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Article
Open AccessIntegrated machine learning algorithms reveal a bone metastasis-related signature of circulating tumor cells in prostate cancer
Bone metastasis is an essential factor affecting the prognosis of prostate cancer (PCa), and circulating tumor cells (CTCs) are closely related to distant tumor metastasis. Here, the protein-protein interactio...
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Article
A non-invasive artificial intelligence model for identifying axillary pathological complete response to neoadjuvant chemotherapy in breast cancer: a secondary analysis to multicenter clinical trial
This study aims to develop a stacking model for accurately predicting axillary lymph node (ALN) response to neoadjuvant chemotherapy (NAC) using longitudinal MRI in breast cancer.
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Article
A recursive construction of doubly resolvable Steiner quadruple systems
Two resolutions of the same 3-design are said to be orthogonal when each parallel class of one resolution has at most one block in common with each parallel class of the other resolution. If a Steiner quadrupl...
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Article
Open AccessSimultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor choice
The simultaneous measurement of three-dimensional (3D) genome structure and gene expression of individual cells is critical for understanding a genome’s structure–function relationship, yet this is challenging...
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Article
Role of miRNAs in macrophage-mediated kidney injury
Macrophages, crucial components of the human immune system, can be polarized into M1/M2 phenotypes, each with distinct functions and roles. Macrophage polarization has been reported to be significantly involve...
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Article
Open AccessDDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding
Hyaline cartilage fibrosis is typically considered an end-stage pathology of osteoarthritis (OA), which results in changes to the extracellular matrix. However, the mechanism behind this is largely unclear. He...
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Article
Open AccessAuthor Correction: scCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells
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Article
Analysis of the Cadmium Removal Mechanism of Human Gut Bacteria Enterococcus faecalis Strain ATCC19433 from a Genomic Perspective
Cadmium (Cd) is one of the most well-known toxic metals capable of entering the human body via the food chain, leading to serious health problems. Human gut microbes play a pivotal role in controlling Cd bioav...
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Article
Synthesis of multicolor fluorescent CDs from natural plant kaempferide and their application in anti-counterfeiting inks
Carbon dots (CDs) are versatile nanomaterials with tunable luminescent properties. We used a natural plant kaempferol as a carbon source to synthesize multicolor CDs by reacting it with various nitrogen source...
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Article
Open AccessExpression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease
IgG4-related disease (IgG4-RD) has complex clinical manifestations ranging from fibrosis and inflammation to deregulated metabolism. The molecular mechanisms underpinning these phenotypes are unclear. In this ...
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Article
One-pot Synthesis of High-performance Green-emitting Carbon Dots for Cd2+ Sensing and Anti-counterfeiting Applications
This study presents a facile one-pot solvothermal synthesis of high-performance green fluorescent carbon dots (G-CDs) using o-phenylenediamine and ethylenediamine as precursors. The G-CDs show excellent optica...
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Article
Open AccessCanopy gap impacts on soil organic carbon and nutrient dynamic: a meta-analysis
The forest canopy gaps, formed by natural or anthropogenic factors, have been found to reduce soil carbon content and increase nutrient availability. The magnitudes of these effects have been observed to incre...
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Article
Open AccessscCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells
Extrachromosomal circular DNAs (eccDNAs) have emerged as important intra-cellular mobile genetic elements that affect gene copy number and exert in trans regulatory roles within the cell nucleus. Here, we desc...
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Article
Open AccessConstruction and evaluation of immune-related diagnostic model in patients with heart failure caused by idiopathic dilated cardiomyopathy
The purpose of the study was to construct the potential diagnostic model of immune-related genes during the development of heart failure caused by idiopathic dilated cardiomyopathy.
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Article
Risk and effect modifiers for poor glycemic control among the chinese diabetic adults on statin therapy: the kailuan study
Limited studies have investigated the association between statin therapy and poor glycemic control, especially in the Chinese diabetic population.
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Article
Open AccessFibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1
Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, the detailed mechanism by which fibroblasts, which are the main components of fibrous sc...
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Chapter and Conference Paper
Analysis of Non-intellectual Factors Affecting K-12 Student Academic Performance Using the Random Forest Model
Objective: A random forest algorithm was used to analyze non-intellectual factors that directly affect student achievement at the K-12 level and provide targeted strategies for addressing these factors. Method...
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Article
Open AccessCorrelation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis
Growing evidence has demonstrated that patients undergoing peritoneal dialysis (PD) are more likely to experience cognitive impairment than patients with non-dialysis end-stage renal disease (ESRD); however, t...
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Article
Effects of Different Conditioners on Humus Composition and Humic Acid Structural Characteristics in Black Soil Under the Combined Application of Pig Manure and Straw
The objective of this study was to assess the changes in the composition and structure of humic acid (HA) following the application of different conditioners in combination with manure and straw. The experimen...
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Article
Short-term changes in soil labile carbon and nitrogen pools with biochar application in a suburban native forest in subtropical Australia
Soil labile carbon (C) and nitrogen (N) pools are vital indicators of soil fertility and soil organic matter (SOM) dynamics. We aimed to evaluate the short-term effects of biochar application on soil labile C ...
