24 Result(s)
within
**gqi Chen
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessInfluence of thickness and strength on plastic instability in tailored steel structures
A mathematical model was intricately devised to explore the influence of continuous variations in thickness and mechanical properties on the performance of tailor rolled blanks (TRB) and tailor rolled tubes (T...
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Article
Open AccessEvaluation of agricultural non-point source pollution using an in-situ and automated photochemical flow analysis system
Off-line leachate collection from agricultural landscapes cannot guarantee precise evaluation of agricultural non-point source (ANPS) due to geospatial variations, time, and transportation from the field to th...
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Article
Open AccessEmpowering high-dimensional optical fiber communications with integrated photonic processors
Mode-division multiplexing (MDM) in optical fibers enables multichannel capabilities for various applications, including data transmission, quantum networks, imaging, and sensing. However, high-dimensional opt...
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Article
Open AccessAn injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment
Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the deve...
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Article
Open AccessTadA orthologs enable both cytosine and adenine editing of base editors
Cytidine and adenosine deaminases are required for cytosine and adenine editing of base editors respectively, and no single deaminase could enable concurrent and comparable cytosine and adenine editing. Additi...
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Article
Open AccessTadA reprogramming to generate potent miniature base editors with high precision
Although miniature CRISPR-Cas12f systems were recently developed, the editing efficacy and targeting range of derived miniature cytosine and adenine base editors (miniCBEs and miniABEs) have not been comprehen...
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Article
Open AccessCell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
There is ample support for developmental regulation of glioblastoma stem cells. To examine how cell lineage controls glioblastoma stem cell function, we present a cross-species epigenome analysis of mouse and ...
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Open AccessDome-arrayed chitosan/PVA hydrogel-based solar evaporator for steam generation
Water evaporation systems with solar energy as the primary driving energy have received extensive attention in recent years. This work studies the preparation method and performance of hydrogel evaporators usi...
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Open AccessGeneral synthesis of ultrafine metal oxide/reduced graphene oxide nanocomposites for ultrahigh-flux nanofiltration membrane
Graphene-based membranes have great potential to revolutionize nanofiltration technology, but achieving high solute rejections at high water flux remains extremely challenging. Herein, a family of ultrafine me...
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Open AccessA H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging
Develo** high-quality NIR-II fluorophores (emission in 1000–1700 nm) for in vivo imaging is of great significance. Benzothiadiazole-core fluorophores are an important class of NIR-II dyes, yet ongoing limita...
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Article
Open AccessFocal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, we identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, a...
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Open AccessThe short-term associations of chronic obstructive pulmonary disease hospitalizations with meteorological factors and air pollutants in Southwest China: a time-series study
Chronic obstructive pulmonary disease (COPD) is the fourth major cause of mortality and morbidity worldwide and is projected to be the third by 2030. However, there is little evidence available on the associat...
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Article
Open AccessHarvesting energy from sun, outer space, and soil
While solar power systems have offered a wide variety of electricity generation approaches including photovoltaics, solar thermal power systems, and solar thermoelectric generators, the ability to generate ele...
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Article
Open AccessBlackbody-cavity ideal absorbers for solar energy harvesting
Spectrally selective solar absorbers (SSAs), which harvest heat from sunlight, are the key to concentrated solar thermal systems. An ideal SSA must have an absorptivity of unity in the solar irradiance wavelen...
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Article
Open AccessDocking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination
Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editor...
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Article
Open AccessYeast homologs of human MCUR1 regulate mitochondrial proline metabolism
Mitochondria house evolutionarily conserved pathways of carbon and nitrogen metabolism that drive cellular energy production. Mitochondrial bioenergetics is regulated by calcium uptake through the mitochondria...
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Article
Open AccessGenome-wide analysis of fatty acid desaturase genes in rice (Oryza sativa L.)
Fatty acid desaturases can catalyze saturated or unsaturated fatty acids to form a double bond at various locations in the hydrocarbon chain. In the present study, a total of 20 full-length desaturase genes we...
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Open AccessComprehensive analysis of landslide stability and related countermeasures: a case study of the Lanmuxi landslide in China
We report on a comprehensive method for analyzing landslide stability and the mitigation effect of countermeasures in this paper. The proposed method is a combination of theoretical method and numerical method...
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Article
Open AccessDetection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome
Immune responses play an important role in the pathogenesis of polycystic ovary syndrome (PCOS). However, the characteristics of T lymphocyte subsets in PCOS remain insufficiently understood. In this study, ly...
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Open AccessJoint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity
Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In conjunction with DNA transposition, the lev...
