11 Result(s)
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Article
Intravenous immunoglobulin for treatment of hospitalized COVID-19 patients: an evidence map** and meta-analysis
The clinical efficacy and safety of intravenous immunoglobulin (IVIg) treatment for COVID-19 remain controversial. This study aimed to map the current status and gaps of available evidence, and conduct a meta-...
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Article
Identification of CCL20 as a Key Biomarker of Inflammatory Responses in the Pathogenesis of Intracerebral Hemorrhage
Inflammatory responses after intracerebral hemorrhage (ICH) contribute to severe secondary brain injury, leading to poor clinical outcomes. However, the responsible genes for effective anti-inflammation treatm...
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Article
Open AccessPoricoic acid A suppresses renal fibroblast activation and interstitial fibrosis in UUO rats via upregulating Sirt3 and promoting β-catenin K49 deacetylation
Renal interstitial fibrosis is the common pathological process of various chronic kidney diseases to end-stage renal disease. Inhibition of fibroblast activation attenuates renal interstitial fibrosis. Our pre...
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Article
Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice
Epigallocatechin-3-gallate (EGCG) is a major polyphenol in green tea. In this study, we investigated the effects of EGCG on insulin resistance and insulin clearance in non-alcoholic fatty liver disease (NAFLD)...
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Article
N 1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
A series of N 1-{4-[(10S)-dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl) hydrazine derivatives 9a–9n possessing 4-quinolylhydrazone and artemisinin cores ...
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Article
Synthesis and biological activities of novel artemisinin derivatives as cysteine protease falcipain-2 inhibitors
A series of novel artemisinin derivatives were synthesized from artemisinin and different anilines. All compounds were obtained as β-isomers. The target compounds were evaluated for inhibition activity against Pl...
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Article
New chemical constituents from the rhizomes of Sparganium stoloniferum
A new sucrose ester named β-D-(1-O-acetyl-3-O-cis-feruloyl)fructofuranosyl α-D-2′,3′,6′-O-triacetylglucopyranoside 1 and a novel phenylpropanoid glycerol named 1-O-cis-feruloyl-3-O-trans-p-coumaroylglycerol 2, ha...
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Article
Establishment and characteristics of two syngeneic human osteosarcoma cell lines from primary tumor and skip metastases
To characterize and compare the different biological behaviors of 2 novel human osteosarcoma cell lines, Zos and Zos-M, established respectively from the primary tumor and the skip metastasis of an osteosarcom...
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Article
Comparative proteomic analysis of human osteosarcoma and SV40-immortalized normal osteoblastic cell lines
Comparative proteomics provide a powerful approach in screening for alterations in protein levels and post-translational modifications that are associated with tumors. In the present study, we aimed to identif...
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Article
Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines
To investigate the antiproliferative activity and apoptosis-inducing effects of bufalin on human osteosarcoma cell lines.
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Article
Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR
To investigate the reversal effects of curcumin on multidrug resistance (MDR) in a resistant human gastric carcinoma cell line.
