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Article
High-throughput fluorescence polarization method for identifying ligands of LOX-1
To develop and optimize a competitive fluorescence polarization (FP) method, and use it as a high-throughput screening (HTS) assay for drug discovery.
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Article
KATP Channel Openers Facilitate Glutamate Uptake by GluTs in Rat Primary Cultured Astrocytes
Increasing evidence, including from our laboratory, has revealed that opening of ATP sensitive potassium channels (KATP channels) plays the neuronal protective roles both in vivo and in vitro. Thus KATP channel o...
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Article
Open AccessCytoplasmic Kaiso is associated with poor prognosis in non-small cell lung cancer
Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involv...
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Article
p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity
It has been shown that oncoprotein p28GANK, which is consistently overexpressed in human hepatocellular carcinoma (HCC), plays a critical role in tumorigenesis of HCC. However, the underlying mechanism remains un...
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Article
Open AccessAxin downregulates TCF-4 transcription via β-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells
We previously reported that overexpression of Axin downregulates T cell factor-4 (TCF-4) transcription. However, the mechanism(s) by which Axin downregulates the transcription and expression of TCF-4 is not cl...
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Article
Open AccessComparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: A Systematic Review
Chronic viral hepatitis B remains a global public health concern. Currently, several drugs, such as tenofovir and adefovir, are recommended for treatment of patients with chronic hepatitis B. tenofovir is a nu...
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Article
Open AccessDown-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis
As a negative modulator of the canonical Wnt signaling pathway, Naked1 (NKD1) is widely expressed in many normal tissues. However, the expression pattern and clinicopathological significance of NKD1 in patient...
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Article
Open AccessTranscriptomic analysis of grape (Vitis viniferaL.) leaves during and after recovery from heat stress
Grapes are a major fruit crop around the world. Heat stress can significantly reduce grape yield and quality. Changes at the molecular level in response to heat stress and subsequent recovery are poorly unders...
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Article
Open AccessX-radiation inhibits histone deacetylase 1 and 2, upregulates Axin expression and induces apoptosis in non-small cell lung cancer
Histone deacetylase (HDAC) plays an important role in the deacetylation of histone, which can alter gene expression patterns and affect cell behavior associated with malignant transformation. The aims of this ...
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Article
Open AccessPulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall
Pulmonary sclerosing hemangioma (PSH) is an uncommon pulmonary tumor. Histologically, PSH typically consists of two types of cells, surface cuboidal cells and polygonal cells, four architectural patterns inclu...
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Article
Open AccessVariable Ki67 proliferative index in 65 cases of nodular fasciitis, compared with fibrosarcoma and fibromatosis
Nodular fasciitis is the most common pseudosarcomatous lesion of soft tissue. Ki67 was considered as a useful marker for distinguishing some benign and malignant lesions. To study the usefulness of Ki67 in dia...
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Article
Open AccessUse of immuno-dominant epitope derived from genotype 4 as a diagnostic reagent for detecting the antibodies against Hepatitis E Virus
Despite the genotype 4 has become the dominant cause of hepatitis E disease in China, none antigen derived from genotype 4 of hepatitis E virus (HEV) was used in current commercial anti-HEV immunoassay, and th...
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Article
Daptomycin exerts rapid bactericidal activity against Bacillus anthracis without disrupting membrane integrity
To examine whether the novel cyclic lipopeptide antibiotic daptomycin could be used to treat anthrax and to study the mechanisms underlying its bactericidal action against Bacillus anthracis.
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Article
Open AccessKir6.2-containing ATP-sensitive K+ channel is required for cardioprotection of resveratrol in mice
Resveratrol is a natural compound that affects energy metabolism and is also known to possess an array of cardioprotective effects. However, its overall effects on energy metabolism and the underlying mechanis...
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Article
Open AccessComposition and mode of occurrence of minerals in Late Permian coals from Zhenxiong County, northeastern Yunnan, China
Minerals in the Late Permian coals from the Niuchang-Yigu mining area, Zhenxiong County, northeastern Yunnan, China, were investigated using optical microscopy and low temperature ashing plus X-ray diffraction...
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Article
Open AccessPachytene piRNAs instruct massive mRNA elimination during late spermiogenesis
Spermatogenesis in mammals is characterized by two waves of piRNA expression: one corresponds to classic piRNAs responsible for silencing retrotransponsons and the second wave is predominantly derived from non...
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Article
USP11 regulates p53 stability by deubiquitinating p53
The p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to DNA repair, cell cycle arrest or apoptosis. The stability of p53 is essential for its tumor...
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Article
Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis
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Article
Aluminum extraction from coal ash by a two-step acid leaching method
To improve aluminum extraction efficiency, a two-step acid leaching process was proposed to dissolve aluminum and aluminum-bearing crystals with sulfuric acid. The first leaching residue (FLR) was obtained thr...
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Article
Open AccessSurgical treatment of lumbosacral tuberculosis by one-stage debridement and anterior instrumentation with allograft through an extraperitoneal anterior approach
This study was aimed to investigate the clinical outcome of lumbosacral tuberculosis treatment by one-stage radical debridement with bone allograft reconstruction and anterior instrumentation via a retroperito...
