-
Article
Asymptotic behavior of traveling wavefronts for nonlinear reaction–diffusion equations with relativistic-type diffusions
This paper is concerned with the nonlinear reaction–diffusion equations with relativistic-type diffusions. The proposed approach utilized to establish the new results of existence and asymptotic behavior of tr...
-
Article
Microstructure and Properties of the LDEDed Cu-Bearing Martensitic Stainless Steel After a Single-Step Tempering Treatment
431 martensitic stainless steels (MSS) alloying with copper (Cu, 0–3.5 wt%) have been fabricated by a laser directed energy deposition technology and treated by a single-step tempering treatment. The microstru...
-
Article
Open AccessDevelopment of a nomogram for prediction of central lymph node metastasis of papillary thyroid microcarcinoma
Papillary thyroid carcinoma (PTC) is the most frequent malignant tumor in thyroid carcinoma. The aim of this study was to explore the risk factors associated with central lymph node metastasis in papillary thy...
-
Article
Effects of Scanning Strategies on the Distortion and Properties of Laser-Repaired Thin-Plate 2Cr13 Steel
In order to explore the effects of scanning strategies on the distortion and properties of laser-repaired thin-plate components, four commonly used strategies, including continuous raster scanning strategy, co...
-
Article
Burden and trends of mental disorders in China from 1990 to 2019: findings from the Global Burden of Disease Study 2019
Mental disorders remain the leading causes of disability worldwide. We aimed to determine the burden and trends of mental disorders in China from 1990 to 2019.
-
Article
Open AccessEffect of High-Fat Food on the Pharmacokinetic Profile and Safety of SAF-189s, an ALK/ROS1 Inhibitor, in Healthy Chinese Adults
This study was conducted to investigate the effect of high-fat meals on the pharmacokinetics (PK) and safety profile of SAF-189s, a novel ALK/ROS1 inhibitor.
-
Article
Open AccessIdentification of an exosome-related signature associated with prognosis and immune infiltration in breast cancer
Exosomes, nanosized vesicles, play a vital role in breast cancer (BC) occurrence, development, and drug resistance. Hence, we proceeded to study the potential prognostic value of exosome-related genes and thei...
-
Article
Open AccessLactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer
Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying the initiation, propagation, and ultimate execution of...
-
Article
Open AccessDetection of Cd2+ based on Nano-Fe3O4/MoS2/Nafion/GCE sensor
It is necessary to detect cadmium ions in seawater with high sensitivity because the pollution of cadmium ions seriously endangers the health and life of human beings. Nano-Fe3O4/MoS2/Nafion modified glassy carbo...
-
Article
Open AccessExosomal ACADM sensitizes gemcitabine-resistance through modulating fatty acid metabolism and ferroptosis in pancreatic cancer
This study aimed to evaluate the potential of exosomes from cancer cells to predict chemoresistance in pancreatic cancer (PC) and explore the molecular mechanisms through RNA-sequencing and mass spectrometry. ...
-
Article
Adaptation mechanisms of the soil microbial community under stoichiometric imbalances and nutrient-limiting conditions in a subtropical nitrogen-saturated forest
Anthropogenic activities have increased the nitrogen (N) inputs in terrestrial ecosystems, thereby altering both the carbon (C) and phosphorus (P) availability along with resource stoichiometry. Stoichiometric...
-
Article
The catalytic mechanism and limiting factor of polyamide hydrolysis for chemical recycling: the classic hydrolysis of polyamide 4
A series of chemical recycling methods have been developed for polyamides (PAs) for green and sustainable technologies of plastic waste. However, the study of the essential mechanism of advanced thermo-chemica...
-
Article
The gravitational potential and its first- and second-order partial derivatives of an ellipsoidal tesseroid based on the Cartesian integral kernel
Gravity forward modelling is a fundamental problem in the fields of geophysics and geodesy at regional and global scales. Considering the curvature of the Earth, tesseroids are suitable to accurately simulate ...
-
Article
Effect of Food (Low and High Fat) on Pharmacokinetics of FCN-159, a Selective MEK Inhibitor, in Healthy Chinese Males
FCN-159 is a novel, oral, potent, selective MEK1/2 inhibitor in clinical development for the treatment of NRAS-mutant advanced melanoma and neurofibromatosis type 1. We investigated the effect of food on the phar...
-
Article
Open AccessAn exosome-related long non-coding RNAs risk model could predict survival outcomes in patients with breast cancer
Breast cancer (BC) is one of the most frequent malignancies among women worldwide. Accumulating evidence indicates that long non-coding RNA (lncRNA) may affect BC progression. Exosomes, a class of small membra...
-
Article
Powdery Food Identification Using NIR Spectroscopy and Extensible Deep Learning Model
Spectroscopy coupled with deep learning is widely studied for powdered food materials authentication, such as quality ranking and powder identification. However, the models need retraining when new categories ...
-
Article
Immune Persistence and Safety After SARS-CoV-2 BNT162b1 mRNA Vaccination in Chinese Adults: A Randomized, Placebo-Controlled, Double-Blind Phase 1 Trial
BNT162b1 is a lipid nanoparticle-formulated, nucleoside-modified mRNA SARS-CoV-2 vaccine. Here, we report safety and immune persistence data following a primary two-dose vaccination schedule administered 21 da...
-
Article
Sidewall shape control using direct laser fabrication technology
The sidewall collapse of laser forming parts severely affects the forming quality of these parts. In this study, a strategy for the shape control of sidewalls using direct laser fabrication technology was syst...
-
Article
Open AccessEpiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signaling
Chemoresistance often causes the failure of treatment and death of patients with advanced non-small-cell lung cancer. However, there is still no resistance genes signature and available enriched signaling deri...
-
Article
Globally Exponential Stability of Piecewise Pseudo Almost Periodic Solutions for Neutral Differential Equations with Impulses and Delays
In this paper, a kind of delayed impulsive neutral differential equations (DINDEs) has been studied. By making the use of contraction map** principle and generalized Gronwall-Bellmain inequality, some novel ...
