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Article
HDAC9 Deficiency Upregulates cGMP-dependent Kinase II to Mitigate Neuronal Apoptosis in Ischemic Stroke
Histone deacetylase 9 (HDAC9) is implicated in ischemic stroke by genome-wide association studies. We conducted a series of experiments using a mouse model of ischemic stroke (middle cerebral artery occlusion ...
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Article
Open AccessDiagnosis of membranous nephropathy with Anti-GBM glomerulonephritis: a case series report
The concomitant occurrence of membranous nephropathy and anti-glomerular basement (anti-GBM) disease has been previously described but is extremely rare. However, delayed recognition or misdiagnosis leads to d...
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Article
SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells
Background: Sorting nexin 14 (SNX14) is a member of the sorting junction protein family. Its specific roles in cancer development remain unclear. Therefore, in this study, we aimed to determine the effects and...
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Article
Open AccessFrom Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists
Datasets consist of measurement data and metadata. Metadata provides context, essential for understanding and (re-)using data. Various metadata standards exist for different methods, systems and contexts. Howe...
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Article
Open AccessIn silico analysis of the wild-type and mutant-type of BRCA2 gene
The aim of this study was to conduct an in silico analysis of a novel compound heterozygous variant in breast cancer susceptibility gene 2 (BRCA2) to clarify its structure–function relationship and elucidate t...
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Article
Open AccessSynergistic polarization engineering of dielectric towards low-voltage high-mobility solution-processed ultraflexible organic transistors
The emerging wearable skin-like electronics require the ultra-flexible organic transistor to operate at low voltage for electrical safety and energy efficiency and simultaneously enable high field-effect mobil...
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Article
Ferroelectric/semiconductor (BiFeO3–BaTiO3/AlN) lead-free ceramic composites featuring enhanced real-time d33 temperature stability
Although the BiFeO3–BaTiO3 (BF–BT)-based lead-free ceramics possess the ultrahigh Curie temperature Tc and relatively large piezoelectric constant d33, there is still a huge fluctuation of the real-time d33 in th...
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Article
Open AccessDNA-based molecular classifiers for the profiling of gene expression signatures
Although gene expression signatures offer tremendous potential in diseases diagnostic and prognostic, but massive gene expression signatures caused challenges for experimental detection and computational analy...
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Article
Human pangenome: far-reaching implications in precision medicine
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Article
Optimization method and experimental research on robot belt grinding trajectory of additive blade with non-uniform allowance distribution
When robotic belt grinding was used to machine aeroadditive blade that had non-uniform distribution of the allowance, the traditional trajectory planning method did not take into account of the complexity of e...
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Article
Open AccessRemnant cholesterol, iron status and diabetes mellitus: a dose–response relationship and mediation analysis
Remnant cholesterol (RC) is recognized as a risk factor for diabetes mellitus (DM). Although iron status has been shown to be associated with cholesterol metabolism and DM, the association between RC, iron sta...
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Article
Responses of growth, yield and fruit quality of strawberry to elevated CO2, LED supplemental light, and their combination in autumn through spring greenhouse production
During the whole growth cycle growth, yield and fruit quality of strawberry are often strongly affected by insufficient CO2 and low light in greenhouse production. However, it is still not clear what extent growt...
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Article
Open AccessRegulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis
Paraquat (PQ) is an irreplaceable insecticide in many countries for the advantage of fast-acting and broad-spectrum. However, PQ was classified as the most prevailing poisoning substance for suicide with no sp...
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Article
Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure
Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis failure. Mesothelial cell loss is an initiating event for peritoneal fibrosis. We find that the elevated gluc...
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Article
High-temperature dielectric polymer composite for high power energy storage applications
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Article
Eco-friendly and efficient synthesis of nitrogen-doped carbon quantum dots for pH sensing applications
Nitrogen-doped carbon quantum dots (N-doped CQDs) were prepared using a one-step sintering technique, with ammonium citrate as the precursor. These were compared to carbon quantum dots (CQDs) synthesized from ...
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Chapter and Conference Paper
On the Design of College Chinese Multimedia Teaching System
Chinese is a language that has been used for thousands of years. It is one of the most spoken languages in the world. Chinese is the official language of China, Taiwan, Singapore, Malaysia and many other count...
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Article
Open AccessA retrospective real-world study: the efficacy of immune-related combination therapies in advanced non-small cell lung cancer after resistance to EGFR-TKIs
Whether patients with advanced non-small cell lung cancer (NSCLC) should choose an immune-combination therapy regimen after EGFR-tyrosine kinase inhibitors (EGFR-TKIs) resistance is currently unclear.
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Article
Amyloid-β mediates intestinal dysfunction and enteric neurons loss in Alzheimer's disease transgenic mouse
Alzheimer's disease (AD) is traditionally considered as a brain disorder featured by amyloid-β (Aβ) deposition. The current study on whether pathological changes of AD extend to the enteric nervous system (ENS...
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Article
Open AccessAssociations between maternal occupational exposures and pregnancy outcomes among Chinese nurses: a nationwide study
Several studies have provided evidence about adverse pregnancy outcomes of nurses involved in occupational exposure. However, the pregnancy outcomes among nurses in middle-income countries are not well demonst...
