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  1. Article

    Open Access

    Recombinant human erythropoietin ameliorates cognitive dysfunction of APP/PS1 mice by attenuating neuron apoptosis via HSP90β

    Hua-Li Wan, Bing-Ge Zhang, Chongyang Chen… in Signal Transduction and Targeted Therapy (2022)

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  2. Article

    Open Access

    STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

    In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human t...

    **ao-Yue Hong, Hua-Li Wan, Ting Li… in Signal Transduction and Targeted Therapy (2020)

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  3. Article

    Open Access

    Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice

    In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that del...

    Xuekun Fu, Bo Zhou, Qinnan Yan, Chu Tao… in Signal Transduction and Targeted Therapy (2020)

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  4. No Access

    Article

    Regulation of apoptosis proteins in cancer cells by ubiquitin

    Ubiquitin inhibitors act at many levels to enhance apoptosis signaling. For TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis signaling, there are at least five mechanisms by which apoptosis are...

    Huang-Ge Zhang, Jianhua Wang, **nwen Yang, Hui-Chen Hsu, John D Mountz in Oncogene (2004)