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Article
Enhanced Thermal Hydrolysis of Sewage Sludge by Introducing Tannic Acid (TA)
Thermal hydrolysis is becoming a crucial approach to enhance the level of sewage sludge resource utilization. Introducing additives became the dominant way to improve thermal hydrolysis efficiency for sewage s...
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Article
Human umbilical cord mesenchymal stem cells attenuate diabetic nephropathy through the IGF1R-CHK2-p53 signalling axis in male rats with type 2 diabetes mellitus
Diabetes mellitus (DM) is a disease syndrome characterized by chronic hyperglycaemia. A long-term high-glucose environment leads to reactive oxygen species (ROS) production and nuclear DNA damage. Human umbili...
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Article
Open AccessBOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer
The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) and exemestane (EXE) in the treatment of estrogen receptor positive (ER +), HER2-, advanced breast cancer (ABC). BO...
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Article
Open AccessInhibition and transport mechanisms of the ABC transporter hMRP5
Human multidrug resistance protein 5 (hMRP5) effluxes anticancer and antivirus drugs, driving multidrug resistance. To uncover the mechanism of hMRP5, we determine six distinct cryo-EM structures, revealing an...
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Article
Online Multi-Object Tracking Under Moving Unmanned Aerial Vehicle Platform Based on Object Detection and Feature Extraction Network
In order to solve the problem of small object size and low detection accuracy under the unmanned aerial vehicle (UAV) platform, the object detection algorithm based on deep aggregation network and high-resolut...
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Article
Open AccessMetformin is a potential therapeutic for COVID-19/LUAD by regulating glucose metabolism
Lung adenocarcinoma (LUAD) is the most common and aggressive subtype of lung cancer, and coronavirus disease 2019 (COVID-19) has become a serious public health threat worldwide. Patients with LUAD and COVID-19...
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Article
Computational study on the binding mechanism of allosteric drug TNO155 inhibiting SHP2E76A
E76A mutations of SHP2 have been reported to associate with genetic developmental diseases and cancers, and TNO155 is one of the effective inhibitors targeted to the allosteric site 1, which has already entered t...
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Article
Broadband angular spectrum analog processors based on all-dielectric metasurfaces
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Article
Highly Selective CO2 Separation on Na-exchanged DNL-6 Synthesized by Utilization of Spent Industrial Catalyst
Conversion of industrial solid wastes into functional materials has attracted considerable interest, as it can reduce environmental pollution and facilitate the sustainable development of relevant processes. H...
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Article
Open AccessNonlinear relationship between oxidative balance score and hyperuricemia: analyses of NHANES 2007–2018
Limited data regarding the correlation between oxidative balance score (OBS) and hyperuricemia highlights the necessity for thorough investigations. This study aims to examine the link between OBS, which incor...
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Article
Open AccessSafety and efficacy of umbilical cord tissue-derived mesenchymal stem cells in the treatment of patients with aging frailty: a phase I/II randomized, double-blind, placebo-controlled study
Mesenchymal stem cells (MSCs) hold a great promise for cell-based therapy in the field of regenerative medicine. In this study, we aimed to evaluate the safety and efficacy of intravenous infusion of human umb...
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Article
Open AccessThermal decomposition characteristics of BHT and its peroxide (BHTOOH)
2,6-Di-tert-butyl-4-methylphenol (BHT) is an excellent antioxidant that is easily oxidized to 2,6-di-tert-butyl-4-hydroperoxyl-4-methyl-2,5-cyclohexadienone (BHTOOH). For the safety of BHT production and usage...
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Article
Open AccessStructural characteristics of alpha-fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites
Alpha-fetoprotein (AFP), a serum glycoprotein, is expressed during embryonic development and the pathogenesis of liver cancer. It serves as a clinical tumor marker, function as a carcinogen, immune suppressor,...
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Article
A hybrid spatial-temporal deep learning prediction model of industrial methanol-to-olefins process
Methanol-to-olefins, as a promising non-oil pathway for the synthesis of light olefins, has been successfully industrialized. The accurate prediction of process variables can yield significant benefits for adv...
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Article
Open AccessTranslation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis
Protein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is poorly understood. Here, we...
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Article
Multi-parameter Gold-Film Embedded PCF Sensors Based on Surface Plasmon Resonance
A novel multi-purpose sensor based on photonic crystal fiber and surface plasmon resonance is proposed, in which a gold film is deposited on the outer surface of the photonic crystal fiber to stimulate the sur...
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Article
Enhancing anti-tumor therapy with agmatine-cholesterol conjugate liposomes: in vitro and in vivo evidence
In this study, we synthesized a novel compound, agmatine-cholesterol conjugate (AG-Chol), to enhance the anti-tumor activity of drug-loaded liposomes. We replaced cholesterol with AG-Chol in preparing doxorubi...
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Article
ASO Author Reflections: Clinical Value of Navigation Systems for RAPN and LPN Procedures
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Article
Breakdown of effective medium theory: A study of photonic spin Hall effect in deep-subwavelength all-dielectric multilayers
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Article
Quantifying the Infiltration Capacity of High-Turbidity Rivers Under the Conditions of Fine Particle Clogging and Resuspension
Clogging and resuspension of fine particles in high-turbidity rivers affect riverbed infiltration capacity and limit aquifer recharge. This study simulated these two processes on riverbeds with different parti...
