4,902 Result(s)

Article

Correction to: Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes

Yingjiao Liu, Shifeng Chu, Yaomei Hu, Songwei Yang… in Cellular and Molecular Neurobiology (2024)

Article

Benmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial

Immunochemotherapy is the first-line standard for extensive-stage small-cell lung cancer (ES-SCLC). Combining the regimen with anti-angiogenesis may improve efficacy. ETER701 was a multicenter, double-blind, r...

Ying Cheng, Jianhua Chen, Wei Zhang, Chao **e, Qun Hu, Ningning Zhou… in Nature Medicine (2024)

Article

Author Correction: LINE-1 transcription activates long-range gene expression

**ufeng Li, Luyao Bie, Yang Wang, Yaqiang Hong, Ziqiang Zhou, Yiming Fan… in Nature Genetics (2024)

Article

Nicotinamide riboside restores nicotinamide adenine dinucleotide levels and alleviates brain injury by inhibiting oxidative stress and neuroinflammation in a mouse model of intracerebral hemorrhage

Hemorrhagic stroke is a global health problem owing to its high morbidity and mortality rates. Nicotinamide riboside is an important precursor of nicotinamide adenine dinucleotide characterized by a high bioav...

**g She, Hua Zhang, Hui Xu, Yan-Yan Li, Jun-Chao Wu, Rong Han… in Molecular Neurobiology (2024)

Article

Systematic Mendelian Randomization Exploring Druggable Genes for Hemorrhagic Strokes

Patients with hemorrhagic stroke have high rates of morbidity and mortality, and drugs for prevention are very limited. Mendelian randomization (MR) analysis can increase the success rate of drug development b...

Lun-Zhe Yang, Yong Yang, Chuan Hong, Qi-Zhe Wu, **ong-Jie Shi… in Molecular Neurobiology (2024)

Article

Fitness costs of Tn1546-type transposons harboring the vanA operon by plasmid type and structural diversity in Enterococcus faecium

This study analyzed the genetic traits and fitness costs of vancomycin-resistant Enterococcus faecium (VREfm) blood isolates carrying Tn1546-type transposons harboring the vanA operon.

Dokyun Kim, Da Young Kang, Min Hyuk Choi… in Annals of Clinical Microbiology and Antimi… (2024)

Article

Development and validation of machine learning models to predict MDRO colonization or infection on ICU admission by using electronic health record data

Multidrug-resistant organisms (MDRO) pose a significant threat to public health. Intensive Care Units (ICU), characterized by the extensive use of antimicrobial agents and a high prevalence of bacterial resist...

Yun Li, Yuan Cao, Min Wang, Lu Wang, Yiqi Wu… in Antimicrobial Resistance & Infection Contr… (2024)

Article

Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastoma

Recent studies have highlighted the significant role of the NF-κB signaling pathway in the initiation and progression of cancer. Furthermore, long noncoding RNAs (lncRNAs) have been identified as pivotal regul...

Feng **ao, Hong Zhu, Yun Guo… in Journal of Experimental & Clinical Cancer … (2024)

Article

Urinary microbiome dysbiosis is associated with an inflammatory environment and perturbed fatty acids metabolism in the pathogenesis of bladder cancer

Bladder cancer is a common malignancy with high recurrence rate. Early diagnosis and recurrence surveillance are pivotal to patients’ outcomes, which require novel minimal-invasive diagnostic tools. The urinar...

Cen Wu, **aoyu Wei, Zhiyang Huang, Zhixiong Zheng… in Journal of Translational Medicine (2024)

Article

Saturation genome editing of BAP1 functionally classifies somatic and germline variants

Many variants that we inherit from our parents or acquire de novo or somatically are rare, limiting the precision with which we can associate them with disease. We performed exhaustive saturation genome editin...

Andrew J. Waters, Timothy Brendler-Spaeth, Danielle Smith… in Nature Genetics (2024)

Article

Radiology of fibrosis part III: genitourinary system

Fibrosis is a pathological process involving the abnormal deposition of connective tissue, resulting from improper tissue repair in response to sustained injury caused by hypoxia, infection, or physical damage...

Sofia Maria Tarchi, Mary Salvatore… in Journal of Translational Medicine (2024)

Article

Radiology of fibrosis part II: abdominal organs

Fibrosis is the aberrant process of connective tissue deposition from abnormal tissue repair in response to sustained tissue injury caused by hypoxia, infection, or physical damage. It can affect almost all or...

Sofia Maria Tarchi, Mary Salvatore… in Journal of Translational Medicine (2024)

Article

Radiology of fibrosis. Part I: Thoracic organs

Sustained injury from factors such as hypoxia, infection, or physical damage may provoke improper tissue repair and the anomalous deposition of connective tissue that causes fibrosis. This phenomenon may take ...

Sofia Maria Tarchi, Mary Salvatore… in Journal of Translational Medicine (2024)

Article

Correction: Rotenone Could Activate Microglia Through NFκB Associated Pathway

Yu-he Yuan, Jian-dong Sun, Miao-miao Wu, **-feng Hu… in Neurochemical Research (2024)

Article

Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia

Angiotensin II (AngII) induces the contraction and proliferation of vascular smooth muscle cells (VSMCs). AngII activates phospholipase C-β (PLC-β), thereby inducing Ca²⁺ mobilization as well as the production of...

Seo Yeon **, Jung Min Ha, Hye ** Kum, Ji Soo Ma… in Experimental & Molecular Medicine (2024)

Article

Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue

The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining testicular characteristics and spermatogenesis. Conventional 2D and t...

Se-Ra Park, Myung Geun Kook, Soo-Rim Kim, Choon-Mi Lee… in Experimental & Molecular Medicine (2024)

Article

Author Correction: Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers

Wenzhi Tan, Jayalakshmi Thiruppathi, Seol Hee Hong, Sao Puth, Sophea Pheng… in npj Vaccines (2024)

Article

Long noncoding RNA TMPO-AS1 upregulates BCAT1 expression to promote cell proliferation in nasopharyngeal carcinoma via microRNA let-7c-5p

Long non-coding RNA (lncRNA) is a group of RNA transcripts that contribute to tumor development by post-transcriptionally regulating cancer-related genes. Nasopharyngeal carcinoma (NPC) is an epithelial tumor ...

Huan Wang, Fuming Zhou, Jia Wan, Hong Yu, ** Wang in Genes and Environment (2024)

Article

USP38 exacerbates pressure overload-induced left ventricular electrical remodeling

Ubiquitin-specific protease 38 (USP38), belonging to the USP family, is recognized for its role in controlling protein degradation and diverse biological processes. Ventricular arrhythmias (VAs) following hear...

Yucheng Pan, Zheng **ao, Hongjie Yang, Bin Kong, Hong Meng, Wei Shuai… in Molecular Medicine (2024)

Article

Correction: Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2L914F mutation in endothelial cells

Bojana Lazovic, Hoang-Tuan Nguyen, Mohammadhassan Ansarizadeh, Leif Wigge… in Angiogenesis (2024)