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Article
A real-world study of tyrosine kinase inhibitors plus anti-PD-1 immunotherapy with or without chemoembolization for hepatocellular carcinoma patients with main portal vein invasion
Although systemic therapies are recommended for hepatocellular carcinoma (HCC) patients with main portal vein (MPV) invasion and preserved liver function, the outcome is limited. In the real-world, chemoembolizat...
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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
Open AccessNon-Abelian braiding of Fibonacci anyons with a superconducting processor
Quantum many-body systems with a non-Abelian topological order can host anyonic quasiparticles. It has been proposed that anyons could be used to encode and manipulate information in a topologically protected ...
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Article
Open AccessEntanglement and pseudo entanglement dynamics versus fusion in CFT
The fusion rules and operator product expansion (OPE) serve as crucial tools in the study of operator algebras within conformal field theory (CFT). Building upon the vision of using entanglement to explore the...
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Article
A New Discovery of Mineralization as Subseafloor Hydrothermal Replacement in the Duddar Super-Large SEDEX Lead-Zinc Deposit in Pakistan
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Article
Application of UiO-66 and its composites for remediation and resource recovery of typical environmental contaminants: a review
UiO-66 series metal–organic framework materials (MOFs) are typical porous materials assembled by Zr4+ with a large mass-to-nucleus ratio and terephthalic acid ligands, which form tetrahedral and octahedral cages ...
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Article
The magmatic origin of propylitic alteration of the Zhengguang epithermal Au-Zn deposit, Heilongjiang, China: evidence from mineral compositions and H–O-Sr isotopes
The origin of propylitic fluids in intermediate sulfidation mineralization has not been investigated in detail. Here, we present an extensive petrographic, geochemical, and isotopic (O-H-Sr) study of propyliti...
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Article
Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity
The CRISPR system is an adaptive immune system found in prokaryotes that defends host cells against the invasion of foreign DNA1. As part of the ongoing struggle between phages and the bacterial immune system, th...
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Article
Innovative coaxial high-temperature thin-film sensor with core–shell structure surpassing traditional multilayer films
High-temperature thin-film sensors (TFSs) often suffer from inadequate tolerance to elevated temperatures. In this study, an innovative approach is presented to fabricate in situ integrated TFSs with a core–sh...
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Article
Meshing characteristic analysis of spur gear pair with tooth surface wear fault based on improved fractal method
The three-dimensional (3D) fractal contact model of the interaction between gear teeth is established considering the actual surface morphology of gear teeth. The time-varying meshing stiffness (TVMS) model of...
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Article
Grain size effect on plastic microformation behavior for Inconel 718 foils: Experiment and modeling
With the rapid development of the aerospace industry, there is an increasing demand for miniaturized parts made of Inconel 718 foils. However, the grain size effect on the plastic deformation behavior of thin ...
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Article
Reaction mechanism between Al2O3–MgO refractory materials and rare earth high-carbon heavy rail steel
Submerged entry nozzle (SEN) clogging is a major problem affecting the production quality of rare earth steel, and finding a suitable refractory outlet can significantly reduce production costs. To explore the...
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Article
Metabolic engineering of Corynebacterium glutamicum for the efficient production of β-Alanine from glucose
β-Alanine is the only naturally occurring β-type amino acid, with various applications in the pharmaceutical, food, and chemical industries. Given the growing market demand, the study of β-alanine production i...
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Article
Mammalian PIWI–piRNA–target complexes reveal features for broad and efficient target silencing
The PIWI-interacting RNA (piRNA) pathway is an adaptive defense system wherein piRNAs guide PIWI family Argonaute proteins to recognize and silence ever-evolving selfish genetic elements and ensure genome inte...
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Article
Open AccessPerovskite Oxides Toward Oxygen Evolution Reaction: Intellectual Design Strategies, Properties and Perspectives
Develo** electrochemical energy storage and conversion devices (e.g., water splitting, regenerative fuel cells and rechargeable metal-air batteries) driven by intermittent renewable energy sources holds a gr...
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Article
Prevalence of thalassemia-carrier couples and fertility risk assessment
Thalassemia is a highly prevalent hematologic disease in Guizhou, China. This study aimed to determine the epidemiological characteristics of thalassemia in couples at childbearing age and assess the neonatal ...
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Article
Open AccessExplainable machine learning for early predicting treatment failure risk among patients with TB-diabetes comorbidity
The present study aims to assess the treatment outcome of patients with diabetes and tuberculosis (TB-DM) at an early stage using machine learning (ML) based on electronic medical records (EMRs). A total of 42...
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Article
Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Article
Open AccessNanobiolubricant grinding: a comprehensive review
Minimum quantity lubrication (MQL), which considers the cost, sustainability, flexibility, and quality, has been actively explored by scholars. Nanoadditive phases have been widely investigated as atomizing me...
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Article
Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy: A Multicenter Double-Blind Randomized Controlled Trial
To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction (TW) in treating patients with diabetic peripheral neuropathy (DPN).
