-
Article
Open AccessA Predictive Model for Graft Failure in Femtosecond Laser-Assisted Penetrating Keratoplasty Among Chinese Patients: A 2-Year Study
Graft failure is a major challenge in femtosecond laser-assisted penetrating keratoplasty (Fs-PKP). This study focuses on the development and validation of a clinical predictive model aimed at identifying the ...
-
Article
Open AccessEnhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4
Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective properties. However, the poor water solubility of OBB hinders its release and absorption thus resulting in low bioavailabil...
-
Article
Open AccessAssociation between the composite dietary antioxidant index and metabolic dysfunction-associated steatotic liver disease in adults: a cross-sectional study from NHANES 2017–2020
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a predominant liver disease worldwide, lacking approved drugs for clinical intervention at present. The composite dietary antioxi...
-
Article
Open AccessALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration
N6-methyladenosine (m6A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral disc degeneration (IDD), a common cause of low back pain, remains unclear.
-
Article
Computational discovery of fast interstitial oxygen conductors
New highly oxygen-active materials may enhance many energy-related technologies by enabling efficient oxygen-ion transport at lower temperatures, for example, below ~400 °C. Interstitial oxygen conductors have...
-
Article
Open AccessBilateral optic nerve infiltration and leukemic retinopathy as initial signs of leukemia relapse with central nervous system involvement in an adult: a case report
We describe a case in which bilateral optic nerve infiltration and leukemic retinopathy were the initial signs of disease relapse in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia...
-
Article
Open AccessSqualene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB
While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood.
-
Article
Open AccessDual-ROS-scavenging and dual-lingering nanozyme-based eye drops alleviate dry eye disease
Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing the development of dry eye disease (DED). The currently avail...
-
Article
Open AccessTemporal shifts in 24 notifiable infectious diseases in China before and during the COVID-19 pandemic
The coronavirus disease 2019 (COVID-19) pandemic, along with the implementation of public health and social measures (PHSMs), have markedly reshaped infectious disease transmission dynamics. We analysed the im...
-
Article
L-domains as locally continuous sequent calculi
Inspired by a framework of multi lingual sequent calculus, we introduce a formal logical system called locally continuous sequent calculus to represent L-domains. By considering the logic states defined on locall...
-
Article
Feature aggregation and modulation network for single image dehazing
Deep learning-based methods have recently achieved satisfying results in image dehazing. However, we observe that various researchers devote themselves to learning haze-free images directly, while often paying...
-
Article
Open AccessTwo putative calcium-dependent protein kinases are involved in the regulation of sugarcane defense genes
Sugarcane is a primary sugar crop and an important source of bioenergy. Pathogens are the major factors affecting sugarcane yield and sugar content. However, the mechanisms of sugarcane defense regulation rema...
-
Article
Open AccessMODELS: a six-step framework for develo** an infectious disease model
Since the COVID-19 pandemic began, a plethora of modeling studies related to COVID-19 have been released. While some models stand out due to their innovative approaches, others are flawed in their methodology....
-
Article
Open AccessA distal enhancer guides the negative selection of toxic glycoalkaloids during tomato domestication
Steroidal glycoalkaloids (SGAs) are major plant defense metabolites against pests, while they are considered poisonous in food. The genetic basis that guides negative selection of SGAs production during tomato...
-
Article
Epidemiological characteristics and factors influencing hospitalization burden among trauma patients: a retrospective analysis
This investigation aimed to understand the epidemiological characteristics and hospitalization burden and its possible influencing factors of patients with different injury mechanisms.
-
Article
Going Deeper into Recognizing Actions in Dark Environments: A Comprehensive Benchmark Study
While action recognition (AR) has gained large improvements with the introduction of large-scale video datasets and the development of deep neural networks, AR models robust to challenging environments in real...
-
Article
PCS-granularity weighted ensemble clustering via Co-association matrix
Ensemble clustering has attracted much attention for its robustness and effectiveness compared to single clustering. As one of the representative methods, most co-association matrix-based ensemble clustering t...
-
Article
Solution to two problems on ideally conjunctive join-semilattices
In this paper, we solve two problems concerning the ideally conjunctive join-semilattices. First, we show that $$L/R^1({{\,\textrm{Id}\,}}L)|_...
-
Article
Open AccessDual-Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease
A dual-atom nanozyme (DAN) was successfully prepared based on Fe and Mn bimetallic single-atom embedded in N-doped carbon material and modified with hydrophilic polymer.
... -
Article
A broad-angle spectrum reflection pump–probe technique based on the Brewster angle
Here, a sensitive reflection pump–probe technique is demonstrated for studying the optical nonlinear (NLO) properties of samples with a high linear absorptive coefficient at a certain wavelength. Light with a ...
