-
Article
Open AccessJARID2, a novel regulatory factor, promotes cell proliferation, migration, and invasion in oral squamous cell carcinoma
Accurate regulation of gene expression is crucial for normal development and function of cells. The prognostic significance and potential carcinogenic mechanisms of the related gene JARID2 in OSCC are not yet ...
-
Article
Open AccessThe Implication of Diabetes-Specialized Nurses in Aiming for the Better Treatment and Management of Patients with Diabetes Mellitus: A Brief Narrative Review
Diabetes mellitus (DM) is regarded as one of the most critical public health challenges of the 21st century. It has evolved into a burgeoning epidemic since the last century, and today ranks among the major ca...
-
Article
Open AccessPolycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma
The polycomb group (PcG) comprises a set of proteins that exert epigenetic regulatory effects and play crucial roles in diverse biological processes, ranging from pluripotency and development to carcinogenesis...
-
Article
Open AccessPrognostic model revealing pyroptosis-related signatures in oral squamous cell carcinoma based on bioinformatics analysis
One of the most common oral carcinomas is oral squamous cell carcinoma (OSCC), bringing a heavy burden to global health. Although progresses have been made in the intervention of OSCC, 5 years survival of pati...
-
Article
Open AccessMechanical-electrical-chemical coupling study on the stabilization of a hafnia-based ferroelectric phase
The metastable polar orthorhombic phase is believed to be the origin of the ferroelectricity of hafnia-based films. The adjustment of stain, oxygen vacancies and dopant during film deposition and the wake-up e...
-
Article
Development and deep-sea exploration of the Haidou-1
-
Article
Open AccessCACA guidelines for ultrasound hyperthermia for oral and maxillofacial head and neck squamous cell carcinoma
Most of the patients with oral and maxillofacial malignancy are in the middle and advanced stages at diagnosis and the incidence rate is increasing in recent years. Chemotherapy alone is difficult to benefit t...
-
Article
Open AccessTreatment of the New Era: Long-Term Ticagrelor Monotherapy for the Treatment of Patients with Type 2 Diabetes Mellitus following Percutaneous Coronary Intervention: A Meta-analysis
Type 2 diabetes mellitus (T2DM) is a risk factor for the development of coronary artery disease (CAD). In patients with acute coronary syndrome (ACS), guidelines recommend a potent P2Y12 inhibitor in addition ...
-
Article
Open AccessIdentification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis
Oral submucous fibrosis (OSF) is a chronic and insidious oral potentially malignant disorder associated with a 4–17% risk of oral squamous cell carcinoma (OSCC). Our previous study found that proteasomal activ...
-
Article
The thermal conductivity and tolerance factor modulated ferroelectric thermal stability of Ba0.955La0.03TiO3 relaxor ferroelectric
Based on the design from the view of the Goldschmidt tolerance factor, Ba0.955La0.03TiO3-doped Zr ferroelectric ceramics were prepared by solid-state reaction method. The experimental results show that our hypoth...
-
Article
Open AccessExpert consensus on the clinical application of recombinant adenovirus human p53 for head and neck cancers
The first gene therapy product, recombinant adenovirus human p53 (rAd-p53), has been approved by CFDA since 2013. During these years, most of the clinical trials and the relevant basic research were carried out b...
-
Article
Open AccessThe Therapeutic Effects of Mild to Moderate Intensity Aerobic Exercise on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Trials
It has been recommended that physical activity be a part of treatment and management regimens of type 2 diabetes mellitus (T2DM), and research has shown that regular physical exercise facilitates glycemic cont...
-
Article
Open AccessResistive switching and optical properties of strontium ferrate titanate thin film prepared via chemical solution deposition
The polycrystalline strontium ferrate titanate (SrFe0.1Ti0.9O3, SFTO) thin films have been successfully prepared by chemical solution method. By analyzing the current-voltage (I–V) characteristics, we discuss the...
-
Article
Oxygen defect related high temperature dielectric relaxation behavior in (Ba,La)(Zr,Sn,Ti)O3 ceramics
Ferroelectric materials with the typical perovskite structure are widely used in capacitors, ultrasonic devices, oil drilling, transducers, and other fields. Lead-lanthanum-zirconium-titanate ceramics co-doped...
-
Article
The defect related energy-storage properties of A-site off-stoichiometry ferroelectric ceramic
The Ba0.985La0.015Ti0.9Sn0.1O3 ceramic has been prepared by a cost-effective solid-state reaction method. Preliminary room-temperature X-ray diffraction indicates that the crystallization of the ceramic is good. ...
-
Article
Open AccessTherapeutic potential of small extracellular vesicles derived from lipoma tissue in adipose tissue regeneration—an in vitro and in vivo study
To explore the adipogenic effects of the small extracellular vesicles derived from the lipoma tissues (sEV-LT), and to find a new cell-free therapeutic approach for adipose tissue regeneration.
-
Article
Open AccessCardiovascular Outcomes Post Percutaneous Coronary Intervention in Patients with Obstructive Sleep Apnea and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Type 2 diabetes mellitus (T2DM) is a major risk factor for the occurrence of cardiovascular diseases. Similar to T2DM, obstructive sleep apnea (OSA) is also known to be a risk factor for cardiovascular disease...
-
Article
Effect of Heating Mode on Thermal Stability of Nanocrystalline Hydroxyapatite
This study reports the effect of heating mode on the thermal stability of nanocrystalline hydroxyapatite (HA) by comparing conventional electric resistance heating and microwave heating of HA to 1100°C under t...
-
Article
The repertoire of tumor-infiltrating lymphocytes within the microenvironment of oral squamous cell carcinoma reveals immune dysfunction
The role of tumor-infiltrating lymphocytes (TILs) in the immune remodeling of tumor microenvironments (TME) in oral squamous cell carcinoma (OSCC) remains controversial. In this study, we pursued a comprehensi...
-
Article
Metal-organic frameworks nanoswitch: Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference
Endo/lysosomal escape and gene release are two critical bottlenecks in gene delivery. Herein, a novel photo-controllable metal-organic frameworks (MOFs) nanoswitch is rationally designed for enhancing small in...
