4,556 Result(s)

Article

34^th ASMS Asilomar Conference on Quantitative Analysis of Posttranslational Modifications by Mass Spectrometry

Joseph A. Loo in Journal of The American Society for Mass Spectrometry (2019)

Article

1,4-Benzoquinone as a Highly Efficient Dopant for Enhanced Ionization and Detection of Nitramine Explosives on a Single-Quadrupole Mass Spectrometer Fitted with a Helium-Plasma Ionization (HePI) Source

Previous investigations have evaluated the efficacy of anions such as NO₃⁻, Cl⁻_, Br⁻, CH₃COO⁻, and CF₃COO⁻ as additives to generate or enhance mass spectrometric signals from explosives under plasma ionization co...

Julius Pavlov, David Douce, Steve Bajic… in Journal of The American Society for Mass S… (2019)

Article

Comparison of Clusters Produced from Sb₂Se₃ Homemade Polycrystalline Material, Thin Films, and Commercial Polycrystalline Bulk Using Laser Desorption Ionization with Time of Flight Quadrupole Ion Trap Mass Spectrometry

This study compared Sb₂Se₃ material in the form of commercial polycrystalline bulk, sputtered thin film, and homemade polycrystalline material using laser desorption ionization (LDI) time of flight mass spectrome...

Fei Huang, Lubomír Prokeš, Petr Němec… in Journal of The American Society for Mass S… (2019)

Article

Using LC-MS to Identify Clip** in Self-Assembled Nanoparticles During Vaccine Development

A hemagglutinin stabilized stem nanoparticle (HA-SS-np) that is designed to provide broad protection against influenza is being developed as a potential vaccine. During an early formulation screening study, re...

Nicole A. Schneck, Vera B. Ivleva… in Journal of The American Society for Mass S… (2019)

Article

Focus in Honor of Benjamin A. Garcia, Recipient of the 2018 ASMS Biemann Medal

Jenny Brodbelt in Journal of The American Society for Mass Spectrometry (2019)

Article

Ion-Neutral Collision Effects on Ion Trap** and Pseudopotential Depth in Ion Trap Mass Spectrometry

Ion trap** using radio-frequency (RF) devices has been widely used in mass spectrometry (MS). The pseudopotential well (PW) model enables the use of a pseudopotential depth, D, to evaluate the ion trap** capa...

Ming Li, **nwei Liu, **aoyu Zhou… in Journal of The American Society for Mass S… (2019)

Article

Compositional Analysis of Heavy Petroleum Distillates by Comprehensive Two-dimensional Gas Chromatography, Field Ionization and High-resolution Mass Spectrometry

We report recent progresses of combining comprehensive two-dimensional gas chromatography (2DGC or GC × GC) separation, field ionization (FI), and time-of-flight mass spectrometry (TOF MS) for the detailed ana...

Kuangnan Qian, Frank C. Wang in Journal of The American Society for Mass Spectrometry (2019)

Article

Ion Manipulation in Open Air Using 3D-Printed Electrodes

Ambient ionization techniques provide a way to sample materials via creation of ions in the air. However, transferring and focusing of these ions is typically done in the reduced pressure environment of the ma...

Kiran Iyer, Brett M. Marsh, Grace O. Capek… in Journal of The American Society for Mass S… (2019)

Article

Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes

Histone posttranslational modifications (PTMs) are essential for regulating chromatin and maintaining gene expression throughout cell differentiation. Despite the deep level of understanding of immunophenotypi...

Jeannie M. Camarillo, Suchitra Swaminathan… in Journal of The American Society for Mass S… (2019)

Article

Alkyl and aromatic nitrates in atmospheric particles determined by gas chromatography tandem mass spectrometry

Organic nitrates in the atmosphere are associated with photochemical pollution and are the main components of secondary organic aerosols, which are related to haze. An efficient method for determining organic ...

**nhao Yang, Feixian Luo, Junqi Li… in Journal of The American Society for Mass S… (2019)

Article

The Addition of Polar Organic Solvent Vapors During the Analysis of Proteins by DESI-MS

Exposure of electrospray droplets to organic vapors was shown to dramatically reduce alkali-metal adduction on protein ions and shift protein charge states. Since DESI-MS is affected by similar adduct species ...

Roshan Javanshad, Tara L. Maser… in Journal of The American Society for Mass S… (2019)

Article

A New Binary Matrix for Specific Detection of Mercury(II) Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry

The development of simple, low-cost, and specific detection method for mercury (Hg(II)) ions in aqueous media using matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) is a challenge due t...

Hani Nasser Abdelhamid, Hui-Fen Wu in Journal of The American Society for Mass Spectrometry (2019)

Article

Protonated Clusters of Neon and Krypton

We present a study of cationic and protonated clusters of neon and krypton. Recent studies using argon have shown that protonated rare gas clusters can have very different magic sizes than pure, cationic clust...

Michael Gatchell, Paul Martini… in Journal of The American Society for Mass S… (2019)

Article

A Decoupled Automation Platform for Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a biophysical technique well suited to the characterization of protein dynamics and protein–ligand interactions. In order to accurately define the rate...

Alfonso Espada, Ruben Haro, Jesus Castañon… in Journal of The American Society for Mass S… (2019)

Article

Identification and Quantitation of Linear Alkanes in Lubricant Base Oils by Using GC×GC/EI TOF Mass Spectrometry

Linear alkanes are a class of compounds known to negatively affect the physical performance of lubricant base oils. The ability to rapidly identify and quantify linear alkanes in lubricant base oils would enab...

Jeremy Manheim, Katherine Wehde… in Journal of The American Society for Mass S… (2019)

Article

Deep Intact Proteoform Characterization in Human Cell Lysate Using High-pH and Low-pH Reversed-Phase Liquid Chromatography

Post-translational modifications (PTMs) play critical roles in biological processes and have significant effects on the structures and dynamics of proteins. Top-down proteomics methods were developed for and a...

Dahang Yu, Zhe Wang, Kellye A. Cupp-Sutton… in Journal of The American Society for Mass S… (2019)

Article

Ion-Ion Interactions in Charge Detection Mass Spectrometry

Charge detection mass spectrometry (CDMS) is a single-particle technique where the masses of individual ions are determined by simultaneously measuring their mass-to-charge ratio (m/z) and charge. Ions are usuall...

Daniel Y. Botamanenko, Martin F. Jarrold in Journal of The American Society for Mass S… (2019)

Article

Fragmentation Spectra Prediction and DNA Adducts Structural Determination

In this work, chemical dynamics simulations were optimized and used to predict fragmentation mass spectra for DNA adduct structural determination. O⁶-methylguanine (O⁶-Me-G) was used as a simple model adduct to c...

Andrea Carrà, Veronica Macaluso… in Journal of The American Society for Mass S… (2019)

Article

Quantitation of Single and Combinatorial Histone Modifications by Integrated Chromatography of Bottom-up Peptides and Middle-down Polypeptide Tails

The analysis of histone post-translational modifications (PTMs) by mass spectrometry (MS) has been critical to the advancement of the field of epigenetics. The most sensitive and accurate workflow is similar t...

Kevin A. Janssen, Mariel Coradin… in Journal of The American Society for Mass S… (2019)

Article

High-Throughput Quantitative Top-Down Proteomics: Histone H4

Proteins physiologically exist as “proteoforms” that arise from one gene and acquire additional function by post-translational modifications (PTM). When multiple PTMs coexist on single protein molecules, top-d...

Matthew V. Holt, Tao Wang, Nicolas L. Young in Journal of The American Society for Mass S… (2019)