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  1. Article

    Open Access

    Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreER T2 ; Ihhfl/fl mice

    Previous observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (MMP-13) expression. However, ther...

    **gming Zhou, Qian Chen, Beate Lanske, Braden C Fleming… in Arthritis Research & Therapy (2014)

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  2. Article

    Erratum to: Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway

    Fangyuan Wei, Douglas C Moore, Lei Wei, Yanlin Li, Ge Zhang… in Arthritis Research & Therapy (2013)

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  3. Article

    Open Access

    Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway

    This study was performed to evaluate the attenuation of osteoarthritic (OA) pathogenesis via disruption of the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) signaling with AMD31...

    Fangyuan Wei, Douglas C Moore, Yanlin Li, Ge Zhang… in Arthritis Research & Therapy (2012)

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  4. No Access

    Article

    Apoptosis and rheumatoid arthritis: Past, present, and future directions

    The current studies of apoptosis in rheumatoid arthritis (RA) suggest that molecules (Fas-related or TNF-related), pathways (activation of pro-apoptosis or anti-apoptosis pathway), cell types (lymphocytes or s...

    John D. Mountz MS, PhD, Hui-Chen Hsu PhD… in Current Rheumatology Reports (2001)

  5. No Access

    Chapter

    Gene therapy for management of lupus: Correction of Fas and Fas ligand-induced apoptosis in murine disease — therapeutic rationale and strategies

    Identification of mutations of fas and fas ligand (fasL) in murine models of autoimmune disease have provided an important experimental tools for the analysis of tolerance and autoimmune disease. Mutations of fas...

    Huang-Ge Zhang, Martin Fleck, Hui-Chen Hsu… in Gene Therapy in Inflammatory Diseases (2000)

  6. No Access

    Chapter

    Apoptosis

    Apoptosis is a physiologic process that mediates the death of selected cells. In contrast to necrosis, which results from a strong nonspecific or toxic cell injury, apoptosis is initiated by ligand—receptor in...

    John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang… in Principles of Molecular Rheumatology (2000)