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Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation

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  1. Article

    Open Access

    Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice

    Glutathione synthetase (GSS) catalyzes the final step in the synthesis of glutathione (GSH), a well-established antioxidant. Research on the specific roles of the Gss gene during spermatogenesis remains limited d...

    Haixia Zhu, Yin Cheng, **anmei Wang, **ng Yang, Min Liu, Jun Liu… in Cell Death & Disease (2023)

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  2. Article

    Open Access

    MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma

    The efficacy of immune checkpoint blockade (ICB) therapy depends on sufficient infiltration and activation of primed tumor-specific cytotoxic T lymphocytes (CTLs) in the tumor microenvironment. However, many t...

    Kuo Jiang, Qianfeng Zhang, Yong Fan, Jia Li, Jitao Zhang… in Cell Death Discovery (2022)

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  3. Article

    Open Access

    Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells

    The sonic hedgehog (Shh) pathway is highly activated in a variety of malignancies and plays important roles in tumorigenesis, tumor growth, drug resistance, and metastasis. Our recent study showed that the inh...

    Sumei Li, **gxiang Wang, Yurong Lu, Yuqing Zhao, Richard A. Prinz… in Cell Death & Disease (2021)

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  4. Article

    Open Access

    Combined inhibition of JAK1/2 and DNMT1 by newly identified small-molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells

    Despite substantial advances in treating cervical cancer (CC) with surgery, radiation and chemotherapy, patients with advanced CC still have poor prognosis and significantly variable clinical outcomes due to t...

    Shiqi She, Yang Zhao, Bo Kang, Cheng Chen, **nyu Chen… in Cell Death & Disease (2020)

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  5. Article

    Open Access

    PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma

    High-grade serous ovarian carcinoma (HGSOC) is the most lethal type of gynecologic malignancy. Chemoresistance is the main reason for the poor prognosis of HGSOC. PDZ-binding kinase (PBK) promotes the malignan...

    Hanlin Ma, Yingwei Li, **angxiang Wang, Huan Wu, Gonghua Qi… in Cell Death & Disease (2019)

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  6. Article

    Reprogrammed mouse astrocytes retain a “memory” of tissue origin and possess more tendencies for neuronal differentiation than reprogrammed mouse embryonic fibroblasts

    Direct reprogramming of a variety of somatic cells with the transcription factors Oct4 (also called Pou5f1), Sox2 with either Klf4 and Myc or Lin28 and Nanog generates the induced pluripotent stem cells (iPSCs...

    Changhai Tian, Yongxiang Wang, Lijun Sun, Kangmu Ma, Jialin C. Zheng in Protein & Cell (2011)

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