27 Result(s)
within
**man Yu
Cardiology
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Article
Intersection Between Diabetes and Heart Failure: Is SGLT2i the “One Stone for Two Birds” Approach?
Diabetes mellitus (DM) is a major comorbidity of heart failure (HF). Comparing the similarities and differences in disease characteristics and treatment between the HF patients with and without DM, this review...
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Article
Changes of echocardiographic parameters in primary mitral regurgitation and determinants of symptom: an assessment from the Asian Valve Registry data
Clinicians often have a difficulty in determining the presence of mitral regurgitation (MR)-related symptoms because of subjectivity. However, there are few actual measurement data for echocardiographic left v...
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Article
Open AccessChallenges and opportunity in the era of quantitative echocardiography
The advancement of echocardiography in the past two decades is more than downsizing of the machines and improvement of image quality, but introduction of new imaging modalities leading to the ability of perfor...
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Chapter
Mechanical Circulatory Support in Transradial or Transbrachial Intervention for Acute Coronary Syndrome
Although transfemoral arterial approach (TFA) was the first developed method for coronary angiography and percutaneous coronary intervention (PCI), it has its own disadvantages, including the need for the bed ...
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Chapter
Endothelial Function in Myocardial Ischemia: Implications for Myocardial Protection
Development of therapeutic strategies to protect the heart against ischemia/reperfusion (I/R) injury is of great clinical importance. Due to the critical role of endothelial cells in myocardial I/R injury, vas...
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Article
Open AccessHow low should we target the LDL goal to improve survival for acute coronary syndrome patients in Hong Kong?
Utilization of lipid-lowering agents has been associated with improved long-term outcomes in acute coronary syndrome (ACS) patients. However, updated data regarding local use and outcomes was lacking.
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Article
Abnormal mitral–aortic intervalvular coupling in mitral valve diseases: a study using real-time three-dimensional transesophageal echocardiography
Mitral and aortic valves are coupled via fibrous tissue. This coupling is considered to be important for cardiac function before and after mitral valve surgery. The relationship between mitral–aortic coupling ...
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Article
Open AccessManagement of heart failure with preserved ejection fraction in a local public hospital in Hong Kong
Heart failure (HF) is one of the most debilitating chronic illnesses. The prevalence is expected to increase due to aging population. The current study aimed to examine the management of heart failure with pre...
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Article
Open AccessPhysicians’ Perception of the Patient Care Pathway for Acute Heart Failure in Asian Countries: Implications for Resource Allocation, Preventive Strategies and Clinical Trial Design
Heart failure (HF) is a growing epidemic in Asia. However, data are scarce regarding the patient care pathway of HF in Asia. We aimed to investigate the HF patient pathways in Asia using a questionnaire-based ...
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Chapter
Pacemaker Dependence After Atrioventricular Node Ablation
Atrial fibrillation is related to increased risk of stroke and heart failure and is a growing health issue with the aging of the world population. Rate control strategy for atrial fibrillation is not inferior ...
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Chapter
Cardiac Resynchronization Therapy: Do Benefits Justify the Costs and Are They Sustained Over the Long Term?
Heart failure is one of the commonest causes for hospitalization nowadays. Numerous trials demonstrated the beneficial effect of medical therapies including beta-blockers, angiotensin-converting enzyme inhibit...
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Article
Mechanistic Studies of AVE3085 Against Homocysteine in Endothelial Protection
Homocysteine (Hcy) is an independent risk factor for cardiovascular diseases that impairs endothelial function. We investigated whether the impaired endothelial function can be restored by the eNOS transcripti...
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Article
Mechanical antithrombotic intervention by LAA occlusion in atrial fibrillation
Oral anticoagulation, using apixaban, dabigatran, rivaroxaban, or warfarin is the first-line therapy for stroke prevention in patients with atrial fibrillation...
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Article
The need for multicentre cardiovascular clinical trials in Asia
In this opinion article, the authors discuss multicentre clinical trials in Asia. Asians have been under-represented in many clinical trials; differences in cardiovascular disease risk and drug responses betwe...
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Article
Bleeding of New Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials
Oral direct factor Xa inhibitors and oral direct thrombin inhibitors are new oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation (AF). We systematically reviewed their risk of major bleedi...
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Article
Ventricular resynchronization is the principle mechanism of benefit with cardiac resynchronization therapy
Although there is little debate over the fact that cardiac resynchronization therapy (CRT) can benefit the majority of patients selected with routine indications, the precise mechanism for improvement may be c...
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Article
AVE3085 Protects Coronary Endothelium from the Impairment of Asymmetric Dimethylarginine by Activation and Recoupling of eNOS
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of eNOS and it is recognized as a risk factor for endothelial dysfunction in cardiovascular diseases. We investigated the effect of AVE3085, a newly d...
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Chapter
Cardiac Resynchronization Therapy
Cardiac resynchronization therapy (CRT), or biventricular pacing therapy, is the first approved nonsurgical treatment of advanced heart failure (HF) employing implantable device. This therapy is characterized ...
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Article
Suppression of Collagen Production in Norepinephrine Stimulated Cardiac Fibroblasts Culture: Differential Effect of α and β-Adrenoreceptor Antagonism
Prolonged sympathetic activation is damaging to the heart and experimental norepinephrine (NE) infusion induces the deposition of myocardial collagen. This study investigated the effects of NE on collagen and ...
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Article
The cardiac MRI substudy to ongoing telmisartan alone and in combination with ramipril global endpoint trial/telmisartan randomized assessment study in ACE-intolerant subjects with cardiovascular disease: analysis protocol and baseline characteristics
The ONTARGET and TRANSCEND clinical trials were designed to investigate the cardioprotective effects of telmisartan 80 mg and ramipril 10 mg, alone and in combination, in patients at high risk of cardiovascula...
