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Open AccessLeveraging logical definitions and lexical features to detect missing IS-A relations in biomedical terminologies
Biomedical terminologies play a vital role in managing biomedical data. Missing IS-A relations in a biomedical terminology could be detrimental to its downstream usages. In this paper, we investigate an approa...
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Open AccessThe activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial
Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) protein significantly improve survival in patients with advanced non-small-cell lung cancer (NSCLC), but its impact on early-stage grou...
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Article
Open AccessMap** of Alzheimer’s disease related data elements and the NIH Common Data Elements
Alzheimer’s Disease (AD) is a devastating disease that destroys memory and other cognitive functions. There has been an increasing research effort to prevent and treat AD. In the US, two major data sharing res...
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Open AccessIdentification of gene variation feature for targeted therapy of non-small cell lung cancer through combined method of DNA and RNA sequencing
Next generation sequencing (NGS) is typically used to reveal tumor gene variation feature for targeted therapy of various types of human cancers, including non-small cell lung cancer (NSCLC). Here, we report t...
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Open AccessIntegrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge ...
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Open AccessProvenance differentiation and earth surface process of the Mu Us sandy land constrained by detrital zircon U–Pb dating
Understanding the provenance and sediment surface processes of the Mu Us sandy land (MU) is critical for comprehending aeolian deposits and dust transportation in inland Asia and the Chinese Loess Plateau (CLP...
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Open AccessmRNA-LNP vaccination-based immunotherapy augments CD8+ T cell responses against HPV-positive oropharyngeal cancer
Although mRNA vaccines are known as potent activators of antigen-specific immune responses against infectious diseases, limited understanding of how they drive the functional commitment of CD8+ T cells in tumor m...
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Open AccessPredictive model for persistent hypertension after surgical intervention of primary aldosteronism
Primary aldosteronism (PA) is one of the most common causes of secondary hypertension and is potentially curable. However, a large number of patients still undergo persistent hypertension (PHT) after unilatera...
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Open AccessMachine learning molecular dynamics simulation identifying weakly negative effect of polyanion rotation on Li-ion migration
Understanding the physical picture of Li ion transport in the current ionic conductors is quite essential to further develop lithium superionic conductors for solid-state batteries. The traditional practice of...
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The phenotype and prediction of long-term physical, mental and cognitive COVID-19 sequelae 20 months after recovery, a community-based cohort study in China
Long-term sequelae clustering phenotypes are important for precise health care management in COVID-19 survivors. We reported findings for 1000 survivors 20 months after diagnosis of COVID-19 in a community-bas...
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Open AccessCorrection: Construction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing
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Open AccessThe transaction behavior of cryptocurrency and electricity consumption
Rapidly increasing cryptocurrency prices have encouraged cryptocurrency miners to participate in cryptocurrency production, increasing network hashrates and electricity consumption. Growth in network hashrates...
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Open AccessConstruction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing
As the direct organ of villus, hair follicles have obvious seasonal cycles. The hair follicle cycle is orchestrated by multiple cell types that together direct cell renewal and differentiation. But the regulat...
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Open AccessCytokines secreted from adipose tissues mediate tumor proliferation and metastasis in triple negative breast cancer
Obesity is a high-risk factor for development and poor prognosis of triple-negative breast cancer (TNBC), which was considered as a high malignant and poor clinical outcome breast cancer subtype. TNBC prolifer...
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Correction to: Early Prediction of Malignant Edema After Successful Recanalization in Patients with Acute Ischemic Stroke
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Open AccessMulti-omics analysis dissects the genetic architecture of seed coat content in Brassica napus
Brassica napus is an important vegetable oil source worldwide. Seed coat content is a complex quantitative trait that negatively correlates with the seed oil content in B. napus.
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Open AccessFrom desert to monsoon: irreversible climatic transition at ~ 36 Ma in southeastern Tibetan Plateau
Although there is increasing evidence for wet, monsoonal conditions in Southeast Asia during the late Eocene, it has not been clear when this environment became established. Cenozoic sedimentary sequences cons...
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Environmental governance and innovation: an overview
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Open AccessIdentification of missing concepts in biomedical terminologies using sequence-based formal concept analysis
As biomedical knowledge is rapidly evolving, concept enrichment of biomedical terminologies is an active research area involving automatic identification of missing or new concepts. Previously, we prototyped a...
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Open AccessRelationship between tectonism and desertification inferred from provenance and lithofacies changes in the Cenozoic terrestrial sequence of the southwestern Tarim Basin
The modern-day Tarim Basin is covered almost entirely by the Taklimakan sand desert and is one of the most arid regions in the world. Unraveling the aridification history of the desert is important for underst...
