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  1. No Access

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    Enzymatic synthesis of deshexapeptide insulin

    The semisynthesis of deshexapeptide insulin (DHI) from desoctapeptide insulin (DOI) reported earlier1 showed that DHI was biologically active. However, the product was not quite homogeneous, mainly due to the est...

    Q. P. Cao, D. F. Cui, Y. S. Zhang in Nature (1981)

  2. No Access

    Article

    The **gaze ophiolite (Tibet): a peculiar oceanic lithosphere

    The **gaze ophiolite which outcrops along the Yarlung Zangbo river, southern Tibet, locally displays a complete ophiolitic sequence from marine sedimentary cover over basaltic volcanics to the north, to fresh ...

    A. Nicolas, J. Girardeau, J. Marcoux, B. Dupre, Wang **bin, Cao Yougong… in Nature (1981)

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    The Tibetan side of the India–Eurasia collision

    Results are reported from the 1980 joint French–Chinese field expedition in Tibet. The area covered was from the High Himalaya in the south, to the region of Nagqu ∼250 km north of Yangbajain. Ophiolites in th...

    P. Tapponnier, J. L. Mercier, F. Proust, J. Andrieux, R. Armijo, J. P. Bassoullet… in Nature (1981)

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    Article

    Intensity of the geomagnetic field near Loyang, China between 500 BC and AD 1900

    There are remarkably few data on the intensity of the geomagnetic field in early China. New results reported here indicate that the total intensity of the magnetic field of the Earth in the region near Loyang ...

    Q. Y. Wei, D. J. Li, G. Y. Cao, W. S. Zhang, S. P. Wang in Nature (1982)

  5. No Access

    Article

    Structure and evolution of the Himalaya–Tibet orogenic belt

    The 1981 French–Chinese expedition to Tibet focused on the Lhasa block, extending earlier coverage 400 km north of the Tsangpo suture. The Lhasa block stood between 10 and 15° N latitude over most of the Upper...

    C. J. Allégre, V. Courtillot, P. Tapponnier, A. Hirn, M. Mattauer, C. Coulon… in Nature (1984)

  6. No Access

    Article

    Strategy by which nitrogen-fixing unicellular cyanobacteria grow photoautotrophically

    Among nitrogen-fixing microorganisms, nitrogen-fixing cyanobacteria are unique in their ability to carry out oxygen-evolving photosynthesis and oxygen-labile nitrogen fixation within the same organisms1–3. These ...

    A. Mitsui, S. Kumazawa, A. Takahashi, H. Ikemoto, S. Cao, T. Arai in Nature (1986)

  7. No Access

    Article

    Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

    THE cellular protein p107 and the retinoblastoma protein (pRB) have many features in common. Most strikingly, they contain homologous protein domains that mediate interaction with the oncoproteins of several s...

    Liang Cao, Barbara Faha, Marlene Dembski, Li-Huei Tsai, Ed Harlow, Nicholas Dyson in Nature (1992)

  8. Article

    Rodent polyphyly?

    MASAMI HASEGAWA, YING CAO, JUN ADACHI, TAKA-AKI YANO in Nature (1992)

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  9. Article

    . . . and attacked

    FERNANDO AIUTI, CARLO BARONI, ANTONIO CAO, ANTONIO FANTONI in Nature (1992)

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  10. No Access

    Article

    Flexible light-emitting diodes made from soluble conducting polymers

    THE recent fabrication of light-emitting diodes (LEDs) from conjugated polymers1,2demonstrates the technological potential of this class of electronic materials. A variety of colours are possible, because the wav...

    G. Gustafsson, Y. Cao, G. M. Treacy, F. Klavetter, N. Colaneri, A. J. Heeger in Nature (1992)

  11. No Access

    Article

    Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

    The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These ET-1-/- homozygous mice die of respiratory failure at birth and have ...

    Yukiko Kurihara, Hiroki Kurihara, Hiroshi Suzuki, Tatsuhiko Kodama, Koji Maemura… in Nature (1994)

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    Article

    A matrix metalloproteinase expressed on the surface of invasive tumour cells

    GELATINASE A (type-IV collagenase; Mr 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as t...

    Hiroshi Sato, Takahisa Takino, Yasunori Okada, Jian Cao, Akira Shinagawa… in Nature (1994)

  13. No Access

    Article

    Partial activation of CD8+ T cells by a self-derived peptide

    T CELLS are normally activated when the peptide for which they are specific is presented to them in the context of the appropriate major histocompatibility complex (MHC) (class I and Class II for CD8+ and CD4+ T ...

    Wuxiong Cao, Scott S. Tykodi, Mark T. Esser, Vivian L. Braciale… in Nature (1995)

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    Article

    Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

    A PATHOLOGICALhallmark of Alzheimer's disease is the senile plaque, containing β-amyloid fibrils, microglia and astrocytes1. β-amyloid fibrils exert a cytotoxic effect on neurons2, and stimulate microglia to pro...

    Joseph El Khoury, Suzanne E. Hickman, Christian A. Thomas, Long Cao… in Nature (1996)

  15. Article

    HIV-1 subtype and second-receptor use

    Linqi Zhang, Yaoxing Huang, Tian He, Yunzhen Cao, David D. Ho in Nature (1996)

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    TRAF6 is a signal transducer for interleukin-1

    MANY cytokines signal through different cell-surface receptors to activate the transcription factor NF-κB (ref. 1). Members of the TRAF protein family have been implicated in the activation of NF-κB by the tu...

    Zhaodan Cao, Jessie **ong, Masahiro Takeuchi, Takeshi Kurama, David V. Goeddel in Nature (1996)

  17. No Access

    Article

    Clocking transient chemical changes by ultrafast electron diffraction

    With the advent of femtosecond (fs) time resolution in spectroscopic experiments, it is now possible to study the evolution of nuclear motions in chemical and photobiochemical reactions. In general, the react...

    J. Charles Williamson, Jianming Cao, Hyotcherl Ihee, Hans Frey, Ahmed H. Zewail in Nature (1997)

  18. No Access

    Article

    Decay characteristics of HIV-1-infected compartments during combination therapy

    Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1)1–3. The concentr...

    Alan S. Perelson, Paulina Essunger, Yunzhen Cao, Mika Vesanen, Arlene Hurley… in Nature (1997)

  19. No Access

    Article

    Primary afferent tachykinins are required to experience moderate to intense pain

    The excitatory neurotransmitter glutamate coexists with the peptide known as substance P in primary afferents that respond to painful stimulation1. Because blockers of glutamate receptors reliably reduce pain beh...

    Yu Qing Cao, Patrick W. Mantyh, Elaine J. Carlson, Anne-Marie Gillespie… in Nature (1998)

  20. No Access

    Article

    Dynamic responses of terrestrial ecosystem carbon cycling to global climate change

    Terrestrial ecosystems and the climate system are closely coupled, particularly by cycling of carbon between vegetation, soils and the atmosphere. It has been suggested1,2 that changes in climate and in atmospher...

    Mingkui Cao, F. Ian Woodward in Nature (1998)

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