492 Result(s)
within
**ng Long
Biomedicine, general
Medicine/Public Health, general
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Article
Open AccessEvaluation of safety and efficacy of gefitinib ('iressa', zd1839) as monotherapy in a series of Chinese patients with advanced non-small-cell lung cancer: experience from a compassionate-use programme
The gefitinib compassionate-use programme has enabled >39,000 patients worldwide to receive gefitinib ('Iressa', ZD1839) treatment. This paper reports the outcome of gefitinib treatment in Chinese patients who...
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Open AccessRecruitment of young women to a trial of chlamydia screening – as easy as it sounds?
Recruiting to trials is complex and difficult. The Prevention of Pelvic Infection (POPI) trial aims to see if screening women for chlamydia and treating those found to be infected reduces the incidence of pelv...
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Open AccessCoexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer
Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2...
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Open AccessCollagen density promotes mammary tumor initiation and progression
Mammographically dense breast tissue is one of the greatest risk factors for develo** breast carcinoma. Despite the strong clinical correlation, breast density has not been causally linked to tumorigenesis, ...
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Open AccessProteomic analysis of differential proteins in pancreatic carcinomas: Effects of MBD1 knock-down by stable RNA interference
Methyl-CpG binding domain protein 1 (MBD1), a suppressor of gene transcription, may be involved in inactivation of tumor suppressor genes during tumorigenesis. Over-expression of MBD1 has been reported in huma...
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Open AccessExpression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways
The oncoprotein HER-2 is over-expressed and/or has undergone gene amplification in between 20 to 30% of breast and ovarian cancers. HER-2 amplified breast cancer is associated with a poor prognosis and increas...
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Open AccessIdentification of a novel CHEK2variant and assessment of its contribution to the risk of breast cancer in French Canadian women
BRCA1 and BRCA2 account for the majority of the known familial breast cancer risk, however, the impact of other cancer susceptibility genes largely remains to be elucidated. Checkpoint Kinase 2 (CHEK2) is an imp...
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Open AccessIn silico analysis and verification of S100 gene expression in gastric cancer
The S100 protein family comprises 22 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. They were involved in the regulation of a number of cellular processes such as cell cycle pr...
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Open AccessClinical significance of Neutrophil gelatinase-associated lipocalin(NGAL) expression in primary rectal cancer
Emerging evidence has demonstrated that Neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in multiple malignancies, including oesophagus cancer, and plays a critical role in tumorigenesis and p...
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Open AccessThe -271 G>A polymorphism of kinase insert domain-containing receptor gene regulates its transcription level in patients with non-small cell lung cancer
Kinase insert domain-containing receptor (KDR) plays a critical role in the metastasis of cancer and is used as a molecular target in cancer therapy. We investigated the characteristics of the -271 G>A polymor...
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Open AccessDeoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells
The progression from Barrett's metaplasia to adenocarcinoma is associated with the acquirement of an apoptosis-resistant phenotype. The bile acid deoxycholate (DCA) has been proposed to play an important role ...
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Open AccessClinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancy
Colorectal cancer (CRC) is one of the leading causes of malignant death worldwide. Because young age of onset is often considered a poor prognostic factor for CRC, it is important to identify the poor outcomes...
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Open AccessXPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk
Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of hepatocellular carcinoma (HCC) related to the exposure of aflatoxin B1 ...
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Open AccessPluripotency-associated genes in human nasopharyngeal carcinoma CNE-2 cells are reactivated by a unique epigenetic sub-microenvironment
There is increasing evidence that cancers contain their own stem-like cells, and particular attention has been paid to one subset of cancer-stem cells termed side population (SP). Stem cells under normal physi...
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Open AccessCD133 expression in chemo-resistant Ewing sarcoma cells
Some human cancers demonstrate cellular hierarchies in which tumor-initiating cancer stem cells generate progeny cells with reduced tumorigenic potential. This cancer stem cell population is proposed to be a s...
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Open AccessEffect of probe characteristics on the subtractive hybridization efficiency of human genomic DNA
The detection sensitivity of low abundance pathogenic species by polymerase chain reaction (PCR) can be significantly enhanced by removing host nucleic acids. This selective removal can be performed using a ma...
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Open AccessInhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin
Angiogenesis plays an important role in the development and progression of tumors. Kallistatin exerts anti-angiogenic and anti-inflammatory activities that may be effective in inhibiting tumor metastasis. We i...
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Open AccessDifferential expression of centrosomal proteins at different stages of human glioma
High-grade gliomas have poor prognosis, requiring aggressive treatment. The aim of this study is to explore mitotic and centrosomal dysregulation in gliomas, which may provide novel targets for treatment.
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Open AccessClinicopathologic characteristics and prognostic factors of ovarian fibrosarcoma: the results of a multi-center retrospective study
Ovarian fibrosarcomas are very rare tumors, and therefore, few case studies have evaluated the prognostic factors of this disease. To our knowledge, this study represents the largest study to evaluate the clin...
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Open AccessEastern asian expert panel opinion: designing clinical trials of molecular targeted therapy for hepatocellular carcinoma
The largest burden of hepatocellular carcinoma (HCC) lies in Asia, secondary to hepatitis B virus (HBV) infection. Improved survival with sorafenib has fostered new research but many challenges remain in desig...
