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Article
mRNA vaccine technology for infectious diseases and beyond
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Article
Open AccessImmunological profile of lactylation-related genes in Crohn’s disease: a comprehensive analysis based on bulk and single-cell RNA sequencing data
Crohn's disease (CD) is a disease characterized by intestinal immune dysfunction, often accompanied by metabolic abnormalities. Disturbances in lactate metabolism have been found in the intestine of patients w...
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Article
Identifying priorities under highly heterogeneous environments through species distribution models to facilitate orchid conservation
The ecological suitability prediction and analysis of specific taxonomic groups at finer geographic scales provide vital references for identifying and prioritizing biodiversity hotspots, especially for uneven...
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Article
RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death
Regulatory T (Treg) cells play an essential role in maintaining immune balance across various physiological and pathological conditions. However, the mechanisms underlying Treg homeostasis remain incompletely und...
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Article
Diffusion and structural MRI as potential biomarkers in people with Parkinson’s disease and cognitive impairment
To explore the neuroimage change in Parkinson’s disease (PD) patients with cognitive impairments, this study investigated the correlation between plasma biomarkers and morphological brain changes in patients w...
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Article
Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity
Monkeypox was declared a global health emergency by the World Health Organization, and as of March 2023, 86,000 confirmed cases and 111 deaths across 110 countries have been reported. Its causal agent, monkeyp...
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Article
Open AccessRevealing effective regional decarbonisation measures to limit global temperature increase in uncertain transition scenarios with machine learning techniques
Climate change mitigation scenarios generated by integrated assessment models have been extensively used to support climate change negotiations on the global stage. To date, most studies exploring ensembles of...
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Article
Open AccessDeepEdit: single-molecule detection and phasing of A-to-I RNA editing events using nanopore direct RNA sequencing
Single-molecule detection and phasing of A-to-I RNA editing events remain an unresolved problem. Long-read and PCR-free nanopore native RNA sequencing offers a great opportunity for direct RNA editing detectio...
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Article
cPKCγ Inhibits Caspase-9-Initiated Neuronal Apoptosis in an Ischemia Reperfusion Model In Vitro Through p38 MAPK-p90RSK-Bad Pathway
Strokes are one of the leading causes of death and disability in the world. Previously we have found that conventional protein kinase Cγ (cPKCγ) plays neuroprotective role in ischemic strokes. Further, we foun...
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Chapter and Conference Paper
The Influence of New Media on Consumers in the Information Age
The abstract should summarize the contents of the paper in short terms, i.e. Since the twenty-first century, the rise of new media, for hundreds of years has been to newspapers, broadcasting, and other ways to...
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Article
Open AccessSingle-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications
Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5+ DM) is an autoimmune condition associated with rapidly progressive interstitial lung disease and high mortality. The aetiology and p...
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Article
Abnormal low-field M-type magnetoresistance in hexagonal noncollinear ferromagnetic MnFeGe alloy
The new magnetic degree of freedom provided by the noncollinear structure plays an important role in the development of spintronic devices. In this work, we conducted a systematic study on the magnetic and ele...
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Article
Spatial-temporal dynamics of alpine grassland coverage and its response to climate warming in Mt. Qomolangma Nature Preserve during 2000–2019
The Qinghai–Tibet Plateau (QTP) has the largest and highest alpine grassland ecosystem in the world, which is considered to be the most sensitive and vulnerable ecosystem to climate change. Its dynamic changes...
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Article
Analytical modelling of the mechanical damage of soil induced by lightning strikes capturing electro-thermal, thermo-osmotic, and electro-osmotic effects
This article presents a mathematical model for simulating the mechanical behaviour of lightning strikes and analysing the resulting damage to the soil. This article focuses on the electro-thermal effect and se...
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Article
Open AccessLong-term high-risk drinking does not change effective doses of propofol for successful insertion of gastroscope in Chinese male patients
Available literature indicates that long-term drinkers demand a higher dose of propofol for induction of anesthesia than non-drinkers. However, there is no study having assessed the influence of long-term high...
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Article
Open AccessDirect investigation of the reorientational dynamics of A-site cations in 2D organic-inorganic hybrid perovskite by solid-state NMR
Limited methods are available for investigating the reorientational dynamics of A-site cations in two-dimensional organic–inorganic hybrid perovskites (2D OIHPs), which play a pivotal role in determining their...
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Article
Open AccessDENA: training an authentic neural network model using Nanopore sequencing data of Arabidopsis transcripts for detection and quantification of N6-methyladenosine on RNA
Models developed using Nanopore direct RNA sequencing data from in vitro synthetic RNA with all adenosine replaced by N6-methyladenosine (m6A) are likely distorted due to superimposed signals from saturated m6A r...
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Article
A new technique for high-fidelity cutting technology for hydrate samples
Designing a high-fidelity cutting device is one of the difficulties in hydrate samples pressure-holding transfer. Due to the limitations of the existing mechanical system, there is much damage to the cut surfa...
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Article
Open AccessRapid screening and identification of viral pathogens in metagenomic data
Virus screening and viral genome reconstruction are urgent and crucial for the rapid identification of viral pathogens, i.e., tracing the source and understanding the pathogenesis when a viral outbreak occurs....
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Article
Open AccessElectrically controlled spin polarized current in Dirac semimetals
We propose a highly tunable \(100\%\) 100 % ...
