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Article
Combining use of phillyrin and autophagy blocker exerts suppressive effect on nasopharyngeal carcinoma cell malignancy and autophagy via AMPK/mTOR/p70s6k signaling pathway
Nasopharyngeal carcinoma (NPC) is one of the malignant cancers in southern China. Phillyrin is a major active constituent extracted from Forsythia suspensa (Thunb.) and possesses anti-inflammatory and anti-tumor ...
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Article
GST-YOLO: a lightweight visual detection algorithm for underwater garbage detection
Underwater cleaning work primarily relies on human labor, but applying computer vision technology to Autonomous Underwater Vehicles can enhance cleaning efficiency. Considering that existing vision detection a...
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Article
Deep learning model to differentiate Crohn’s disease from intestinal tuberculosis using histopathological whole slide images from intestinal specimens
Crohn’s disease (CD) and intestinal tuberculosis (ITB) share similar histopathological characteristics, and differential diagnosis can be a dilemma for pathologists. This study aimed to apply deep learning (DL...
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Article
Information complexity of mixed-integer convex optimization
We investigate the information complexity of mixed-integer convex optimization under different types of oracles. We establish new lower bounds for the standard first-order oracle, improving upon the previous b...
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Article
Open AccessAstaxanthin-mediated Nrf2 activation ameliorates glucocorticoid-induced oxidative stress and mitochondrial dysfunction and impaired bone formation of glucocorticoid-induced osteonecrosis of the femoral head in rats
Osteonecrosis of the femoral head caused by glucocorticoids (GIONFH) is a significant issue resulting from prolonged or excessive clinical glucocorticoid use. Astaxanthin, an orange-red carotenoid present in m...
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Article
Liquid Phase Diffusion Analysis of WC–Co–Ni–Fe/HSS Composite Materials Based on DICTRA
Thermo-Calc and DICTRA software simulations were used to predict the feasibility of Co–Ni–Fe additives applied to WC/HSS composites, and WC–Co–Ni–Fe/HSS composites were prepared. The elemental diffusion behavi...
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Article
A Study on the Microstructural Evolution, Interfacial Diffusion and Mechanical Properties of Ultra-thin Stainless Steel–Copper Composites Fabricated by Roll Bonding
Systematic study on the microstructural evolution, interfacial diffusion and mechanical properties of ultra-thin stainless steel–copper composites (50 µm) after annealing treatment was conducted in the present...
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Article
Open AccessEvaluation of TikTok videos on acute pancreatitis: content quality and reliability analysis
Acute pancreatitis (AP) is a common acute digestive system disorder, with patients often turning to TikTok for AP-related information. However, the platform’s video quality on AP has not been thoroughly invest...
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Article
Comparative Study of the Microstructure and Mechanical Properties of WC/High-Speed Steel Composite Materials Prepared with Co, Ni, and Fe Binders
Three-mm-diameter WC/HSS composites with different binders (Co and Co-Ni-Fe) were prepared. The effect of two different binders on the microstructure and properties of WC powder and HSS composites was compared...
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Article
Analysis of the thermal expansion and mechanical properties of laser cladding of Invar alloy
Laser cladding has significant advantages in the forming process of Invar alloy. Nevertheless, the coefficient of thermal expansion, microstructure and mechanical properties still need to be further investigat...
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Article
Research on heat and mass transfer in the molten pool of laser cladding
In order to study the evolution laws of the temperature field, flow field, and macroscopic morphology of the molten pool during laser cladding process, this paper focuses on the changes in the morphology and f...
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Article
Open AccessImmunosuppressive microvesicles-mimetic derived from tolerant dendritic cells to target T-lymphocytes for inflammation diseases therapy
The utilization of extracellular vesicles (EV) in immunotherapy, aiming at suppressing peripheral immune cells responsible for inflammation, has demonstrated significant efficacy in treating various inflammato...
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Article
Open AccessAstaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p
As a natural extraction, astaxanthin is gaining increasing attention because of its safety and anti-tumor properties. It has been reported to participate in the progression of various types of cancer such as g...
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Article
In situ synthesis of oxygen-doped carbon quantum dots embedded in MIL-53(Fe) for efficient degradation of oxytetracycline
Introducing carbon quantum dots (CQDs) into photocatalysts is believed to boost the charge transfer rate and reduce charge complexation. Do** heteroatoms such as N, S, or P enable CQDs to have an uplifting e...
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Article
Overexpression of transcription factor FaMYB63 enhances salt tolerance by directly binding to the SOS1 promoter in Arabidopsis thaliana
Salinity is a pivotal abiotic stress factor with far-reaching consequences on global crop growth, yield, and quality and which includes strawberries. R2R3-MYB transcription factors encompass a range of roles i...
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Article
Open AccessMicroneedles loaded with cerium-manganese oxide nanoparticles for targeting macrophages in the treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is a prevalent inflammatory autoimmune disease characterised by persistent inflammation and joint damage with elevated levels of reactive oxygen species (ROS). Current treatment modal...
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Article
Dendrimer-induced synthesis of porous organosilica capsules for enzyme encapsulation
Organic matter-induced mineralization is a green and versatile method for synthesizing hybrid nanostructured materials, where the material properties are mainly influenced by the species of natural biomolecule...
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Article
Open AccessExploring the use of graphene lubricant and TiO2 nanolubricants in micro deep drawing of stainless steel SUS301
This study investigates the effects of different lubrication conditions on drawing force and microcup formation during micro deep drawing (MDD). Results show that graphene lubricant, in combination with TiO2 nano...
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Article
Open AccessResearch on knowledge graph-driven equipment fault diagnosis method for intelligent manufacturing
In the process of rotating machinery fault diagnosis (RMFD), the lack of feature conditions leads to the problem of low accuracy of traditional rule-based reasoning methods FD. This paper proposed a knowledge ...
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Article
Open AccessEffect of emerging digital technologies and methodologies combined with incentives on HbA1c in patients with type 2 diabetes mellitus: study protocol for a parallel, open randomized controlled trial
Type 2 diabetes mellitus (T2DM) is a common metabolic disease that requires long-term management and treatment. Digital intervention, as an emerging medical model, has been widely used in the treatment of T2DM...
