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Article
Open AccessTargeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans
Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation of lipid contents and chronic inflammation. Traditional strategies primarily focus on lipid redu...
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Article
Open AccessLong-term prosthetic-associated subclinical thrombotic events evaluation by cardiac CTA after transcatheter aortic valve implantation: incidence and outcomes
To observe prosthetic-associated subclinical thrombotic events (PASTE) after transcatheter aortic valve implantation (TAVI) by cardiac CTA, and assess their impact on long-term patient outcomes.
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Article
Open AccessDevelopment and evaluation of rapid and accurate one-tube RPA-CRISPR-Cas12b-based detection of mcr-1 and tet(X4)
The emergence and quick spread of the plasmid-mediated tigecycline resistance gene tet(X4) and colistin resistance gene mcr-1 have posed a great threat to public health and raised global concerns. It is imperativ...
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Article
Effects of chrysanthemum extract on physicochemical, sensory, and in vitro digestion of set-type yogurt
Chrysanthemum (Chrysanthemum morifolium Ramat) contains multiple bioactive substances and presents health benefits. In this study, a chrysanthemum extract (CE) was prepared by heat reflux extraction method and a ...
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Article
Open AccessExploration of the influence of GOLGA8B on prostate cancer progression and the resistance of castration-resistant prostate cancer to cabazitaxel
Castration-resistant prostate cancer (CRPC) represents the final stage of prostate cancer (PCa). Cabazitaxel, a taxane chemotherapy drug, is used in treating CRPC. However, patients with CRPC eventually develo...
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Article
Open AccessReactor neutrino physics potentials of cryogenic pure-CsI crystal
This paper presents a world-leading scintillation light yield among inorganic crystals measured from a 0.5 kg pure-CsI detector operated at 77 Kelvin. Scintillation photons were detected by two 2-inch Hamamats...
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Article
O2 adsorption on Fe3O4 (110) surface and effect of gangue element Al do**: combined study of binding experiment and ab initio molecular dynamics
At high temperature, the chemical reaction mechanism at the interface of magnetite and the influence mechanism of gangue element Al on the oxidation performance of magnetite are not clear. In addition, due to ...
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Article
Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Article
Open AccessStudy of the Dynamic Failure Characteristics of Anisotropic Shales Under Impact Brazilian Splitting
The mechanical behaviors of shales with transversely isotropic characteristics under dynamic loading have great significance for structural instability in geotechnical engineering. To understand the effect of ...
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Article
Open AccessPRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling
Previous study showed that higher expression of prolactin (PRL) was found in CRPC samples compared with hormone-naive prostate cancer (HNPC) and benign prostatic hyperplasia (BPH) samples. We further investiga...
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Article
Open AccessIdentification of two novel large deletions in FBN1 gene by next-generation sequencing and multiplex ligation-dependent probe amplification
Mutations in fibrillin-1 (FBN1) are known to be associated with Marfan syndrome (MFS), an autosomal dominant connective tissue disorder. Most FBN1 mutations are missense or nonsense mutations. Traditional molecul...
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Article
Spatio-temporal Variation Characteristics of Extreme Climate Events and Their Teleconnections to Large-scale Ocean-atmospheric Circulation Patterns in Huaihe River Basin, China During 1959–2019
Huaihe River Basin (HRB) is located in China’s north-south climatic transition zone, which is very sensitive to global climate change. Based on the daily maximum temperature, minimum temperature, and precipita...
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Article
Groundwater Quality and Vulnerability Assessment in a Semiarid Karst Region of Northern China
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Article
Litter quality controls the contribution of microbial carbon to main microbial groups and soil organic carbon during its decomposition
A 163-day decomposition experiment with 13C-enriched leaf litter of Populus davidiana (low quality, with low N content, high C:N and high lignin content) and Quercus wutaishanica (high quality, with high N conten...
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Article
Effect of trimethylgallium flow rate on structural and photoelectronic properties of β-Ga2O3 films prepared by MOVPE
This study investigated the effect of trimethylgallium flow rate on the structural and photoelectronic properties of β-Ga2O3 films grown on α-Al2O3 (0001) substrates using MOVPE method. As the source flow rate gr...
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Article
Photobiomodulation Facilitates Rat Cutaneous Wound Healing by Promoting Epidermal Stem Cells and Hair Follicle Stem Cells Proliferation
Cutaneous wound healing represents a common fundamental phenomenon requiring the participation of cells of distinct types and a major concern for the public. Evidence has confirmed that photobiomodulation (PBM...
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Chapter and Conference Paper
Reliability Optimization Design Method for Firearms Automaton Mechanism
In order to deal with the reliability optimization design problem of mechanisms containing multiple motion phases and multiple collisions, this paper takes the firearms automaton as an example and gives a gene...
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Chapter and Conference Paper
Study on the Wide-Frequency Tuned Mass Damper Inhibiting Rail Corrugation and Noise in Floating Slab Track
In order to solve the rail corrugation in the curved section of the steel spring floating slab track in Qingdao metro, a new type wide-frequency tuned mass damper (WTMD) was developed, which integrated the lab...
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Article
Streamflow forecasting method with a hybrid physical process-mathematical statistic
The complex topology of river networks and the numerous factors influencing streamflow make it challenging to forecast streamflow in large river basins. Improving the accuracy of streamflow forecasting in thes...
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Article
Open AccessPreservation versus resection of Denonvilliers’ fascia in total mesorectal excision for male rectal cancer: follow-up analysis of the randomized PUF-01 trial
Traditional total mesorectal excision (TME) for rectal cancer requires partial resection of Denonvilliers’ fascia (DVF), which leads to injury of pelvic autonomic nerve and postoperative urogenital dysfunction...
