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Article
On the Probability of Generating a Primitive Matrix
Given a k × n integer primitive matrix A (i.e., a matrix can be extended to an n × n unimodular matrix over the integers) with the maximal absolute value of entries ∥A∥ bounded by an integer λ from above, the aut...
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Article
Open AccessMTF1 genetic variants are associated with lung cancer risk in the Chinese Han population
Metal-regulatory transcription factor 1 (MTF1), a conserved metal-binding transcription factor in eukaryotes, regulates the proliferation of cancer cells by activating downstream target genes and then particip...
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Article
Open AccessMXene-based all-solid flexible electrochromic microsupercapacitor
With the increasing demand for multifunctional optoelectronic devices, flexible electrochromic energy storage devices are being widely recognized as promising platforms for diverse applications. However, simul...
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Article
Open AccessRestoration of functional endometrium in an intrauterine adhesion rat model with endometrial stromal cells transplantation
Intrauterine adhesion (IUA) as a prevalent gynecological disease is developed from infection or trauma. However, therapeutic strategies to repair damaged endometrium are relatively limited. Emerging studies ha...
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Article
Open AccessIdentification of potential modulators for human GPD1 by docking-based virtual screening, molecular dynamics simulations, binding free energy calculations, and DeLA-drug analysis
Cytosolic Glycerol-3-phosphate dehydrogenase 1 (GPD1, EC 1.1.1.8) plays a pivotal role in regulating the Embden-Meyerhof glucose glycolysis pathway (E-M pathway), as well as in conditions such as Huntington’s ...
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Article
Open AccessRefined implicit characterization of engineering geology with uncertainties: a divide-and-conquer tactic-based approach
In engineering geology, a reasonable assessment of the spatial distribution of uncertainty in a region is vital in guiding research, saving money, and shortening the period. However, the traditional modeling p...
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Article
Open AccessSingle-cell and bulk RNA-seq unveils the immune infiltration landscape associated with cuproptosis in cerebral cavernous malformations
Cerebral cavernous malformations (CCMs) are vascular abnormalities associated with deregulated angiogenesis. Their pathogenesis and optimal treatment remain unclear. This study aims to investigate the molecula...
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Article
Differential testing solidity compiler through deep contract manipulation and mutation
Solidity, the language utilized for develo** smart contracts, has been gaining increased importance in blockchain system. Ensuring bug-free of its accompanying language compiler, which converts the contract ...
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Article
Surface air temperature change in the Wuyi Mountains, southeast China
Detecting changes in surface air temperature in mid- and low-altitude mountainous regions is essential for a comprehensive understanding of warming trend with altitude. We use daily surface air temperature dat...
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Article
Sustainable regeneration of spent cathodes for lithium-ion and post-lithium-ion batteries
The accelerating adoption of electric vehicles supports the transition to a more sustainable transport sector. However, the retiring of many electric vehicles over the next decade poses a sustainability challe...
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Article
Comparative Transcriptomic Analysis of Different Potato Cultivars to Elucidate the Molecular Mechanisms Underlying Differences in Cold Resistance
Amongst the various abiotic stresses, cold is an essential factor that limits crop productivity worldwide. Low temperature affects the growth, development, and distribution of agronomic species around the worl...
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Article
Open AccessHighly diverse sputum microbiota correlates with the disease severity in patients with community-acquired pneumonia: a longitudinal cohort study
Community-acquired pneumonia (CAP) is a common and serious condition that can be caused by a variety of pathogens. However, much remains unknown about how these pathogens interact with the lower respiratory co...
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Article
Open AccessUHPLC-HRMS-based Multiomics to Explore the Potential Mechanisms and Biomarkers for Colorectal Cancer
Understanding the metabolic changes in colorectal cancer (CRC) and exploring potential diagnostic biomarkers is crucial for elucidating its pathogenesis and reducing mortality. Cancer cells are typically deriv...
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Article
Open AccessA cohort study of self-perception of ageing and all-cause mortality among older adults in China: a multiple mediators analysis
Positive self-perception of aging (SPA) is a well-known predictor of longevity, while how and to what extent SPA is linked with all-cause mortality among older adults is still unclear. This study aims to eluci...
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Article
Open AccessGenerative design of compounds with desired potency from target protein sequences using a multimodal biochemical language model
Deep learning models adapted from natural language processing offer new opportunities for the prediction of active compounds via machine translation of sequential molecular data representations. For example, c...
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Article
Open AccessAberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study
Prior neuroimaging studies on vestibular migraine (VM) have extensively certified the functional and structural alterations in multiple brain regions and networks. However, few studies have assessed the cerebr...
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Article
DSTC-Net: differential spatio-temporal correlation network for similar action recognition
Skeleton-based action recognition methods have made impressive progress. But to enhance the discrimination of similar actions, it needs to focus on learning the difference information in spatio-temporal featur...
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Article
Open AccessEffect of baicalin on eradicating biofilms of bovine milk derived Acinetobacter lwoffii
Acinetobacter lwoffii (A.lwoffii) is a serious zoonotic pathogen that has been identified as a cause of infections such as meningitis, bacteremia and pneumonia. In recent years, the infection rate and detection r...
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Article
Open AccessmPPTMP195 nanoparticles enhance fracture recovery through HDAC4 nuclear translocation inhibition
Delayed repair of fractures seriously impacts patients’ health and significantly increases financial burdens. Consequently, there is a growing clinical demand for effective fracture treatment. While current ma...
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Article
Open AccessUsing optical coherence tomography to assess luster of pearls: technique suitability and insights
Luster is one of the vital indexes in pearl grading. To find a fast, nondestructive, and low-cost grading method, optical coherence tomography (OCT) is introduced to predict the luster grade through the textur...
