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Article
Population pharmacokinetics of cyclosporine A in pediatric patients with thalassemia undergoing allogeneic hematopoietic stem cell transplantation
To establish the population pharmacokinetics (PPK) model of cyclosporine A(CsA) in pediatric patients with thalassemia undergoing allogeneic hematopoietic stem cell transplantation (HSCT), aiming at providing ...
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Article
Stability Deterioration Analysis of Toppling Dangerous Rock Mass under the Combined Effect of Vibration and Freeze-Thaw Cycles
To investigate the degree of stability deterioration in toppling dangerous rock mass under different action times, firstly, the vibration load generated by train travel in a single action and its decay law wer...
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Article
Effect of different water contents on the softening characteristics of clay under intermittent cyclic dynamic loading
Dynamic triaxial tests were conducted to investigate the occurrence of intermittent periods and the effect of different moisture contents on the cumulative plastic strain and softening characteristics of clay ...
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Article
Open AccessSPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination
A sphingolipid metabolite regulator, sphingosine kinase 1 (SPHK1), plays a critical role in the development of colorectal cancer (CRC). Studies have demonstrated that invasion and metastasis of CRC are promote...
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Article
Open AccessCorrection: Long-term follow-up after discharge witnesses a slow decline of insulin autoantibodies in patients with insulin autoimmune syndrome complicated with grave’s disease: a report of two cases
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Article
Open AccessImported and indigenous Plasmodium Vivax and Plasmodium Falciparum malaria in the Hubei Province of China, 2005–2019
The Hubei Province in China reported its last indigenous malaria case in September 2012, but imported malaria cases, particularly those related to Plasmodium vivax and Plasmodium falciparum, threaten Hubei’s mala...
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Article
Open AccessNanopore long-read RNA sequencing reveals functional alternative splicing variants in human vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and remodeling, which showed high level of phenotypic plasticity. Abnormalities in VSMC plasticity can lead to multiple cardiov...
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Article
Advances in studies of circulating microRNAs: origination, transportation, and distal target regulation
In the past few years, numerous advances emerged in terms of circulating microRNA(miRNA) regulating gene expression by circulating blood to the distal tissues and cells. This article reviewed and summarized th...
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Article
AUF1-induced circular RNA hsa_circ_0010467 promotes platinum resistance of ovarian cancer through miR-637/LIF/STAT3 axis
Increasing evidences has indicated that primary and acquired resistance of ovarian cancer (OC) to platinum is mediated by multiple molecular and cellular factors. Understanding these mechanisms could promote t...
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Article
Open AccessLong-term follow-up after discharge witnesses a slow decline of insulin autoantibodies in patients with insulin autoimmune syndrome complicated with Grave’s disease: a report of two cases
Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia characterized by high levels of blood insulin autoantibodies. It has been documented that drugs containing sulfhydryl groups may result in IAS....
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Article
Open AccessSystematic characterization of cancer transcriptome at transcript resolution
Transcribed RNAs undergo various regulation and modification to become functional transcripts. Notably, cancer transcriptome has not been fully characterized at transcript resolution. Herein, we carry out a re...
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Article
Open AccessCommunity-based heat-sensitive moxibustion for primary hypertension: study protocol for a randomized controlled trial with patient-preference arms
Low- and middle-income countries have a high prevalence of primary hypertension, but its treatment and control are often low. Heat-sensitive moxibustion (HSM), an innovative acupoint stimulation technique, may...
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Article
Author Correction: Multidimensional gene regulatory landscape of a bacterial pathogen in plants
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCharacteristics of imported Plasmodium ovale spp. and Plasmodium malariae in Hubei Province, China, 2014–2018
There have been an increasing number of imported cases of malaria in Hubei Province in recent years. In particular, the number of cases of Plasmodium ovale spp. and Plasmodium malariae significantly increased, wh...
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Article
Multidimensional gene regulatory landscape of a bacterial pathogen in plants
Understanding the gene regulation of plant pathogens is crucial for pest control and thus global food security. An integrated understanding of bacterial gene regulation in the host is dependent on multi-omic d...
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Article
A modified transient gene expression protocol for subcellular protein localization analysis in rice
Transient protein expression is a useful technique for investigating the protein localization and functional analysis of stress responses in rice plants. Currently, available methods for in planta transient ex...
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Article
Open AccessSite-specific cleavage of bacterial MucD by secreted proteases mediates antibacterial resistance in Arabidopsis
Plant innate immunity restricts growth of bacterial pathogens that threaten global food security. However, the mechanisms by which plant immunity suppresses bacterial growth remain enigmatic. Here we show that Ar...
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Article
Active tuberculosis in patients with systemic lupus erythematosus from Southern China: a retrospective study
To investigate the characteristics and associated factors for Mycobacterium tuberculosis (TB) infection in patients with systemic lupus erythematosus (SLE) from Southern China. A retrospective study of 1108 patie...
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Article
Ferroelectric, dielectric, ferromagnetic and magnetoelectric properties of the multiferroic heteroepitaxial NiFe2O4/Ba0.85Ca0.15Ti0.9Zr0.1O3 composite thin films deposited via PLD
Heterostructured NiFe2O4/Ba0.85Ca0.15Ti0.9Zr0.1O3 (NFO/BCZT) composite thin films grown epitaxially on (100)-SrRuO3/SrTiO3 substrate (SrRuO3 is used as the bottom electrode) were prepared via pulse laser depositi...
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Article
Cr3+ activated Zn3Al2Ge3O12: a novel near-infrared long persistent phosphor
The near-infrared (NIR) long persistent phosphors have gained considerable attention owing to the potential applications in in vivo imaging. A novel NIR long-persistent phosphors Zn3Al2Ge3O12:Cr3+ was successfull...
