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Article
Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study
Selenium (Se) is an essential trace element for maintaining human health, for example, plays a crucial role in preventing aging-related diseases. However, most studies on the health effects of Se among the com...
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Article
Effects of Reinforcement Content and Homogenization Treatment on the Microstructure and Mechanical Properties of in-situ TiB2/2219Al Composites
Obtaining an appropriate grain size is crucial for Al alloys or Al matrix composites prior to processing, as it significantly influences the mechanical properties of components and workability during the manuf...
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Article
Open AccessPenpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study
Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity, and thus theoretically reduced immune-related adverse events (irAEs) while maintaining effi...
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Article
Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models
CRPC remains a significant challenge in prostate cancer research. We aimed to elucidate the role of gut microbiota and its specific mechanisms in CRPC using a multidisciplinary approach. We analyzed 16S rRNA s...
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Article
Open AccessScreening of co-expressed genes in hypopharyngeal carcinoma with esophageal carcinoma based on RNA sequencing and Clinical Research
To explore the hub comorbidity genes and potential pathogenic mechanisms of hypopharyngeal carcinoma with esophageal carcinoma, and evaluate their diagnostic value for hypopharyngeal carcinoma with co-morbid e...
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Article
Open AccessQualitative and quantitative MRI analysis of alveolar soft part sarcoma: correlation with histological grade and Ki-67 expression
To investigate the correlation between MRI findings and histological features for preoperative prediction of histological grading and Ki-67 expression level in alveolar soft part sarcoma (ASPS).
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Article
Effect of Dip** Time on Microstructure and Properties of Zn-1Al-2Mg Coating by Hot-Dip** Galvanizing
The purpose of this study is to investigate the effect of dip** time (30, 60, 90, 120, 150 s) on the microstructure and corrosion resistance of Zn-1Al-2Mg coating under ammonium-free flux. The coatings were ...
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Article
Open AccessRadiomics of pericoronary adipose tissue on computed tomography angiography predicts coronary heart disease in patients with type 2 diabetes mellitus
Diabetes is a common chronic metabolic disease. The progression of the disease promotes vascular inflammation and the formation of atherosclerosis, leading to cardiovascular disease. The coronary artery periva...
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Article
Study of electronic biofeedback combined with nursing intervention in the treatment of vascular cognitive impairment-no dementia
To investigate the effects of electronic biofeedback combined with nursing intervention and conventional drug treatment on cognitive function in patients with vascular cognitive impairment-no dementia (VCIND).
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Article
CircRNA_0088196 Regulates Trophoblast Proliferation and Apoptosis in Preeclampsia Through the miR-379-5p/HSPA5 Axis
Existing research has confirmed the dysregulation of circular RNA (circRNA) in a wide variety of human diseases. Thus, in this study, we explored the potential mechanism of circRNA_0088196 in preeclampsia (PE)...
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Article
The endoplasmic reticulum stress protein GRP94 modulates cathepsin L activity in M2 macrophages in conditions of obesity-associated inflammation and contributes to their pro-inflammatory profile
Adipose tissue macrophages (ATM) are key actors in the pathophysiology of obesity-related diseases. They have a unique intermediate M2-M1 phenotype which has been linked to endoplasmic reticulum (ER) stress. W...
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Article
Dual-drug-loaded MSCs-derived exosomal vesicles inhibit endometrial cancer cell proliferation by promoting apoptosis through the migration and invasion of Rac1/NF-κB/MMP2 signalling pathway
Endometrial carcinoma affects the uterine lining. Endogenous activity, intrinsic targeting, and ability to engage with a host defence system make exosomal vehicles (EVs) a viable cancer treatment alternative. ...
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Article
Open AccessMolecular-strain induced phosphinidene reactivity of a phosphanorcaradiene
Phosphanorcaradienes are an appealing class of phosphorus compounds that can serve as synthons of transient phosphinidenes. However, the synthesis of such species is a formidable task owing to their intrinsic ...
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Article
Joint multi-server cache sharing and delay-aware task scheduling for edge-cloud collaborative computing in intelligent manufacturing
The rapid advancement of intelligent manufacturing has led to an increasing demand for computing resources in industrial computing tasks. As a new computing paradigm, edge-cloud collaborative computing (E3C) f...
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Article
Microstructure Evolution and Mechanical Properties at Ambient and Elevated Temperatures of in-situ TiB2/2219Al Matrix Composites During Cold Rolling
Cold rolling is one of the feasible and effective methods for regulating the microstructure and enhancing the mechanical properties of metallic materials. However, the cold rolling of particulate-reinforced al...
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Article
Open AccessPublisher Correction: Unlocking Li superionic conductivity in face-centred cubic oxides via face-sharing configurations
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Article
A Novel Method for Human-Vehicle Recognition Based on Wireless Sensing and Deep Learning Technologies
Currently, human-vehicle recognition (HVR) method has been applied in road monitoring, congestion control, and safety protection situations. However, traditional vision-based HVR methods suffer from problems s...
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Article
Open AccessIce sheet and precession controlled subarctic Pacific productivity and upwelling over the last 550,000 years
The polar oceans play a vital role in regulating atmospheric CO2 concentrations (pCO2) during the Pleistocene glacial cycles. However, despite being the largest modern reservoir of respired carbon, the impact of ...
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Article
Open AccessGenomic characterization and related functional genes of γ- poly glutamic acid producing Bacillus subtilis
γ- poly glutamic acid (γ-PGA), a high molecular weight polymer, is synthesized by microorganisms and secreted into the extracellular space. Due to its excellent performance, γ-PGA has been widely used in vario...
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Article
Hydrangea-like TiO2/Bi2MoO6 porous nanoflowers triggering highly sensitive electrochemical immunosensing to tumor marker
Rapid and sensitive detection of carcinoembryonic antigen (CEA) is of great significance for cancer patients. Here, molybdenum (Mo) was doped into bismuth oxide (Bi2O3) by one-pot hydrothermal method forming poro...
