8 Result(s)
-
Article
Open AccessApplication and evaluation of the MLVA ty** assay for the Brucella abortus strains isolated in Korea
A Brucella eradication program has been executed in Korea. To effectively prevent and control brucellosis, a molecular method for genetic identification and epidemiological trace-back must be established. As p...
-
Article
Open AccessRecurrence-associated pathways in hepatitis B virus-positive hepatocellular carcinoma
Despite the recent identification of several prognostic gene signatures, the lack of common genes among experimental cohorts has posed a considerable challenge in uncovering the molecular basis underlying hepa...
-
Article
Open AccessTranscriptome analysis reveals the molecular mechanisms underlying growth superiority in a novel grouper hybrid (Epinephelus fuscogutatus♀ × E. lanceolatus♂)
Groupers (Epinephelus spp.) have been widely cultivated in China and South-East Asian countries. As a novel hybrid offspring crossed between E. fuscogutatus♀ and E. lanceolatus♂, Hulong grouper exhibits significa...
-
Article
Open AccessA TBX5 3′UTR variant increases the risk of congenital heart disease in the Han Chinese population
TBX5 is a vital transcription factor involved in cardiac development in a dosage-dependent manner. But little is known about the potential association of TBX5 3′ untranslated region (UTR) variations with congenit...
-
Article
Open AccessThe circular RNA circ-GRB10 participates in the molecular circuitry inhibiting human intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is the most common degenerative disease all over the word. Our previous study confirmed that the downregulated circ-GRB10 directly interacts with miR-328-5p, which modula...
-
Article
Open AccessHuman pluripotent stem cell-derived alveolar organoids for modeling pulmonary fibrosis and drug testing
Detailed understanding of the pathogenesis and development of effective therapies for pulmonary fibrosis (PF) have been hampered by lack of in vitro human models that recapitulate disease pathophysiology. In t...
-
Article
Open AccessOncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession
PKM2 is an important regulator of the aerobic glycolysis that plays a vital role in cancer cell metabolic reprogramming. In general, Trib2 is considered as a “pseudokinase”, contributing to different kinds of can...
-
Article
Open AccessExploring right ovary degeneration in duck and goose embryos by histology and transcriptome dynamics analysis
The development of asymmetric chick gonads involves separate developmental programs in the left and right gonads. In contrast to the left ovary develo** into a fully functional reproductive organ, the right ...
