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Article
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1
The development of targeted chemotherapeutic agents against colorectal cancer (CRC), one of the most common cancers with a high mortality rate, is in a constant need. Nannocystins are a family of myxobacterial...
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Article
Open AccessMultiplexing near- and far-field functionalities with high-efficiency bi-channel metasurfaces
Propagating waves and surface waves are two distinct types of light-transporting modes, the free control of which are both highly desired in integration photonics. However, previously realized devices are bulk...
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Article
Prospective observational study on biomarkers of response in pancreatic ductal adenocarcinoma
Adjuvant chemotherapy benefits patients with resected pancreatic ductal adenocarcinoma (PDAC), but the compromised physical state of post-operative patients can hinder compliance. Biomarkers that identify cand...
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Article
Open AccessMolecular basis of Spns2-facilitated sphingosine-1-phosphate transport
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Article
Accelerating the design of pili-enabled living materials using an integrative technological workflow
Bacteria can be programmed to create engineered living materials (ELMs) with self-healing and evolvable functionalities. However, further development of ELMs is greatly hampered by the lack of engineerable non...
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Article
Olfactory Three-Needle Electroacupuncture Improved Synaptic Plasticity and Gut Microbiota of SAMP8 Mice by Stimulating Olfactory Nerve
To investigate the effects and mechanisms of olfactory three-needle (OTN) electroacupuncture (EA) stimulation of the olfactory system on cognitive dysfunction, synaptic plasticity, and the gut microbiota in se...
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Article
Open AccessID1 expressing macrophages support cancer cell stemness and limit CD8+ T cell infiltration in colorectal cancer
Elimination of cancer stem cells (CSCs) and reinvigoration of antitumor immunity remain unmet challenges for cancer therapy. Tumor-associated macrophages (TAMs) constitute the prominant population of immune ce...
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Article
Open AccessEvidence for the decays B0 → \( \overline{D} \) (*)0ϕ and updated measurements of the branching fractions of the \( {B}_s^0 \) → \( \overline{D} \) (*)0ϕ decays
Evidence for the decays B0 → D ¯ ...
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Article
Open AccessRBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
N6-methyladenosine (m6A) methylation can be deposited on chromatin-associated RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state and transcription. However, the mechanism by whic...
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Article
Enabling technology and core theory of synthetic biology
Synthetic biology provides a new paradigm for life science research (“build to learn”) and opens the future journey of biotechnology (“build to use”). Here, we discuss advances of various principles and techno...
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Article
Clinical, Microbiological, and Molecular Characterization of Candia (Starmera) stellimalicola, a Rare Fungal Pathogen Causing Human Infections
Candia (Starmera) stellimalicola is a yeast species spread worldwide and recovered from varieties of ecological reservoirs, but human infections are rarely reported. In this study, we reported an intra-abdominal ...
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Article
Open Access\({{J}/\psi }\) and \({{D}} ^0\) production in \(\sqrt{s_{\scriptscriptstyle \text {NN}}} =68.5\,\text {GeV} \) PbNe collisions
The first measurement of \({{J}/\psi }\) J / ψ
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Article
Open AccessAtypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration
Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to determine HCT after chronic liver injur...
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Article
Open AccessMeasurement of the ratio of branching fractions \( \mathcal{B}\left({B}_c^{+}\to {B}_s^0{\pi}^{+}\right)/\mathcal{B}\left({B}_c^{+}\to J/\psi {\pi}^{+}\right) \)
The ratio of branching fractions of B c + ...
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Article
Fuzzy adaptive event-triggered output feedback control of electro-hydraulic system
This article considers a fuzzy adaptive event-triggered control design problem for electro-hydraulic systems. The addressed electro-hydraulic system contains immeasurable states and unknown nonlinear dynamics....
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Article
Open AccessA study of \(C\!P\) violation in the decays \({{B} ^\pm } \rightarrow [{{K} ^+} {{K} ^-} {{\uppi } ^+} {{\uppi } ^-} ]_{D} h^{\pm }\) ( \(h = K, \pi \) ) and \({{B} ^\pm } \rightarrow [{{\uppi } ^+} {{\uppi } ^-} {{\uppi } ^+} {{\uppi } ^-} ]_{D} h^{\pm }\)
The first study of \(C\!P\) C P ...
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Article
Open AccessMeasurement of the \( {\Lambda}_c^{+} \) to D0 production ratio in peripheral PbPb collisions at \( \sqrt{s_{\textrm{NN}}} \) = 5.02 TeV
We report on a measurement of the Λ c + ...
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Article
Open AccessSearch for the lepton-flavour violating decays B0 → K*0μ±e∓ and \( {B}_s^0 \) → ϕμ±e∓
A search for the lepton-flavour violating decays B0 → K*0μ±e∓ and B s ...
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Article
Open AccessMeasurement of the top-quark mass using a leptonic invariant mass in pp collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
A measurement of the top-quark mass (mt) in the t t ¯ ...
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Article
Open AccessTMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor outcome and lacks of approved targeted therapy. Overexpression of epidermal growth factor receptor (EGFR) is found in more than 50% ...
