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Open AccessExpert Consensus on the Clinical Utilization of Ketamine and Its Isomers in Intensive Care Units
Analgesia and sedation are important treatment strategies in the intensive care unit (ICU). Due to the opioid crisis, opioid-sparing medications become the focus of clinical studies. Ketamine and its isomers (...
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Article
Open AccessSepsis-Associated Acute Kidney Injury
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The kidneys are one of the first organs to be injured in sepsis. About two-thirds of patients...
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Article
Open AccessFLAIR vascular hyperintensity combined with asymmetrical prominent veins in acute anterior circulation ischemic stroke: prediction of collateral circulation and clinical outcome
To investigate the value of fluid-attenuated inversion recovery vascular hyperintensity (FVH) within asymmetrical prominent veins sign (APVS) on susceptibility-weighted imaging predicting collateral circulatio...
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Article
Open AccessIntestinal Microbiota in Sepsis
Sepsis is defined as a life-threatening organ dysfunction, which is caused by a dysregulated host response to infection. The composition of the intestinal microbiota is significantly different between patients...
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Article
Open AccessClinical outcomes and safety of polymyxin B in the treatment of carbapenem-resistant Gram-negative bacterial infections: a real-world multicenter study
High morbidity and mortality due to carbapenem-resistant Gram-negative bacilli (CR-GNB) has led to the resurgence of polymyxin B (PMB) use in the last decade. The aim of our multicenter, real-world study was t...
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Article
Open AccessSARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection
The long-term immunity and functional recovery after SARS-CoV-2 infection have implications in preventive measures and patient quality of life. Here we analyzed a prospective cohort of 121 recovered COVID-19 p...
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Article
Open AccessMesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application
Sepsis is a life-threatening organ dysfunction caused by a deregulated host response to infection, and is the most common cause of death in the intensive care unit. Although the pathogenesis of sepsis has made...
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Article
Correction to: B7-H3 modulates endothelial cell angiogenesis through the VEGF cytokine
The order of authors’ affiliations in the published version of this article was not consistent with the order in the submitted manuscript due to typesetting
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Open AccessADJunctive Ulinastatin in Sepsis Treatment in China (ADJUST study): study protocol for a randomized controlled trial
Sepsis is a major challenge in critical care and is associated with high mortality. Current management of sepsis and septic shock remains mainly supportive. Both basic and clinical research has shown that ulin...
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Article
Open AccessAssociation between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review
Mesothelin is a membrane-bound glycoprotein. Although the biologic function of mesothelin is not very clear, researchers have found that it plays a role in the survival, proliferation, and migration of tumor c...
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Prevalence of prehypertension and hypertension in a Chinese rural area from 1991 to 2007
Shandong Province is located in the east of China. The province is characterized by robust economic development, with a rural population accounting for 56% of the total population. However, no data are availab...