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Article
Open AccessThe effect of exercise rehabilitation with exergames combined with ice therapy in the treatment of obese patients with gout: protocol for a clinical trial
Gout remains a leading cause of inflammatory arthritis worldwide, and the main risk factor for gout is persistent hyperuricemia. The clinical management of gout is mostly drug-based, and other treatment option...
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Article
Application Analysis of Multiple Neurons Connected with Fast Inhibitory Synapses
Almost all living organisms exhibit autonomic oscillatory activities, which are primarily generated by the rhythmic activities of their neural systems. Several nonlinear oscillator models have been proposed to...
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Article
Nearly Time-Optimal Kernelization Algorithms for the Line-Cover Problem with Big Data
Based on well-known complexity theory conjectures, any polynomial-time kernelization algorithm for the NP-hard Line-Cover problem produces a kernel of size ...
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Article
Continuous-flow synthesis of 7-methoxy-1-tetralone: an important intermediate of (-)-Dezocine
Continuous flow technology has been widely adopted in manufacturing active pharmaceutical ingredients (APIs). Herein, we report an expeditious multi-step continuous-flow strategy for an efficient and highly p...
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Article
Open AccessCorrection: Effect of guselkumab on serum biomarkers in patients with active psoriatic arthritis and inadequate response to tumor necrosis factor inhibitors: results from the COSMOS phase 3b study
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Open AccessEffect of guselkumab on serum biomarkers in patients with active psoriatic arthritis and inadequate response to tumor necrosis factor inhibitors: results from the COSMOS phase 3b study
Guselkumab is a selective interleukin (IL)-23 inhibitor targeting the IL-23p19 subunit. In the phase 3b COSMOS trial, guselkumab demonstrated efficacy in treating participants with active psoriatic arthritis (...
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Article
Open AccessClinical outcome analysis of modified B-Lynch sutures in the fundus uteri and part of the corpus uteri for the prevention of intraoperative haemorrhage during caesarean delivery in women with twin pregnancy: a retrospective study
To explore the efficacy of modified B-Lynch sutures in the fundus uteri and part of the corpus uteri for the prevention of intraoperative haemorrhage during caesarean delivery in women with twin pregnancy.
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Article
Open AccessMaxillary anterior segmental distraction osteogenesis to correct maxillary hypoplasia and dental crowding in cleft palate patients: a preliminary study
The aim of this study was to present comprehensive skeletal, dental and facial aesthetic outcomes and long-term stability of maxillary anterior segmental distraction osteogenesis (MASDO) for the treatment of m...
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Open AccessGenetic and Molecular Distinctions Between Axial Psoriatic Arthritis and Radiographic Axial Spondyloarthritis: Post Hoc Analyses from Four Phase 3 Clinical Trials
Emerging evidence suggests psoriatic arthritis (PsA) with axial involvement (axPsA) and radiographic axial spondyloarthritis (r-axSpA) may possibly represent distinct disorders, with some differing clinical ma...
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Article
Textual emotion recognition method based on ALBERT-BiLSTM model and SVM-NB classification
Textual emotion recognition is an increasingly popular research area, which recognizes human emotions by capturing textual information posted by people, and the recognition results depend on the composition of...
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Article
TfOH-catalyzed three-component synthesis of Dithiocarbamates from α-Diazoesters under continuous flow conditions
The synthesis of dithiocarbamates derivatives is important for their practical utilization as pharmaceuticals and for other purposes. Herein, we demonstrated the TfOH-catalyzed synthesis of dithiocarbamates vi...
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Article
Open AccessClinical outcome analysis of intramural myoma greater than 8 cm in diameter removed during caesarean section: a retrospective study
To explore the safety and efficiency of endometrial myomectomy (EM) and Serosal myomectomy (SM) for the removal of intramural myoma greater than 8 cm in diameter during cesarean section.
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Open AccessAdditive-controlled asymmetric iodocyclization enables enantioselective access to both α- and β-nucleosides
β-Nucleosides and their analogs are dominant clinically-used antiviral and antitumor drugs. α-Nucleosides, the anomers of β-nucleosides, exist in nature and have significant potential as drugs or drug carriers...
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Article
Enhancement production of lipid and unsaturation of fatty acids in Cryptococcus humicola via addition of calcium ion
Lipids synthesized by oleaginous yeasts are considered to be the best candidates for biodiesel production. Cryptococcus humicola as an oleaginous yeast accumulated lipid in cells. In order to optimize the conditi...
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Article
Continuous-flow synthesis of N,N′-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexanediamine (DTMPA) in a Micro fixed-bed reactor
An expeditious and efficient continuous-flow process is reported for the synthesis of N,N′-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexanediamine (DTMPA). The starting material 1,6-hexanediamine (HMDA) mixes...
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Article
Cognitive population initialization for swarm intelligence and evolutionary computing
Cognitive computing has been commonly used to address different forms of optimization issues. Swarm intelligence (SI) and evolutionary computing (EC) are population-based intelligent stochastic search techniqu...
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Article
Open AccessIncidence and risk factors for suicidal ideation in a sample of Chinese patients with mixed cancer types
Suicidal ideation (SI) is often overlooked as a risk factor for people with cancer. Because it is often a precursor for suicidal behavior, it is critical to identify and address SI in a timely manner. This stu...
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Article
A Refined Branching Algorithm for the Maximum Satisfiability Problem
The Maximum satisfiability problem (MaxSAT) is a fundamental NP-hard problem which has significant applications in many areas. Based on refined observations, we derive a branching algorithm of running time ...
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Article
Open AccessThe clinical evaluation of IIA balloon occlusion in caesarean delivery for patients with PAS: a retrospective study
The aim of this study is the clinical evaluation of IIA balloon occlusion in the caesarean delivery in patients with a diagnosis of placenta accreta spectrum.
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Article
Open AccessAltered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease
Abnormalities in brain glucose metabolism and accumulation of abnormal protein deposits called plaques and tangles are neuropathological hallmarks of Alzheimer’s disease (AD), but their relationship to disease...
