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  1. No Access

    Article

    DNA methylation regulates bromodomain-containing protein 2 expression during adipocyte differentiation

    Obesity is characterized by excessive accumulation of white adipose tissue. Bromodomain-containing protein 2 (Brd2), which belongs to the bromodomain and extraterminal domain family of proteins, suppresses ad...

    Ruixin Sun, Yi Wu, Yuxiong Wang, Kun Zang… in Molecular and Cellular Biochemistry (2015)

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    Chapter

    Mutation of W457 Alters N-Hydroxy-L-Arginine Oxidation by Inducible no Synthase: A Single Turnover Study

    Nitric oxide synthases (NOS) are homodimeric enzymes which catalyze Arg to nitric oxide and citrulline (1). Its subunits contain a N-terminal oxygenase domain which can bind Fe-protoporphyrin IX (heme), Arg, and ...

    Zhi-Qiang Wang, Chin-Chuan Wei… in Chemistry and Biology of Pteridines and Fo… (2002)

  3. No Access

    Article

    TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase

    Transforming growth factor-β (TGF-β) and TGF-β-related factors induce apoptosis in a variety of tissues; however, the mechanism underlying this induction is largely unknown. Here, we demonstrate that TGF-β ind...

    Chuan-Wei Jang, Chun-Hau Chen, Chun-Chieh Chen, Jia-yun Chen… in Nature Cell Biology (2002)