen, Lingxiang Wang, Li **, Hui Li… in Molecular Genetics and Genomics (2017)

Article

Production of a therapeutic protein by fusing it with two fragments of the carboxyl-terminal peptide of human chorionic gonadotropin β-subunit in Pichia pastoris

To produce a therapeutic protein (endostatin) by fusion with two fragments of the carboxyl-terminal peptide (CTP) of the human chorionic gonadotropin β-subunit in Pichia pastoris.

Baolong Wang, **n Wang, Chris Wayne, **angxiang Wang, Lei Han… in Biotechnology Letters (2016)