5 Result(s)
within
**ngrui Zhang
Human Genetics
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Article
Open AccessClinical and genetic characteristics of Chinese patients with congenital cranial dysinnervation disorders
Congenital cranial dysinnervation disorders (CCDDs) are a group of diseases with high clinical and genetic heterogeneity. Clinical examinations combined with Magnetic resonance imaging (MRI) and whole exome se...
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Article
Open AccessFinding an easy way to harmonize: a review of advances in clinical research and combination strategies of EZH2 inhibitors
Enhancer of zeste homolog 2 inhibitors (EZH2i) have garnered increased attention owing to their anticancer activity by targeting EZH2, a well-known cancer-promoting factor. However, some lymphomas are resistan...
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Article
Open AccessSymphony of epigenetic and metabolic regulation—interaction between the histone methyltransferase EZH2 and metabolism of tumor
Increasing evidence has suggested that epigenetic and metabolic alterations in cancer cells are highly intertwined. As the master epigenetic regulator, enhancer of zeste homolog 2 (EZH2) suppresses gene transc...
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Article
A Simple and Convenient Sticky/Blunt-End Ligation Method for Fusion Gene Construction
Here we present a simple and convenient sticky/blunt-end ligation method for fusion gene construction. The fusion gene is constructed by seamless ligation of 5′-end phosphorylated blunt ends instead of by over...
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Article
Cloning and characterization of a novel gene which encodes a protein interacting with the mitosis-associated kinase-like protein NTKL
NTKL is an evolutionarily conserved kinase-like protein. The cell-cycle-dependent centrosomal localization of NTKL suggested that it was involved in centrosome-related cellular function. The mouse NTKL protein...
